Clinical trials: Fluid Balance
Fluid Balance
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention.
- Trial name
- NCT06654557
- Testing
- 0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only), 0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only), 1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Weight Bias, Weight Change
Fluid vs Weight 24 Hour Balance
Daily Fluid Balance vs Weight Change
- Conditions
- Weight Bias, Weight Change, Fluid Balance, Fluid Accumulation
- Trial name
- Bilance24 (NCT07474116)
- Testing
- Daily Weight and fluid balance change
- Volunteers
- 55 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Hemodialysis
Copeptin Concentration Measured in Plasma Samples and Intradialytic Blood Pressure Variation
Vasopressin is a key regulator of water and vascular homeostasis, acting through V2 receptors to control renal water reabsorption and through V1a receptors to influence vascular tone.
- Trial name
- CODIALHYP (NCT07438925)
- Testing
- Routine biology samples et blood pressure mesures
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Delayed Extubation, Postoperative Intensive Care
Factors Associated With Late Extubation in Postoperative Patients in the Surgical Intensive Care Unit
Timely removal of a breathing tube after surgery is an important part of recovery for patients admitted to the intensive care unit (ICU).
- Conditions
- Delayed Extubation, Postoperative Intensive Care, Mechanical Ventilation Weaning
- Trial name
- NCT07658456
- Testing
- No Intervention - Retrospective Observational Study
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Kaohsiung Armed Forces General Hospital
Septic Shock, Sepsis
Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care
The purpose of this trial is to o assess feasibility of a protocol comparing conservative (trigger guided) vs. liberal (target guided) approach to fluid resuscitation in patients with septic shock after initial fluid…
- Trial name
- CLASSIC (NCT02079402)
- Testing
- Isotonic crystalloids
- Where
- 9 sites in Denmark, Finland
- Volunteers
- 153 people
- Sponsor
- Anders Perner
Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload
The Efficient PICU Fluid Care Evaluation
The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are: 1.
- Conditions
- Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload, Fluid Balance
- Trial name
- LESSER-2 (NCT06644508)
- Testing
- Strict adherence to European guidelines
- Where
- 3 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Heart Defects,Congenital, Heart Septal Defects, Atrial
Fluid Balance During Closure of Atrial Septal Defect
This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and…
- Trial name
- NCT01757743
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- Oslo University Hospital
Colonoscopy, Bowel Preparation
Acid-base Balance in Patients Undergoing Colonoscopy
The purpose of this study is to determine whether fluid administration in patients undergoing colonoscopy should affect acid-base disorder in term of the strong ion differences.
- Trial name
- NCT01250886
- Testing
- Lactated Ringer's solution, Normal saline solution, Acetate Ringer's solution
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Rate of Water Appearance/Delivery in the Blood, Water Balance
Effects of Drink Composition on the Appearance of Ingested Water in Body Fluids
To determine the effects of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials.
- Trial name
- NCT04509388
- Testing
- Composition of Sports Drink
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Healthy
"Beverage Hydration Index" of Commercial Therapeutic Beverages
The "beverage hydration index" (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric.
- Trial name
- NCT03262597
- Testing
- enterade, Pedialyte, Gatorade
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Sonoma State University
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Water Balance Disorders, Dehydration
The Jugular Vein Ultrasonography for Hydration Assessment in Healthy Participants
The aim of this cross-sectional, descriptive analysis is to compare 3 different ultrasound-based protocols to measure the internal jugular vein pressure (uJVP) in healthy individuals.
- Conditions
- Water Balance Disorders, Dehydration, Hypervolemia
- Trial name
- NCT06706960
- Testing
- measurement of IJV-height
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Nutrition, Healthy Male and Female Subjects
Influence of Food Texture on Appetite Control, Gastric Emptying, and Energy Expenditure
The aim of the study is to investigate the effect of liquid versus semi-solid meals on the regulation of energy balance in healthy young adults.The main questions it aims to answer are: Does a protein-rich liquid meal result in…
- Trial name
- NCT06853249
- Testing
- liquid meal, semi-solid meal, caloric drink + semi-solid meal
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Septic Shock
Utility of Sodium Lactate Infusion During Septic Shock
ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients
- Trial name
- ULIS1 (NCT03528213)
- Testing
- Sodium Lactate light dose, Sodium Lactate high dose, Normal saline
- Where
- 7 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Surgery, Colorectal
Perioperative Colloid vs Crystalloid in Patients Undergoing Colorectal Surgery
The primary purpose of this study is to determine the effect of a balanced 6%hydroxyethyl starch 130/0.4 vs. a balanced crystalloid in colorectal surgery.
- Trial name
- KoKris (NCT01303250)
- Testing
- balanced 6% hydroxyethylstarch 130/0.4, balanced crystalloid
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Muenster
Chest Trauma, Fluid Balance; Disorder
Chest Trauma :Prediction of Thoracic Injuries Clinically and Radiologically
Trauma is a major cause of morbidity and mortality worldwide. Despite the advent of specialized trauma centers the outcome of patients who sustain major trauma remains disappointing.
- Trial name
- chesttrauma (NCT03686579)
- Testing
- chest trauma
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dehydration, Rehydration
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Dehydration lowers both physical and mental performance if it is severe enough. Performance declines are more pronounced in hot conditions or after prolonged strenuous activity such as exercise.
- Conditions
- Dehydration, Rehydration, Exercise Performance, Exercise Recovery
- Trial name
- NCT05428761
- Testing
- TP1, TP2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.
Traumatic Brain Injury, Fluid Overload
Neutral Versus Liberal fLuId In Traumatic Brain Injury: a Randomised Controlled Trial
Feasibility and safety of targeting neutral vs liberal fluid balance in traumatic brain injured patients: a phase II randomized controlled trial
- Conditions
- Traumatic Brain Injury, Fluid Overload, Outcome, Fatal
- Trial name
- LIMIT (NCT05983549)
- Testing
- fluid balance
- Volunteers
- 80 people
- Sponsor
- Universita degli Studi di Genova