Clinical trials: Female Urinary Incontinence and Pelvic Organ Prolapse
Stress Incontinence Female, Pelvic Organ Prolapse
Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy
This study looks at the best time to place a midurethral sling (MUS), which is a small piece of mesh used to treat stress urinary incontinence (SUI) (leaking urine when you cough, laugh, or exercise).
- Trial name
- NCT07008898
- Testing
- Midurethral sling placed before robotic sacrocolpopexy, Midurethral sling placed after robotic sacrocolpopexy
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Urodynamic Stress Incontinence, Detrusor Overactivity
USI and/or DO in Women With Cystocele Before and After Cystocele Repair
The changes of lower urinary tract function after cystocele repair are important for perioperative consultation and management. Thus, the aim of this retrospective study was to evaluate the prevalence of urodynamic stress…
- Trial name
- NCT04978714
- Testing
- Cystocele repair
- Where
- Taiwan
- Volunteers
- 483 people
- Sponsor
- National Taiwan University Hospital
Urinary Incontinence, Pelvic Organ Prolapse
Promoting Effective Recovery From Labor Urinary Incontinence (PERL)
The purpose of this study is to determine whether pushing during labor that is controlled by the woman results in less birth-related injury and less postpartum urinary incontinence (UI).
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse, Perinatal Laceration, Second Stage Labor
- Trial name
- PERL (NCT00506116)
- Testing
- Videotape, routine care, PME instruction, PME practice and record keeping (in diaries), Non-directed or directed,spontaneous or sustained pushing
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction
Association With Low Compliance Bladder in Women With LUTS
Hypothesis / aims of study The clinical and urodynamic features on the severity of low compliance bladder in neurologically intact women with lower urinary tract symptoms are indeterminate.
- Conditions
- Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT06210477
- Testing
- medical treatment for lower urinary tract symptoms
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Pelvic Organ Prolapse, Stress Urinary Incontinence
Lidocaine for Pessary Check Pain Reduction
The primary objective of this study is to estimate the effect of lidocaine jelly on patient pain at the time of office pessary removal.
- Trial name
- NCT05493735
- Testing
- Lidocaine Hcl 2% Jelly
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
SMAD2, SMAD3
SMAD2, SMAD3 AND TGF-β GENE EXPRESSION IN URGE URINARY INCONTINENCE
Urge urinary incontinence (UUI) is a common health problem. Changes in collagen metabolism in pelvic support organs, such as uterosacral ligaments (USLs), might be responsible for the complex pathophysiology of UUI.
- Conditions
- SMAD2, SMAD3, TGF-β, Pelvic Organ Prolapse
- Trial name
- NCT04525105
- Testing
- SMAD2
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Muğla Sıtkı Koçman University
Stress Urinary Incontinence, Vaginal Prolapse
BELIEVE Trial: Bulking vErsus sLing for Treating Stress Urinary IncontinEnce at the Time of Vaginal prolapsE Repair (BELIEVE)
The goal of this clinical trial is to learn if retropubic midurethral sling (RP-MUS) or bulkamide injection (PAHG) at the time of pelvic organ prolapse repair is better from the patient's perspective.
- Trial name
- BELIEVE (NCT06754046)
- Testing
- RP-MUS, PAHG
- Where
- United States
- Volunteers
- 476 people
- Sponsor
- University Hospitals Cleveland Medical Center
Prolapse, Urinary Incontinence
Long-term Effectiveness of Abdominal Sacrocolpopexy for the Treatment of Pelvic Organ Prolapse
The Colpopexy and Urinary Reduction Effort (CARE) trial is a research study designed to evaluate whether the addition of a second surgical procedure in addition to a procedure for female pelvic organ prolapse (POP) affects the…
- Trial name
- E-CARE (NCT00099372)
- Where
- 8 sites in United States
- Volunteers
- 215 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Pelvic Organ Prolapse, Urinary Incontinence
Vaginal Estradiol Use in Pessary Care
The primary outcome of this study compare the rate of pessary discontinuation at 6 months post-pessary fitting in women using vaginal estradiol versus those not using vaginal estradiol.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pessary Ulcer of Vagina, Vaginal Atrophy
- Trial name
- NCT05458375
- Testing
- Estradiol vaginal cream
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Uterine Prolapse, Urine Incontinence
The Assessment of Fibrin Clot Phenotype and Thrombin Generation in Women After Urogynecological Surgeries.
Determination of fibrin clot properties along with thrombin generation in women after urigynecological surgery.
