Clinical trials: First Trimester Abortion
Blood Loss
Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women
The primary objective of this study is to compare blood loss resulting from surgical termination of pregnancy up to 12 weeks gestation between women who are anticoagulated to therapeutic levels and those who are not…
- Trial name
- NCT00614432
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Undesired Intrauterine Pregnancy, First Trimester Pregnancy
Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions
In the United States, the majority of first-trimester surgical abortions are performed in outpatient clinics that utilize a wide variety of oral and intravenous regimens for pain control.
- Trial name
- NCT01011634
- Testing
- Intravenous moderate sedation versus oral medication
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion, Spontaneous, Abortion in First Trimester
Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o
The investigators are conducting a study on pain control for dilation and curettage (D\&C). Participants are eligible to enroll if they are a planning to have a D\&C in a participating clinic.
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early
- Trial name
- NCT03636451
- Testing
- 40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Infertility, Female, First Trimester Spontaneous Abortion
Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.
This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting.
- Trial name
- NCT04387994
- Testing
- Blood samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Missed Abortion
Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
The purpose of this study is to determine the effectiveness of buccal misoprostol and comparing this with vaginal route of the same drug.
- Trial name
- NCT00892229
- Testing
- Misoprostol (given buccally), Misoprostol (given vaginally)
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Undesired Pregnancy
Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)
The main objective of this study is to determine the equivalency of oral conscious sedation and intravenous conscious sedation for first trimester surgical abortion.
- Trial name
- NCT00337792
- Testing
- oxycodone + lorazepam versus fentanyl + midazolam
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Pregnancy, Unwanted
Self-Administered Lidocaine Gel for Pain Management With First Trimester Surgical Abortion: A Randomized Controlled Trial
Despite global efforts to decrease discomfort during surgical abortion, pain remains a limiting factor in where and how procedures are performed.
- Trial name
- SALSA (NCT02447029)
- Testing
- vaginal 2% Xylocaine, standard lidocaine paracervical block
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain, Surgical Abortion
Paracervical Block in First Trimester Surgical Abortions
The investigators primary objective is to study the analgesic effects of combined ketorolac and lidocaine in a paracervical block compared to preoperative ibuprofen followed by intra-operative paracervical block with lidocaine…
- Trial name
- NCT00617097
- Testing
- lidocaine, ketorolac and lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Abortion, First Trimester
Acceptability and Feasibility of Medical Abortion Using Mifepristone and Buccal Misoprostol
This study examined the acceptability and feasibility of introducing a mifepristone-misoprostol regimen of medical abortion into abortion services in two private clinics in Puerto Rico; 2 clinics in Baku, Azerbaijan; 3 clinics in…
- Trial name
- NCT00386282
- Testing
- mifepristone-misoprostol treatment
- Where
- 11 sites in Armenia, Azerbaijan and 2 more
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion in First Trimester, Pain, Procedural
Ketamine Versus Fentanyl for Surgical Abortions
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and…
- Conditions
- Abortion in First Trimester, Pain, Procedural, Opioid Use
- Trial name
- NCT04871425
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Medical; Abortion, Fetus
Fertility and Obstetric Outcomes After Medical Management Versus Surgical Treatment for First-trimester Miscarriage First-trimester Miscarriage
Study Objective: To compare the time to new pregnancy and pregnancy outcomes in women who received Misoprostol for uterus evacuation versus those treated surgically with dilatation and curettage.
- Trial name
- NCT03570307
- Testing
- medical VS surgical evacuation of the uterus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Abortion, Induced, Pain
Paracervical Versus Intracervical Lidocaine
The aim of this study is to estimate the efficacy of intracervical versus paracervical block on pain experienced during first trimester suction curettage without the use of preoperative cervical ripening.
- Trial name
- NCT00816751
- Testing
- Paracervical block, Intracervical, Buffered Lidocaine, vasopressin, sodium bicarbonate
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion, Induced
Different Routes of Misoprostol Prior to First Trimester Surgical Abortion
A randomized clinical trial to assess the effectiveness of same-day cervical preparation with oral, buccal or vaginal Misoprostol, given 2-4 hours prior first trimester curettage.
- Trial name
- NCT02480543
- Testing
- Misoprostol (cytotec)
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Pain
Lidocaine and Pain Management in First Trimester Abortions
The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidocaine injected on either side of the…
- Trial name
- NCT00613821
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pregnancy, Unplanned
Use of an Algorithm to Determine IV Sedation Dosing During First-trimester Surgical Abortion
This study aims to compare an algorithm for IV sedation dosing to the current standard of care in patients undergoing first trimester surgical abortion.
- Trial name
- NCT01994317
- Testing
- Algorithm, Standard care
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Placenta; Implantation
The Accuracy of Ultrasound in the Detection of Placenta Site in the First Trimester.
The investigators speculate that ultrasound examination in the first trimester can accurately detect placental location. By performing both transabdominal ultrasound and later hysteroscopy on women with a first trimester missed…
- Trial name
- NCT04579796
- Testing
- ultrasound exam, hysteroscopy diagnostic
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pain Score
Comparison of Lidocaine Spray and Paracervical Block Application for Pain Relief During First-trimester Surgical Abortion: a Randomized, Double-blind, Placebo-controlled Trial
Objective: The investigators sought to investigate the analgesic efficiency of lidocaine spray, paracervical block (PCB) with lidocaine and PCB with lidocaine plus lidocaine spray combination in patients undergoing…
- Trial name
- NCT02007408
- Testing
- Paracervical block, Lidocaine spray, Paracervical block + lidocaine spray
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Missed Abortion, Medical; Abortion, Fetus
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.
- Conditions
- Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion
- Trial name
- NCT05342467
- Testing
- Gemeprost 1 Mg Vaginal Pessary, Dinoprostone 3 mg
- Where
- 2 sites in Malaysia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Induced Abortion
Is Oxytocin Given During Surgical Procedure for Abortion Before 12 Weeks of Pregnancy Useful?
This is a randomized, single-blind study using oxytocin 5U i.v. during surgical abortion in one arm of the study, and no medication in the other arm of the study.
- Trial name
- oxystudien (NCT00540748)
- Testing
- oxytocin
- Where
- Norway
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Asker & Baerum Hospital
Early Pregnancy Loss, Delayed Pregnancy Loss
CCT-102 or Expectant Management in Delayed Pregnancy Loss
A Phase 3, multi-center clinical trial of a CCT-102 regimen or expectant management to promote uterine evacuation in first trimester non-progressing Delayed Pregnancy Loss (DPL).
- Trial name
- MERMAID (NCT06121063)
- Testing
- CCT-102 A and CCT-102 B
- Where
- 15 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC