Clinical trials: Fever in Neutropenia
Fever, Neutropenia
Low-risk Fever and Neutropenia in Children With Cancer: Safety and Efficacy of Oral Antibiotics in an Outpatient Setting
The purpose of this study is to determine whether, in children with cancer presenting with fever in severe chemotherapy-induced neutropenia at low risk for medical complications, oral antibiotics in an outpatient setting after an…
- Conditions
- Fever, Neutropenia, Cancer
- Trial name
- NCT00107081
- Testing
- ciprofloxacin and amoxicillin, Outpatient management, i.v. antibiotics
- Where
- 12 sites in Germany, Netherlands and 1 more
- Volunteers
- 70 people
- Sponsor
- Swiss Pediatric Oncology Group
Febrile Neutropenia, Solid Tumors
The Oral Cavity as a Source of Febrile Neutropenia
Febrile neutropenia (FN) is a clinically important adverse effect of myelosuppressive chemotherapy. If patients present with FN, attention is focussed on well-recognized sites of origin of infection: the airways, urinary tracts…
- Conditions
- Febrile Neutropenia, Solid Tumors, Dental Infection, Oral Infection
- Trial name
- ORA-FEBRIS (NCT02702583)
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Febrile Neutropenia
Short Antibiotic Treatment in High Risk Febrile Neutropenia
Infections are a common complication in patients with cancer. They are a significant cause of complications and death in this population.
- Trial name
- NCT05786495
- Testing
- Early Discontinuation of Antibiotics, Standard of Care
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Cancer Childhood, Febrile Neutropenia
Clusterin, Ptx3 and Pediatric Febrile Neutropenia (CluPPFeN)
Febrile aplasia is a common occurrence in children/adults treated with chemotherapy for malignant blood diseases or solid cancers.
- Trial name
- CluPPFeN (NCT05584930)
- Testing
- Collection of blood sample
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Febrile Neutropenia
Evaluation of Intestinal Bacterial and Fungal Translocation and Intestinal Microbiota in Febrile Neutropenic Patients in Pediatric Onco-hematology
This pilot study aims to study intestinal bacterial and fungal translocation and the evolution of the intestinal microbiota in patients over the course of their medical surveillance to search for a link between dysbiosis and…
- Trial name
- TRANSNEUTROFEB (NCT03342365)
- Testing
- Evaluation of microbial translocation and microbiota
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Infection, Febrile Neutropenia
Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients
The aim of the study is to evaluate the efficacy and safety of Teicoplanin versus Vancomycin as part of the initial antibiotic regimen in the therapy of patients with fever and neutropenia .
- Trial name
- NCT00454272
- Testing
- Teicoplanin, Vancomycin
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Sanofi
Bloodstream Infection, Gram Negative Infections
Antibiotic Duration and Outcomes in High-Risk Febrile Neutropenia Patients
The goal of this clinical trial is to learn if a personalized duration of antibiotic therapy, based on clinical stability, is as effective as a standard duration of at least 10 days in hospitalized patients with hematologic…
- Conditions
- Bloodstream Infection, Gram Negative Infections, Bacteraemia Caused by Gram-Negative Bacteria, Febrile Neutropenia (FN)
- Trial name
- PERaSTrA (NCT07372131)
- Testing
- Clinical Stability-Driven Antibiotic Discontinuation Strategy, Standard of Care Antibiotic Duration
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- Valeria Cento
Septic Shock
Pentaglobin in CRE and PA Neutropenic Infections
To demonstrate that the early addition of Pentaglobin to the best available antimicrobial therapy is able to reduce mortality and improve survival in neutropenic febrile acute leukemia or allo- Hematopoietic stem cell…
- Trial name
- PENTALLO (NCT03494959)
- Testing
- Pentaglobin
- Where
- 20 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Febrile Neutropenia
Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia
Clinical trial intended to reduce the antibiotic therapy duration in "in-hospital" patients with haematological diseases who develop fever and low white blood cell count (neutropenia).
- Trial name
- HOWLONG (NCT01581333)
- Testing
- Empirical antimicrobial treatment discontinuation, Standard empirical antimicrobial treatment discontinuation
- Where
- 6 sites in Spain
- Volunteers
- 157 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Fever, Sweating
Daptomycin in Treating Neutropenia and Fever in Patients With Cancer
RATIONALE: Antibiotics, such as daptomycin, may control neutropenia, fever, and infection in patients with cancer. PURPOSE: This phase II trial is studying how well daptomycin works in treating neutropenia and fever in patients…
- Conditions
- Fever, Sweating, Hot Flashes, Infection
- Trial name
- NCT00335478
- Testing
- Daptomycin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- OHSU Knight Cancer Institute
Febrile Neutropenia
Prophylactic Use of PEG-rhG-CSF in Medium-high Risk of FN in Chemotherapy of Breast Cancer
This clinical study is a multiple center, registering and real-world conditional research. The breast cancer patients planning for chemotherapy evaluated with medium-high risk of febrile neutropenia (FN) are recruited, receiving…
- Trial name
- NCT03618810
- Testing
- PEGCSF first level prophylactic use, PEGCSF second level prophylactic use
- Volunteers
- 2,000 people
- Sponsor
- Zhejiang Cancer Hospital