Clinical trials: First-Episode Psychosis
Psychosis
Effects of Online Metacognitive Training Group on Distressing Beliefs
Psychosis is characterized by distorted perceptions of reality, often involving persecutory delusions. Research links these symptoms to cognitive biases like "jumping to conclusions." Despite mixed reviews of Cognitive Behavioral…
- Trial name
- NCT06703827
- Testing
- The metacognitive training group
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- City, University of London
First-Episode Psychosis, Bipolar Disorder
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI
Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.
- Trial name
- CARB (NCT02334904)
- Testing
- Aripiprazole, Risperidone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cannabis-Related Disorder, Substance-Related Disorders
First Episode Schizophrenia and Cannabis-Related Disorder Study
Many individuals with schizophrenia abuse cannabis at the onset of their illness, portending a poorer course of illness and poorer treatment response.
- Conditions
- Cannabis-Related Disorder, Substance-Related Disorders, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00573287
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
First Episode Psychosis (FEP)
Use of Parent Connectors in First Episode Psychosis (FEP)
This study proposes to adapt an evidence based peer parent navigator (PPN) intervention, called Parent Connectors, in which trained and supervised PPNs deliver weekly telephone-based support for six to nine months to parents or…
- Trial name
- NCT04018521
- Testing
- PPN, CSC Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
First Episode Psychosis of Schizophrenia and Schizotypal Disorder, Psychotic Disorders
Extended Specialized Assertive Intervention for First Episode Psychosis
In a randomized clinical trial, the researchers want to investigate if the positive short-term outcomes (first 1-2 years), achieved with specialized assertive intervention programme (OPUS), can be maintained for five years if the…
- Conditions
- First Episode Psychosis of Schizophrenia and Schizotypal Disorder, Psychotic Disorders, Schizophrenia, Schizoaffective Disorder
- Trial name
- OPUSII (NCT00914238)
- Testing
- 2 years OPUS treatment, OPUS 5 years
- Where
- 2 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- University of Copenhagen
Schizophrenia
The Danish Region Midt Schizophrenia Cohort
The objective of this study is to recruit patients at the first diagnosis with a schizophrenia spectrum disorder (SSD) and ultra-high risk patients (UHR), defined as patients with drug abuse and psychotic symptoms indicating a…
- Trial name
- RMS (NCT06431009)
- Testing
- Treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 350 people
- Sponsor
- University of Aarhus
First-Episode Psychosis
Trial to Increase FEP Attendance
Individuals with first-episode psychosis (FEP) are at high-risk for several poor functional and clinical outcomes, including suicide.
- Trial name
- NCT05967195
- Testing
- Financial Incentive and Text-Messages
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Smoking, Psychosis
A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis
The investigators propose to recruit patients who have experienced a recent first episode of psychosis who have a chart diagnosis of Schizophrenia, Schizophrenifom, Schizoaffective Disorder, Psychosis NOS, or Bipolar I Disorder…
- Trial name
- NCT01399112
- Testing
- Web-based computer program
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwell Health
First-episode Psychosis
HIIT in Patients With a First-episode Psychosis
This study aims to estimate the effect of a 3-month High Intensity Interval Training on antipsychotic-induced weight gain in patients with a first episode of psychosis, as well as to determine whether these effects are maintained…
- Trial name
- NCT04792476
- Testing
- High Intensity Interval Training
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Intervención Temprana en Psicosis de Cantabria (ITPCan)
Schizophrenic Disorders
Psychological Intervention for Relapse Prevention in First Episode Schizophrenia
The study is a randomized clinical trial investigating the efficacy of a comprehensive psychological intervention for the treatment of first episode schizophrenia
- Trial name
- NCT00161408
- Testing
- cognitive behavioural therapy, psychoeducation
- Where
- 5 sites in Germany
- Volunteers
- 106 people
- Sponsor
- University Hospital Tuebingen
Bipolar Disorder, Schizoaffective Disorder
Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features
Aim: In a population of first episode manic patients with psychotic features, we want to compare the side effect profile, the degree of adherence and the subjective well being, as well as the efficacy of two treatments: The…
- Trial name
- NCT00202293
- Testing
- Olanzapine, Lithium, Chlorpromazine
- Where
- Australia
- Volunteers
- 83 people
- Sponsor
- Melbourne Health
Psychosis
Relationship Between Efficacy of Lumateperone and Brain Glutamate and Dopamine
This study will examine the differential relationships between antipsychotic efficacy and changes in dopaminergic and glutamatergic brain metabolism in lumateperone and risperidone treated early psychosis patients.
- Trial name
- Lumafep (NCT05890768)
- Testing
- Lumateperone, Risperidone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Schizophrenia
Early Medication Discontinuation and Long-term Clinical Outcome in FEP
The study aims to examine the relationship between early maintenance therapy decisions in first episode psychosis, and the subsequent long-term clinical outcome at 9-10 years by comparing a group of patients who were randomized…
- Trial name
- FEP (NCT01926340)
- Where
- Hong Kong
- Volunteers
- 178 people
- Sponsor
- Professor Eric Y.H. Chen
Schizophrenia, Bipolar Disorder
Integrated Care Including Assertive Community Treatment in Early Psychosis
Improvement of clinical long-term outcome through the implementation of early detection and intervention within a specialized network of integrated care (ACT and hometreatment) for adolescents and young adults with a first…
- Trial name
- ICEP (NCT02037581)
- Testing
- Early detection and Integrated Care, Standard Care
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Schizophrenia
Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies
Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis.
- Trial name
- PEPsy (NCT02670447)
- Testing
- MRI
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Schizophrenia
cTBS on First-episode Drug Naive Patients With Schizophrenia
cTBS is a promising novel intervention, which have strong potentials on moderating disease syndrome, suck as verbal hallucination, and cognitive deficits in schizophrenia, as it has been proved for the treatment of depression.
- Trial name
- NCT05086133
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Central South University
Schizophrenia (Recent-onset)
Oral Risperidone Versus Injectable Paliperidone Palmitate for Treating First-Episode Schizophrenia
This study will determine the efficacy of oral risperidone (Risperdal) versus long-acting injectable paliperidone palmitate (Invega Sustenna) in treating people with first-episode schizophrenia.
- Trial name
- NCT01451736
- Testing
- paliperidone palmitate, risperidone
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
First Episode Psychosis
Early Intervention Psychosis Communication and Engagement Trial
This study will examine whether or not the use of digital communication methods (text messages and emails) improves patient engagement with Early Intervention Psychosis (EIP) Services, compared to standard communication methods…
- Trial name
- NCT03196128
- Testing
- Digital communication, Non digital
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South London and Maudsley NHS Foundation Trust
Schizophrenia, Schizophrenia Relapse
3-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals
This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the three years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with…
- Conditions
- Schizophrenia, Schizophrenia Relapse, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- ADARFEP (NCT02220504)
- Testing
- Antipsychotic treatment discontinuation, Maintenance antipsychotic treatment
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Fundación Marques de Valdecilla