Clinical trials: First Responders
Need to Refer the Patient to the Hospital Emergency Department
Artificial Intelligence Triage of Patients Requiring Emergency or Unscheduled Care Who Need to be Referred to Hospital
For several decades, hospital emergency departments have been experiencing congestion, sometimes reaching saturation point, where they are no longer able to fulfil their primary mission: to prioritise patients requiring immediate…
- Trial name
- TRIAGE (NCT07428109)
- Where
- France
- Volunteers
- 40,680 people
- Sponsor
- SOS Médecins Grand Paris
Trauma, Injury
Data-Driven Lay First Responder Program in Cameroon
Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system.
- Trial name
- K-LFR Project (NCT07581327)
- Testing
- Lay First Responder (LFR) training
- Where
- Cameroon
- Volunteers
- 1,812 people
- Sponsor
- Sabrinah Christie
Cardiac Arrest
Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER)
The study compares the effectiveness of two fully approved shock waveforms (monophasic and biphasic shock) commonly used to defibrillate (shock) patients with out-of-hospital cardiac arrest due to a highly lethal rhythm problem…
- Trial name
- NCT00101881
- Testing
- Defibrillation (biphasic versus monophasic shock)
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Washington
PTSD - Post Traumatic Stress Disorder
ONE-P TMS First Responders
The aim of this study is to examine the feasibility and tolerability of a one-day protocol of repetitive transcranial magnetic stimulation with D-cycloserine (DCS) as an augmentation strategy in first responders who have PTSD.
- Trial name
- ONE-P_FR (NCT07773935)
- Testing
- D-Cycloserine (DCS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA
Post-Traumatic Stress Disorder, Adjustment Disorders
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First Responders
The purpose of this study is to assess the safety and efficacy of MDMA-Assisted Therapy on Frontline Health Care Workers and First Responders suffering from symptoms of Post-Traumatic Stress.
- Trial name
- NCT05455996
- Testing
- MDMA
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nautilus Sanctuary
PTSD - Post Traumatic Stress Disorder
Evaluating Evidenced Based Options for PTSD Treatment
This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.
- Trial name
- NCT06733376
- Testing
- Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Rush University Medical Center
Post Traumatic Stress Disorder
eTMS for Veterans and First Responders With PTSD
A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD.
- Trial name
- NCT06294106
- Testing
- Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University
Post Traumatic Stress Disorder
Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers
This study addresses PTSD symptoms in First Responders and Healthcare workers. Specifically, it tests whether a brief PTSD treatment (talk therapy) effectively treats PTSD when provided to First Responders and Healthcare workers…
- Trial name
- NCT05751473
- Testing
- Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU)
- Where
- 14 sites in United States
- Volunteers
- 410 people
- Sponsor
- University of Michigan
Post Traumatic Stress Disorder, Cognitive Deficit
Investigating the Use of Goal Management Therapy in Improving Cognitive Functioning in Public Safety Personnel With PTSD
This study examines the efficacy of Goal Management Therapy (GMT) - a well-established cognitive remediation strategy aimed at improving goal-directed behaviors that are dependent on basic cognitive processes and on executive…
- Trial name
- NCT04251624
- Testing
- Goal Management Therapy, Psychosocial Education
- Where
- Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Homewood Research Institute
Cardiac Arrest (CA)
The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region
Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency and one of the leading causes of death worldwide. Survival depends critically on how quickly help arrives and whether cardiopulmonary resuscitation (CPR) and…
- Trial name
- FIRSST-RER (NCT07589504)
- Where
- Italy
- Volunteers
- 5,200 people
- Sponsor
- Azienda Usl di Bologna
Ventilation
Bag-Valve-Guedel Adaptor Vs Common Face Mask for the Ventilation of Anesthetized Bearded Men
Ventilation of a bearded patient with the commonly used face mask has low efficiency because of difficulties to achieve a tight seal around the mouth and nose.
- Trial name
- BVGA02 (NCT04376918)
- Testing
- Begin with BVGA, Begin with Face-mask
- Where
- Israel
- Volunteers
- 101 people
- Sponsor
- Hebrew University of Jerusalem
Aphasia
First Responder Aphasia Strategy Training
This study aims to determine the impact of a collaborative approach to training law enforcement officers and first responders about aphasia including their knowledge and confidence in communicating with individuals with aphasia…
- Trial name
- NCT06678854
- Testing
- Training about Aphasia
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiac Structure and Function, Intracardiac Hemodynamic
Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders
The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions.
- Trial name
- IHMS (NCT06075342)
- Testing
- exercise
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Compassion Fatigue, Burnout
Resilience Training for First Responders in the Opioid Epidemic
First responders (law enforcement, firefighters, and emergency medical system personnel) are subjected to daily pressures from their duties with resultant compassion fatigue, burnout, anger, poor mental and physical health…
- Conditions
- Compassion Fatigue, Burnout, Stress, Mindfulness
- Trial name
- NCT04929613
- Testing
- Mindfulness-Based Resilience Training
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Breast Adenocarcinoma
Assessing Combined SBRT in Breast Cancer Non-Responders to Neoadjuvant Chemotherapy
The goal of this clinical trial is to assess whether the addition of preoperative stereotactic body radiation therapy (SBRT) can improve pathological complete response (pCR) rates and safety in breast cancer patients who do not…
- Trial name
- NCT06596018
- Testing
- SBRT, Chemotherapy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Occupational Exposure to SARS-CoV-2, COVID-19
COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers
The COVID-19 CHAMPS Study will obtain data on the physical and mental health and well-being of workers potentially exposed to the SARS-CoV-2 virus in the course of their duties.
- Trial name
- CHAMPS (NCT04370821)
- Where
- United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Villanova University
Healthy Adult
Testing of Personal Protective Equipment (PPE) for First Responders
The purpose of this pilot study is to improve protection of first responders in case of biological disasters (e.g., pandemics, biotoxin incidents).
- Trial name
- NCT07726537
- Testing
- Category III PPE suit "COMAT (Matisec, France)", Category III PPE Suit "EBO-10 (EGO, Czech Republic)"
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
PTSD
Residential Retreat for Veterans and First-responders
The purpose of this study is to determine the potential efficacy and feasibility of a residential retreat program to address PTSD symptoms in Veterans and First-responders
- Trial name
- NCT05311696
- Testing
- psychoeducation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Valhalla Project Niagara
Out-Of-Hospital Cardiac Arrest
First Responder Airway & Compression Rate Trial
The First responder Airway \& Compression rate Trial (FACT) Study will address basic life support (BLS) treatments administered by Emergency Medical Services (EMS) first responders to patients who suffer a sudden circulatory…
- Trial name
- FACT (NCT05969028)
- Testing
- igel, Compression Rate
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder, Depression
The Pitt Center for Emergency Responder Wellness
Emergency responders protect the public despite occupational hazards that threaten their mental health. The Pitt Center for Emergency Responder Wellness will be a clinical innovation hub that: 1) delivers accessible interventions…
- Conditions
- Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
- Trial name
- NCT05357586
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh