Clinical trials: Fluid Challenge
Surgery
Fluid Challenges and Microcirculation
The goal of this prospective observational study is to assess the impact of fluid challenge administration on macro and microcirculation in patients situated in the gray zone during a high risk abdominal surgery
- Trial name
- FC (NCT04559178)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Erasme University Hospital
Hypovolemia
Correlation Between ΔPP/HR and ΔSV During Fluid Challenge.
In high perioperative risk patients, guidelines suggest intraoperative haemodynamic optimization by measurement of stroke volume (SV) to guide fluid resucitation.This strategy requires an invasive monitoring and learning.
- Trial name
- ΔPP/HRvsΔSV (NCT02439242)
- Testing
- fluid challenge of saline
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Sepsis
Minimal Volume for a Fluid Challenge in Septic Patients
The administration of fluids intravenously is the first step in the stabilization of patients in septic shock. It is important to give the right dose of fluids, enough to improve the function of the cardiovascular system but not…
- Trial name
- NCT02447042
- Testing
- Fluid challenge with crystalloids, Measurement of Pmsf-arm
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- St George's, University of London
Septic Shock
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume induced by a rapid fluid…
- Trial name
- AUSTRALIS (NCT04693923)
- Testing
- Fluid challenge
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Fluid Challenge, Oxygen Consumption
Comparison of 250 ml Versus 500 ml of Fluid Challenge
The objective of fluid challenge is to increase oxygen delivery (DO2) in order to improve/restore tissue oxygen consumption (VO2).
- Conditions
- Fluid Challenge, Oxygen Consumption, Critical Care
- Trial name
- KOBIAS (NCT03874923)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pre-Eclampsia, Volume Overload
PREDICTION OF FLUID RESPONSIVENESS WITH PASSIVE LEG RISING IN PREGNANT PATIENTS WITH SEVERE PREECLAMPSIA
BACKGROUND: A cornerstone of treatment in preeclampsia is to correct the potential hypovolemia with intravascular optimisation, which is usually performed as a fluid challenge.
- Conditions
- Pre-Eclampsia, Volume Overload, Hemodynamic Instability
- Trial name
- NCT03755843
- Testing
- PASSIVE LEG RISING
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- RAUL CARRILLO ESPER
Migraine, Headache
Intravenous Fluid for Pediatric Migraine in the Emergency Department
The purpose of this study is to evaluate the effect of intravenous fluid (0.9% sodium chloride and water) alone on headache pain in children with migraine visiting the Emergency Department.
- Trial name
- EDMigraine3 (NCT01073787)
- Testing
- Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Alberta
Anesthesia, Spine Fusion
Fluid Responsiveness in Prone Position
We are planning to measure hemodynamic parameters (Heart Rate, Mean Arterial Pressure, Stroke Volume Index, Stroke Volume Variation, and Pulse Pressure Variation) and ventilatory parameters at four times (T1, T2,T3, and T4)…
- Trial name
- NCT05401526
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Fluid Therapy
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department
Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml , can predict fluid responsiveness in…
- Trial name
- MIBORED (NCT05369559)
- Testing
- Mini bolus 50, passive leg rising test
- Where
- 2 sites in Tunisia
- Volunteers
- 1,000 people
- Sponsor
- University of Monastir
Fluid Challenge, Increased Intracranial Pressure
Effect of Fluid Challenge on Intracranial Pressure
Fluid challenge is frequently used in fluid management of critically ill patients. Assessing whether there is a preload reserve that can be used to increase the stroke volume by delivering a small amount of fluid in a short…
- Trial name
- NCT04928040
- Testing
- Measurement of optic nerve sheath diameter
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Sepsis
Ultrasound Optimization of Initial Fluid Challenge in Sepsis
Initial sepsis treatment requires fluid challenge. While the Surviving Sepsis Campaign indicates a 30 ml/kg volume, there is concerns on the efficacy and safety of this fixed volume.
- Trial name
- echosepsis (NCT04028102)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Surgery
Haemodynamic and Respiratory Effects of a Low Positive End Expiratory Pressure Associated With a Fluid Challenge in Knee-chest Position
The genu pectoral position is a surgical position used for spine surgery. This surgical position will lead to physiological hemodynamic and respiratory changes during the procedure.
- Trial name
- OPTIPEP (NCT06378710)
- Testing
- Optimized PEEP
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Caen
Acute Circulatory Failure
Peripheral Tissue Perfusion in Intensive Care
Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care. However, little is known about the effects of different hemodynamic interventions performed in clinical routine on…
- Trial name
- INPPEREA (NCT06384287)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluid Overload, Mechanical Ventilation
Tidal Volume Challenge to Assess Volume Responsiveness
The purpose of this study is to investigate the ability of changes in PPV and SVV after Tidal Volume Challenge to predict fluid responsiveness in patients undergoing general anesthesia with protective mechanical ventilation.
- Trial name
- NCT05254951
- Testing
- Tidal Volume Challenge
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Fluid Overload, Cardiac Surgery
Fluid Responsiveness in Post-cardiac Surgery
the study aims to examine the validity of combined end-expiratory and end-inspiratory occlusion test and tidal volume challenge test for prediction of fluid responsiveness in immediate post-cardiac surgery patients
- Conditions
- Fluid Overload, Cardiac Surgery, Postoperative Complications
- Trial name
- NCT05957003
- Testing
- Combined end-expiratory occlusion and end-inspiratory occlusion test, Tidal volume challenge test
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Hemodynamic Instability, Shock
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially.
- Conditions
- Hemodynamic Instability, Shock, Septic Shock
- Trial name
- VOLTA (NCT04089098)
- Testing
- passive leg raising versus mini volume challenge
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Leipzig
Interventional Radiology, Surgery
Dynamic Estimation of Cardiac Output in the Operating Room
During major surgery, it is recommended to monitor invasive arterial blood pressure and cardiac output (CO) during hemodynamic interventions (fluid challenge or vasopressors).
- Conditions
- Interventional Radiology, Surgery, General Anesthesia, Organ Failure
- Trial name
- TRIPLEFLOW (NCT04926220)
- Testing
- Trans-esophageal Doppler monitoring, MostCareUP Haemodynamic Monitor, Argos Cardiac Output (CO) Monitor
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgery, Cardiac Output, Low
Reliability of a New Pulse Contour Technique for Diagnosing an Increase in Stroke Volume During a Fluid Challenge for Hemodynamic Optimization in Patients Scheduled for High-risk Abdominal Surgery: Comparison With Transthoracic Echocardiography: COMPARE Study
The present study aims at assessing the ability of a new pulse contour device for diagnosing a >15% stroke volume (SV) increase during patient hemodynamic optimization by fluid challenge in high risk abdominal surgery.
- Trial name
- COMPARE (NCT04871620)
- Testing
- >15% SV increase during fluid challenge
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Neurosurgery in Sitting Position
Dynamic Preload Indicators in Sitting Position
Intraoperative optimization of cardiac output using goal directed fluid challenge is associated with better outcome. Dynamic preload dependence indicators are well validated during surgery in supine position.
- Trial name
- NCT02000570
- Testing
- Sitting position (neurosurgery)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
Fluid Responsiveness Predictability
Hemodynamic Response to the End-expiratory Occlusion Test to Titrate Fluid Challenge in Operating Room.
Personalzing intraoperative anesthetic fluid management may help in preventing fluid accumulation and related complications. Fluids are gine as boluses in operating room (the so-called FC).
- Trial name
- FC_EEOT (NCT06627907)
- Testing
- fluid challenge, end-expiratory occlusion test
- Volunteers
- 300 people
- Sponsor
- Humanitas Clinical and Research Center