Clinical trials: Fentanyl
Anesthesia, Opioid Use
Opioid-Free Anesthetic for Tonsillectomy
Prospective randomized controlled trial to determine if opioid-free anesthetic for tonsillectomy is non-inferior to standard opioid-containing anesthetic
- Conditions
- Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder
- Trial name
- NCT04528173
- Testing
- Ketorolac, Dexmedetomidine, Morphine
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Anesthesia, Pain
Memory & Conditioning Under Anesthesia
The purpose of this study is to determine the effects of pain on long-term memory and conditioned physiologic responses in the presence and absence of distinct intravenous anesthetics.
- Trial name
- MCA (NCT04062123)
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Obstructive Sleep Apnea, Tonsillitis
Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.
- Trial name
- NCT04230681
- Testing
- Hydromorphone, Fentanyl
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fentanyl Overdose, Fentanyl Poisoning
A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CS-1103 (1,000 mg), given by intravenous (IV) infusion in healthy participants in the presence of a clinically relevant dose of…
- Trial name
- NCT07459166
- Testing
- Naloxone Hydrochloride, Fentanyl, Sterile Saline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Laparoscopic Cholecystectomy
Comparison Between Dexmedetomidine and Fentanyl As an Adjuvant to Bupivacaine in the Paravertebral Nerve Block in Laparoscopic Cholecystectomy for Postoperative Analgesia: Randomized Comparative Clinical Trial.
Laparoscopic cholecystectomy is one of the most common surgeries today, cause it has many advantages over open cholecystectomy. Although these advantages pain remains a big problem after laparoscopic cholecystectomy which causes…
- Trial name
- NCT06752629
- Testing
- Bupivacaine and Dexmedetomidine, Bupivacaine and Fentanyl
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Abscess
Pain Management in ED for Incision and Drainage of Abscess
Patients presenting with painful procedures in the Emergency Department (ED) have been shown to frequently have inadequate pain management.
- Trial name
- NCT01881997
- Testing
- Fentanyl, Normal Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Postoperative Analgesia
Continuous Epidural Fentanyl- Low Dose Bupivacaine Infusion Analgesia for Precious Single Kidney Patient.
Open surgical nephrectomy is associated with sever postoperative pain mandating alternative strong ,renal safety, minimal side effects, and minimal rescue systemic analgesics , continuous Epidural Fentanyl infusion in a dose step…
- Trial name
- NCT03606902
- Testing
- Group f : Epidural catheter insertion, Group F: Continous epidural infusion of bupivacaine plus fentanyl, Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Healthy, Opioid Use
Buprenorphine-Fentanyl Interaction Study
An increase in overdose deaths has been attributed to widespread access to fentanyl and carfentanyl. The study is designed to determine if buprenorphine can change the respiratory depression response to intravenous (IV) fentanyl.
- Trial name
- NCT03747341
- Testing
- Buprenorphine Injectable Solution - Part A, Fentanyl - Part A, Ondansetron - Parts A + B
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Anesthesia
Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
Cystoscopy is a simple, effective and reliable method in current urological practice. Anesthesia may be required in cystoscopy for therapeutic purpose, however it may not be necessary for diagnostic cystoscopy.
- Trial name
- NCT03424356
- Testing
- Rocuronium Bromide, Saline Solution, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy
Study Evaluating Inhaled AeroLEF Delivered in 4 Aerosol Delivery Devices in Healthy Volunteers
This was an open-label, two-phase, crossover, safety, pharmacokinetic (PK), and pharmacodynamic (PD) study in normal, healthy, non-smoking, fasting male and female subjects. The first phase (A.
- Trial name
- LEF-07 (NCT00794209)
- Testing
- i.v fentanyl, AeroLEF
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- YM BioSciences
Full Term Pregnant Patients, Undergoing Lower Segment Caesarian Section
Comparison of Different Doses of Clonidine to Fentanyl as an Adjuvant to Bupivacaine 0.5% for Spinal Anesthesia
The purpose of this study is to evaluate the safety, quality and duration of block with the addition of Clonidine in different doses to 0.5% heavy bupivacaine, and to compare it with addition of Fentanyl to 0.5% heavy bupivacaine…
- Trial name
- NCT01205204
- Testing
- Fentanyl, Clonidine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pravara Institute of Medical Sciences University
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Labor Pain
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: A Sequential Allocation Trial to Determine the Optimum Interval Time Between Boluses of a Fixed Volume of 2.5ml of Bupivacaine 0.25% Plus Fentanyl 8 mcg/ml
Programmed intermittent epidural bolus (PIEB) is a technique of epidural analgesia in which boluses of local anesthetic solutions are injected into the epidural space at a fixed time interval.
- Trial name
- NCT03735771
- Testing
- Bupivacaine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Adequate Anesthesia With Unimpaired Motor Strength
Comparison of Intrathecal Fentanyl or Sufentanil in 1 mg Bupivacaine Spinal Anesthesia for TURP in Elderly Patients
Adequate sensory block for surgical procedure without side effects and immediate mobilization after surgery are desirable anesthetic technique in various surgeries.
- Trial name
- NCT01608334
- Testing
- Fentanyl, Sufentanil
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Headaches
RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches
Background : Headaches are a common presentation for children consulting to the Emergency Department (ED). However, only few studies have evaluated the rapid pain improvement provided by medications in the acute management of…
- Trial name
- NCT02638506
- Testing
- Fentanyl, Salinex
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Vaginal Delivery, Normal Labor
Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
the goal of this randomized control trial is to compare the effect of adding fentanyl v.s dexmedetomidine to bupivacaine in single shot spinal analgesia in achievement of analgesia by decreasing visual analogue scale, onset and…
- Trial name
- SSSA (NCT06823349)
- Testing
- Dexmedetomidine, fentanyl, Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jehan George Sadek
Anesthesia, Psychomotor Status
Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy
This is a prospective cohort study that will analyze psychomotoric recovery using a commercially available driving simulator following sedation for endoscopic procedures in subjects undergoing elective outpatient endoscopic…
- Trial name
- NCT04350424
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Anxiety and Fear
A Comparison Between Dexmedetomidine and Propofol-fentanyl Infusions for Sedation for Colonoscopy Procedures
Background: Different intravenous sedative drugs have been utilized for colonoscopy, with many anesthetists for painless sedation or monitored anesthesia care.
- Trial name
- NCT06148103
- Testing
- Patients who received Dexmedetomodine, patients who received propofol-fentanyl
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zulekha Hospitals
Healthy
A Study to Evaluate the Adherence of 2 Strengths of Newly Manufactured Samples and Aged Samples of a New Formulation (JNJ-35685-AAA-G016 and JNJ-35685-AAA-G021) of Fentanyl Transdermal System Compared With Duragesic Fentanyl Transdermal Patch in Healthy Participants
The purpose of this study is to evaluate the cumulative adhesion percentage for the test products and the reference products for both small and large patches.
- Trial name
- NCT02608320
- Testing
- Duragesic (Fentanyl Transdermal System [TDS] Small Patches), New JNJ-35685-AAA-G016 (Fentanyl TDS -Small Patches), Aged JNJ-35685-AAA-G016 (Fentanyl TDS Small Patches)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Labor Pain
Analgesic Additives to Epidural Bupivacaine in Normal Labor
The aim of the study will be to compare the role of Dexmedetomidine, Nalbuphine and fentanyl as additives to epidural bupivacaine in painless vaginal delivery as regard of effectiveness analgesia and maternal safety.
- Trial name
- NCT05746351
- Testing
- Dexmedetomidine, fentanyl, Nalbuphine
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assiut University