- Trial name
- NCT07295782
- Testing
- determination of fibrin clot properties
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Catheter-Associated Urinary Tract Infection
Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
The specific aim of this randomized double-blind placebo-controlled trial is to evaluate the efficacy of administration of nitrofurantoin prophylaxis after catheter discontinuation for the prevention of catheter-associated…
- Trial name
- NAUTICA (NCT03287089)
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Wake Forest University Health Sciences
Pelvic Organ Prolapse
The Development of De-novo Stress Urinary Incontinence After Stage II-III Pelvic Organ Prolapse Surgery
Surgery for Stage II-III Pelvic organ prolapse
- Trial name
- NCT03221725
- Testing
- sacrospinous ligament fixation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cystocele, Pelvic Organ Prolapse
Safety and Efficacy of Non-ablative Er:YAG Laser Therapy for the Treatment of Pelvic Organ Prolapse and Coexisting Stress Urinary Incontinence: A Retrospective Case Series.
The objective of the study is to retrospectively collect the data on patients who underwent pelvic organ prolapse treatment using a non-ablative Er:YAG laser with SMOOTH mode and to conduct an objective evaluation of safety and…
- Conditions
- Cystocele, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- NCT04417413
- Testing
- Fotona ProlapLase
- Where
- Serbia
- Volunteers
- 41 people
- Sponsor
- Aleksandra Novakov Mikic
Lower Urinary Tract Symptom in Severe Cystocele Women
Prevalence Rates of USI, BO, DO and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele
Prevalence rates of urodynamic stress incontinence (USI), bladder oversensitivity (BO) /detrusor overactivity (DO) or both and their related clinical and urodynamic findings in women with ≥ pelvic organ prolapse quantification…
- Trial name
- NCT03613350
- Testing
- Pad test
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Pelvic Organ Prolapse, Stress Urinary Incontinence
Outcomes of Pelvic Surgery With and Without Anti-incontinence Procedure in Occult Stress Urinary Incontinence Patients
1. To evaluate whether a standardized tension-free vaginal tape-obturator(TVT-O) procedure, when added to a planned improved reconstruction pelvic surgery, improves the rate of urinary stress continence in subjects with occult…
- Conditions
- Pelvic Organ Prolapse, Stress Urinary Incontinence, Other Specified Urinary Incontinence
- Trial name
- PTOS (NCT02193607)
- Testing
- TVT-O, Improved reconstruction pelvic surgery
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Peking Union Medical College Hospital
Urinary Incontinence, Anal Incontinence
Pelvic Floor Muscle Training During Pregnancy
The project seeks to investigate effectiveness of PFMT during pregnancy.
- Conditions
- Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Sexual Dysfunction
- Trial name
- NCT07104292
- Testing
- PFMT, Standard care
- Where
- Denmark
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Pelvic Organ Prolapse, Urinary Incontinence
Pelvic Floor Muscle Training Programme in Pregnant Nepalese Women- a Feasibility Study
To our knowledge, no studies in Nepal have reported the feasibility of performing the pelvic floor muscle training in Nepalese women.
- Trial name
- PFMT (NCT03349736)
- Testing
- Pelvic Floor Muscle Training
- Where
- Nepal
- Volunteers
- 253 people
- Sponsor
- Kathmandu University School of Medical Sciences
Pelvic Floor Dysfunction, Postpartum Care
Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction
The main goal of this study to compare self-training postpartum and training with a specialist support (physiotherapist and physical medicine and rehabilitation doctor) effect on pelvic floor dysfunction prevention and treatment…
- Conditions
- Pelvic Floor Dysfunction, Postpartum Care, Postpartum Comfort, Female Urinary Incontinence and Pelvic Organ Prolapse
- Trial name
- DDDPREV (NCT07426770)
- Testing
- Rehabilitation postpartum, Self-training
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Stress Urinary Incontinence, Pelvic Organ Prolapse
Evaluating the Necessity of TOT Implantation in Women With Pelvic Organ Prolapse and Occult Stress Urinary Incontinence
Nowadays the clinical significance of an occult stress urinary incontinence and its optimal treatment is not known.Regarding treatment, there are 2 main approaches : either the systematic preventive treatment of the occult stress…
- Trial name
- ATHENA (NCT01095692)
- Testing
- Pelvic Organ Prolapse and Suburethral TOT implantation, Pelvic Organ Prolapse intervention
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pelvic Organ Prolapse
The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study
Women will be invited to participate in E-OPTIMAL at their last clinical follow-up visit for OPTIMAL (at 24 months post surgery).
- Trial name
- E-OPTIMAL (NCT01166373)
- Testing
- Enrollment video, SSLF, ULS
- Where
- 7 sites in United States
- Volunteers
- 285 people
- Sponsor
- NICHD Pelvic Floor Disorders Network