Clinical trials: Fertility
Cancers
Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
The purpose of this study is to safely remove ovarian tissue in pre-pubertal pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
- Trial name
- NCT05299710
- Testing
- Laparoscopic surgery
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Erin Rowell
Uterine Cancer
Prognostic Role of molEcular classiFication in Fertility-sparing treAtment of Endometrial canCEr
Endometrial cancer, the most common gynecologic malignancy in high-income countries, is increasing among reproductive-age women.
- Trial name
- PREFACE (NCT06799624)
- Testing
- Observation only
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Testis, Infertility
TNFSF11 Inhibition and Fertility: a Prospective Study
The receptor activator of NF-kB ligand (RANKL) system is considered important for bone homeostasis and comprises three important factors.
- Conditions
- Testis, Infertility, Sperm
- Trial name
- NCT02422108
- Testing
- Denosumab
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Martin Blomberg Jensen
Endometriosis
Influence of Laparoscopic Endometrioma Stripping Surgery on Serum Anti-mullerian Hormone Levels
To compare changes in follicular ovarian reserve in women before and six months after laparoscopic operation: endometrioma stripping surgery.
- Trial name
- NCT02286076
- Where
- 3 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Centre of Serbia
Infertility, Fertility Disorders
Live Birth Rate After Sperm Selection Using ZyMōt Multi (850µL) Device for Intra Uterine Insemination
This single centre interventional pilot randomized control study intends to compare two methods of sperm preparation for couples referred for Intra Uterine Insemination (IUI) procedure.
- Trial name
- FERTINSEM (NCT06144268)
- Testing
- ZyMōt Multi (850µL), Density Gradient Centrifugation
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Primary Infertility, Mental Health Issue
A Pilot RCT: the Impact of a Virtual MBSR Course on Women With Primary Infertility
We plan to perform a pilot study in which women with primary infertility seeking an initial fertility consultation will be randomized into either a standard treatment group or an 8-week virtual Mindfulness-Based Stress Reduction…
- Conditions
- Primary Infertility, Mental Health Issue, Quality of Life
- Trial name
- NCT05903638
- Testing
- Mindfulness-Based Stress Reduction course
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- One Fertility
Fertility Disorders
Effects of Lifestyle Changes on Semen Quality in Healthy Young Men Living in Highly Polluted Areas (FAST)
We planned a randomized controlled trial (RCT) with the main aim to evaluate the effects of lifestyle changes on semen quality in healthy young men living in polluted areas in Italy.
- Trial name
- FAST (NCT04012385)
- Testing
- lifestyle counseling
- Where
- 4 sites in Italy
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria Locale Salerno
Asthma, Infertility, Female
Treatment With the Anti-IgE Monoclonal Antibody Omalizumab in Women With Asthma Undergoing Fertility Treatment. - A Proof of Concept Study.
The investigators have previously confirmed a clinical hunch that women with asthma have difficulties in becoming pregnant. The investigators found increased time to pregnancy (TTP) in women with asthma compared to non-asthmatic…
- Trial name
- PRO_ART (NCT03727971)
- Testing
- Omalizumab Injection, NaCl
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility
Growth Hormone to Improve the Clinical Outcome of Assisted Fertility in Young Patients With Decreased Ovarian Reserve
This study was a prospective randomized controlled trial. Patients aged <35 years with decreased clinical reserve function (AFC<5, Follicle stimulating hormone > 10miu/ml, Anti-mullerian hormone < 1.1μg/L) and receiving IVF/ICSI…
- Trial name
- NCT05585177
- Testing
- Growth hormone
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing University
Polycystic Ovary Syndrome, Miscarriage
The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether metformin may improve pregnancy rates, and decrease miscarriage rates and complications of pregnancy, such as toxemia and gestational diabetes, in women with polycystic ovary…
- Conditions
- Polycystic Ovary Syndrome, Miscarriage, Infertility, Toxemia
- Trial name
- NCT00994812
- Testing
- metformin
- Where
- 5 sites in Finland
- Volunteers
- 326 people
- Sponsor
- University of Oulu
Obesity, Fertility
Dysregulation of FSH in Obesity: Functional and Statistical Analysis
Excess maternal weight, especially obesity, influences almost every aspect of fertility, from conception to problems during pregnancy.
- Trial name
- NCT02478775
- Testing
- Degarelix (GnRH antagonist), recombinant FSH, Cetrorelix
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Liver Fat, Fertility Disorders
Effect of Lifestyle Intervention on Mobilization of Fat Storage and Iron Deposition in Obesity
The goal of this clinical trial is to learn if calorie-restricted balanced diet could uniquely influence various fat storage pools and iron deposition and explore the relationships between fat or iron deposition loss in specific…
- Conditions
- Liver Fat, Fertility Disorders, Life Style, Healthy, Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Trial name
- NCT06441409
- Testing
- Lifestyle intervention
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Infertility, Male, Infertility
Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors
The cause of infertility can be due to a female factor or a male factor. In case of a male factor, it is often due to poor semen quality. However, the cause of poor quality is often unknown.
- Trial name
- SIRIUS (NCT05514223)
- Testing
- Biomaterial collection for observational purpose
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Breast Neoplasm Female, Fertility Preservation
Web-based Oncofertility Support Tool for Reproductive-age Women With Breast Cancer
The aim of this study was to develop electronic systems (e-systems) for oncofertility support, and to examine the comprehensibility, feasibility, usability, and effects on social support and preparation for decision-making.
- Trial name
- NCT05100498
- Testing
- Web-based oncofertility support tool
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mackay Medical College
Acute Leukemia
Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults
Gynecological impact and infertility are major issues for women after allogeneic hematopoietic stem cell transplantation. The aim of the present study is to investigate the prevalence of gynecological complications after…
- Trial name
- GYNEGRAFT (NCT07048730)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
IVF Outcomes
HELIOS: Human Embryo Illumination to Enhance Development
Embryos need a lot of energy to grow, but as women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for embryos to develop normally.
- Trial name
- HELIOS (NCT07311928)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Infertility
Diafert for Embryo Selection and Fertility Improvement
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02586272)
- Testing
- Daifert, Control Group
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Forest Laboratories
Fertility Preservation
Vitrification of Oocytes Matured by CAPA-IVM
It has been reported that the potential of In Vitro matured oocytes might be affected by the vitrification process. In fact, the freezing and thawing procedures routinely used in IVF laboratories, have not yet been adapted to…
- Trial name
- NCT06157619
- Testing
- Oocyte Vitrification /Warming
- Where
- Peru
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centro de Fertilidad y Reproducción Asistida, Peru
Infertility, Female
Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation
The recent innovations in cancer diagnosis and therapy have improved the five-year survival for patients. However, anticancer treatments may impair patient fertility; therefore fertility preservation is recommended before therapy…
- Trial name
- FERTIOVO (NCT06724471)
- Testing
- Human ovarian tissue cryopreservation using thermosoldered or screwed cryovials
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer, Lymphoma
Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma
The purpose of this study is to see how cancer treatment affects sexual and reproductive function. The patient will also be asked to participate in blood draws to see if and how cancer treatment affects the ovaries and the…
- Conditions
- Breast Cancer, Lymphoma, Hodgkin's Lymphoma
- Trial name
- NCT01788839
- Testing
- surveys, Blood draw, Transvaginal ultrasounds
- Where
- 7 sites in United States
- Volunteers
- 475 people
- Sponsor
- Memorial Sloan Kettering Cancer Center