Clinical trials: Flow-mediated Dilation
Metabolic Syndrome
Mesoglycan, Vascular Reactivity and Metabolic Syndrome
The purpose of the study was to characterize the action of mesoglycan on vascular endothelium through the non-invasive assessment of vascular reactivity humeral artery by comparing effects of mesoglycan on Flow Mediated…
- Trial name
- NCT02254850
- Testing
- Flow Mediated Dilation, Mesoglycan
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Vascular Function
Flow Mediated Dilation in Response to Black Tea
Research indicate that people who regularly drink tea have a reduced risk of stroke or heart disease. In a number of studies in which people that normally do not drink showed that their blood vessels function improved when the…
- Trial name
- T (NCT02273323)
- Testing
- Tea
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Unilever R&D
Endothelial Dysfunction, Type 2 Diabetes Mellitus
Effects of Benfotiamine and AGE on Endothelial Function in People With Diabetes
The purpose of the study is to determine whether there are differences in postprandial endothelial function following a high-AGE(Advanced Glycation End-products) meal vs. a low-AGE meal.
- Trial name
- AGE-Benfo (NCT00437008)
- Testing
- Benfotiamine 1050mg, 3 days, high-AGE vs. low-AGE meal
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Ruhr University of Bochum
Normal Weight Obesity, Metabolically Obese Normal Weight
Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud
Metabolically Obese Normal Weight (MONW) represents a phenotype affecting individuals with a normal Body Mass Index (BMI) but characterized by excessive adipose tissue accumulation.
- Conditions
- Normal Weight Obesity, Metabolically Obese Normal Weight, Metabolic Syndrome
- Trial name
- NCT07358533
- Where
- Poland
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Obesity, Hypertension
Flow-mediated Arterial Dilatation, Hypertension, Endothelin-1 and sICAM-1 in Obese Adolescents
Obesity in adolescents is associated with the development of cardiovascular disease and type 2 diabetes mellitus. In order to detect early development of cardiovascular disease, early detection of the endothelium of obese…
- Conditions
- Obesity, Hypertension, Adolescent Obesity
- Trial name
- sICAM-1 (NCT05951894)
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Vasodilation
An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men
Aim: To investigate the dose-dependent vascular effect (primarily using FMD) of 3 low-level doses of pure (-)-epicatechin ≤ 1 mg/kg BW (0.1, 0.5 \& 1.0 mg/kg BW) in healthy men.
- Trial name
- NCT02292342
- Testing
- Water, Epicatechin 0.1 mg/kg, Epicatechin 0.5 mg/kg
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Reading
Coronary Artery Disease
Biomarkers for Cardiovascular Disease
Biomarkers for Cardiovascular Disease Summary: This study will examine the function of the lining cells of blood vessels and measure substances in the blood to see how they relate to various blood tests, including new tests under…
- Trial name
- NCT00109018
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Blood Pressure
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
Ginseng has been used for many years in a wide array of anecdotal medicinal properties. Animal and limited clinical research points to the vascular effects of Korean Red Ginseng (KRG).
- Conditions
- Hypertension, Blood Pressure, Endothelial Function
- Trial name
- ESGC (NCT00728221)
- Testing
- Korean Red Ginseng, Korean Red Ginseng (Panax ginseng), Cornstarch
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Atheroma
Periodontal Therapy in Coronary Artery Patients
Gingival inflammation has been associated with cardiovascular diseases, including heart attack and stroke, because of elevation of blood risk markers such as cholesterol, glucose and C reactive protein.
- Conditions
- Cardiovascular Diseases, Atheroma, Coronary Artery Disease
- Trial name
- PerioCardio (NCT01609725)
- Testing
- Subgingival scaling and root planing, Oral prophylaxis
- Where
- Brazil
- Volunteers
- 93 people
- Sponsor
- Federal University of Rio Grande do Sul
Obesity, Cardiovascular Diseases
High-intensity Exercise Training or Multidisciplinary Treatment in Extremely Obese Adolescents
The aim of the present study was to determine the effects of a multidisciplinary approach and intensity-controlled interval training on cardiovascular risk factors in overweight adolescents
- Trial name
- NCT00682266
- Testing
- intensity controlled interval training (AIT), Multidisciplinary approach (MTG)
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Smoking
Endothelial Function and Autonomic Regulation After Short-term Smoking Cessation: Varenicline Versus Placebo
The purpose of this study is to evaluate endothelial function and autonomic regulation (for example, heart rate and blood pressure) in smokers before and after short-term smoking cessation.
- Trial name
- NCT00673595
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Sauna Bathing to Improve Vascular Health of Adults With Heart Disease
This study is a clinical trial that will determine if sauna bathing improves blood vessel health in adults aged 50-70 years with heart disease.
- Trial name
- NCT03620539
- Testing
- Lifestyle intervention
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Montreal Heart Institute
Borderline High LDL-cholesterol
Effects of Ubiquinol and Ubiquinone on Vascular Function in Healthy Adults With Borderline High LDL-Cholesterol
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of Ubiquinol and Ubiquinone on vascular endothelial function in generally healthy adults with borderline high LDL-cholesterol.
- Trial name
- NCT07881601
- Testing
- Ubiquinol, Ubiquinone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
COVID-19, Chronic Heart Failure
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Aim of this prospective, interventional, single-center, randomized study is to evaluate the efficacy and safety of intermittent hypoxic-hyperoxic training (IHHT) as a rehabilitation method in patients with cardiovascular…
- Conditions
- COVID-19, Chronic Heart Failure, Hypertension, Arrhythmia
- Trial name
- NCT05379608
- Testing
- Intermittent hypoxic-hyperoxic training, Intermittent hypoxic-hyperoxic training/control
- Where
- Russia
- Volunteers
- 43 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Smoking Cessation, Brachial Flow Mediated Dilatation
Smoking Cessation in a Cohort HIV+ Rio de Janeiro, Brazil.
The study was carried out within a large, urban prospective cohort of PLHIV at the Instituto Nacional de Infectologia Evandro Chagas (INI).
- Conditions
- Smoking Cessation, Brachial Flow Mediated Dilatation, Nicotine Replacement Therapy
- Trial name
- NCT05873738
- Testing
- Nicotine replacement
- Where
- Brazil
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Cardiovascular Disease, Endothelial Dysfunction
Effect of Homocysteine-lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease
Endothelial dysfunction is an early marker of atherosclerosis and is found in patients (pts) with coronary (CAD) and peripheral artery disease (PAD).
- Trial name
- NCT00693589
- Testing
- folic acid, vitamin B12 and B6 and rosuvastatin
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperglycemia, Postprandial, Overweight and Obesity
Ketone Supplementation, Glucose Control, and Cardiovascular Function
Post-prandial hyperglycemic excursions induce a cascade of deleterious effects on the body, including increased inflammation, production of reactive oxygen species, and impaired cardiovascular function.
- Conditions
- Hyperglycemia, Postprandial, Overweight and Obesity, Diabetes Mellitus Risk
- Trial name
- NCT03817749
- Testing
- Exogenous ketone monoester
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Type 2 Diabetes Mellitus, Endothelial Dysfunction
Acute Effects of Sildenafil on Endothelial Function in People With Diabetes
This is a double-blind, placebo-controlled, cross-over trial using a single dose of 100 mg sildenafil or placebo in 40 subjects with T2DM without known cardiovascular disease.
- Trial name
- NCT00527995
- Testing
- Sildenafil
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ruhr University of Bochum
Endothelial Dysfunction
Maraviroc Abacavir STudy - Effect on Endothelial Recovery
HIV infected patients treated with abacavir might have a higher risk for the occurrence of cardiovascular events. At time of writing of this protocol the underlying mechanism is not yet elucidated, however some studies find…
- Trial name
- MASTER (NCT01389063)
- Testing
- Maraviroc
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- S.F.L. van Lelyveld