Clinical trials: Fetuin-A
Hepatocellular Cancer, AFP Expressing Tumors
AFPᶜ³³²T in Advanced HCC
This first time in human study is intended for men and women between 18 and 75 years of age who have advanced liver cancer which has grown or returned after being treated or another AFP expressing tumor.
- Trial name
- NCT03132792
- Testing
- Autologous genetically modified AFPᶜ³³²T cells
- Where
- 21 sites in United States, France and 2 more
- Volunteers
- 39 people
- Sponsor
- Adaptimmune
Hepatocellular Carcinoma
Yliver as a Test to Early Diagnose HCC
Liver cancer (HCC) is the second cause of death related to cancer worldwide, with about 750,000 deaths from this cause in 2012. Although the early diagnosis of liver cancer increases the available treatment options, the methods…
- Trial name
- YliverDIAG (NCT03767764)
- Testing
- Test Yliver
- Where
- Spain
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Fatty Liver
Clinical Study of Serum Fetuin A Level, Insulin Resistance and Hepatic Fat Content in Dialysis Patients
Background Fetuin A, synthesized in hepatocyte, is a circulatory inhibitor of precipitation of calcium and phosphate and links to cardiovascular calcification and mortality in dialysis patients; besides, it is associated with…
- Trial name
- NCT01457625
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- Far Eastern Memorial Hospital
Gallbladder Cancer
Poorly Differentiated Adenocarcinoma With Signet Ring Cells of the Gallbladder Producing a High Level of Alpha-fetoprotein: a Case Report
Alpha-fetoprotein (AFP) can become elevated in hepatocellular carcinoma (HCC), yolk sac tumors and other malignant tumors of various organs.
- Trial name
- NCT05559229
- Testing
- laparoscopic whole-layer cholecystectomy
- Where
- Japan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- junya mita
Periodontal Diseases
Serum Amyloid A Protein And Fetuin A Levels
The purpose of this study was to evaluate acute phase proteins (APPs) Fetuin-A and Serum Amyloid A (SAA) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
- Trial name
- NCT02433405
- Testing
- Fetuin-A, Serum Amyloid A
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Gingivitis and Periodontal Diseases
Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study
The present clinico-biochemical study was carried out to estimate the levels of Fetuin A and MMP7 in serum of systemically healthy subjects in periodontal health and disease and to evaluate the impact of periodontal…
- Trial name
- NCT04198610
- Testing
- Non surgical periodontal therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Diabete Type 2
Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus
The aim of this study is to assess the significance of serum fetuin-A as a marker of obesity and type 2 diabetes mellitus. We used multiple statistical approaches to determine that the fetuin-A level is correlated to body mass…
- Trial name
- NCT04218305
- Testing
- Serum Level Of Fetuin A
- Volunteers
- 400 people
- Sponsor
- Minia University
Infertility, Infertility, Female
Follicular Fluid Fetuins in in Vitro Fertilization
This study aims to investigate whether follicular fluid concentrations of fetuin A and fetuin B are associated with the clinical pregnancy and live birth rates in in vitro fertilization (IVF) cycles.Twenty-nine women with poor…
- Trial name
- NCT04201847
- Testing
- Serum test
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Samsun Education and Research Hospital
Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma
A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of BGB-B2033 alone or in combination with tislelizumab, with or without…
- Conditions
- Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma, Alpha-fetoprotein (AFP)-Producing Gastric Cancer, Extragonadal Yolk Sac Tumors
- Trial name
- NCT06427941
- Testing
- BGB-B2033, Tislelizumab, Bevacizumab
- Where
- 51 sites in United States, Brazil and 7 more
- Volunteers
- 630 people
- Sponsor
- BeOne Medicines
Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control
Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease
The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at…
- Trial name
- PPi-DIA (NCT06300788)
- Testing
- PPI and T50 dosing
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Non-Alcoholic Fatty Liver Disease
Fetuin-A, a Promising Serum Biomarker for Diagnosis of Non-Alcoholic Fatty Liver Disease
The work investigate the role of fetuin-A in the diagnosis and assessment of the severity of non-alcoholic fatty liver disease (NAFLD).
- Trial name
- NAFLD (NCT06097039)
- Testing
- abdominal U/S, Fibroscan with Controlled Attenuated Parameter (CAP scan):
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Placenta Accreta
Maternal Serum Alpha-fetoprotein Level May Predict the Presence of Morbid Adherent Placenta
The aim of the study is to compare between alpha-fetoproteine as a biological marker and between ultrasound and Doppler in prediction of morbid adherent placenta.
- Trial name
- NCT04082507
- Testing
- Serum alpha-fetoproteine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- rasha medhat abdul-hady
Gastric Cancer
Study of Camrelizumab (SHR-1210) and Apatinb Based Therapies for Alpha-fetoprotein (AFP)-Producing Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
This is a study of Camrelizumab (SHR-1210) and Apatinb for unresectable Recurrent or metastatic alpha-fetoprotein (AFP)-producing gastric cancer or Gastroesophageal Junction Adenocarcinoma.
- Trial name
- NCT04609176
- Testing
- Camrelizumab plus Apatinib and SOX, Camrelizumab plus Apatinib
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking University
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Hepatoblastoma, Hepatic Hemangioendothelioma
PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants
Although hepatic tumors are uncommon in the perinatal period they are associated with significant morbidity and mortality in affected patients.
- Trial name
- PIVKA-II (NCT03645655)
- Testing
- PIVKA-II
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Shanghai Children's Medical Center
Hepatocellular Carcinoma, Cirrhosis
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment
This study will evaluate the usefulness of plasma proteasome levels as a tumor marker of hepatocellular carcinoma (HCC) by studying their variation following curative treatment of HCC.
- Trial name
- NCT01492127
- Testing
- Blood test
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Periodontitis, Diabetes Mellitus, Type 2
Chemerin, Fetuin-A, IL-34 and IL-13 Levels in Diabetic Periodontitis Patients
The present study aimed to assess the effect of non-surgical periodontal treatment on serum and salivary chemerin, fetuin-A, IL-34 and IL-13 levels in periodontitis with and without diabetes mellitus (DM) type 2.
- Trial name
- NCT06135532
- Testing
- Non-Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Marmara University
Hepatocellular Carcinoma, Liver Cirrhosis
Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)
This prospective multicenter observational study evaluates the performance of a structured hepatocellular carcinoma (HCC) surveillance program in patients at increased risk of developing liver cancer.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hepatitis B, Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- Screening HCC (NCT07764835)
- Volunteers
- 300 people
- Sponsor
- D'Or Institute for Research and Education
Carcinoma, Hepatocellular
A Cross Sectional Study Evaluating the Mean Levels of Alpha Fetoprotein in Patients of Hepatocellular Carcinoma and Its Correlates in Pakistan
This study aims to explore the levels of alpha-fetoprotein (AFP), a protein often elevated in liver cancer, in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT06629857
- Where
- Pakistan
- Volunteers
- 94 people
- Sponsor
- Darul Sehat Hospital
NAFLD
The Effect of Soy Isoflavones on Non-alcoholic Fatty Liver Disease and the Level of FGF-21 and Fetuin A
In this research, the investigators tested the effect of 12-week supplementation with soy isoflavones on non alcoholic fatty liver disease (NAFLD) management and the level of fibroblast growth factor-21 (FGF-21) and fetuin A as…
- Trial name
- NCT06101433
- Testing
- Soy isoflavone
- Where
- Iran
- Volunteers
- 46 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences