Clinical trials: Fecal Microbiota Transplantation
Irritable Bowel Syndrome
Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Many patients with irritable bowel syndrome (IBS) do not experience adequate symptom relief with current treatments. The pathophysiology of IBS is diverse, controversial and not completely understood.
- Trial name
- NCT04691544
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Irritable Bowel Syndrome
Fecal Microbiota Transplantation to Relieve Symptoms of Irritable Bowel Syndrome Without Constipation
Irritable bowel syndrome (IBS) is a complex multifactorial functional disorder, whose pathophysiology is largely associated to an impairment of the intestinal microbiota composition, namely dysbiosis.
- Trial name
- TRAMIR (NCT05803980)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Clostridioides Difficile Infection, Drug Resistance, Bacterial
Effect of Oral Microbiota on MDRO Decolonization
Randomized, placebo-controlled trial to evaluate the safety and efficacy of oral intestinal microbiota capsules for decolonizing multidrug-resistant organisms (MDROs) and Clostridioides difficile in patients requiring prolonged…
- Conditions
- Clostridioides Difficile Infection, Drug Resistance, Bacterial, Gastrointestinal Microbiome, Multidrug-resistant Colonization
- Trial name
- NCT07496502
- Testing
- Microbiota capsule
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Autism Spectrum Disorder, Gastro-Intestinal Disorder
Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating patients with Autism-spectrum disorder with Gastrointestinal disorders (constipation, diarrhea, and/or abdominal pain).
- Conditions
- Autism Spectrum Disorder, Gastro-Intestinal Disorder, Constipation, Diarrhea
- Trial name
- NCT06503978
- Testing
- MTP-101P, Vancomycin, Miralax
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gut-Brain-Axis Therapeutics Inc.
Eating Disorders Symptoms
Effects of Fecal Microbiota Transplantation
The intestinal microbiota plays an essential role in digestion and, through the gut-brain axis, in the regulation of weight gain and eating behavior.
- Trial name
- Transmic-TCA (NCT07196189)
- Testing
- Patients, healthy volunteer
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Malnutrition, Gastroenterostomy
Washed Microbiota Transplantation for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract
This is a prospective, randomized, multicenter study to evaluate WMT in improving nutritional status in malnourished patients who underwent nonphysiological reconstruction of the upper gastrointestinal tract.
- Trial name
- NCT05439135
- Testing
- washed microbiota transplantation
- Where
- China
- Volunteers
- 62 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Irritable Bowel Syndrome, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Irritable Bowel Syndrome Associated Food Intolerance
Previous studies have shown that stool transplantation (FMT) have positive effect in symptoms for some patients with irritable bowel syndrome (IBS).
- Trial name
- FinFMT-IBS (NCT05361785)
- Testing
- FMT
- Where
- Finland
- Volunteers
- 45 people
- Sponsor
- Helsinki University Central Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Safety and Efficacy of Capsule FMT in Treatment-naïve Patients With Newly Diagnosed Chronic Inflammatory Diseases
PURPOSE: The main purpose is to explore clinical efficacy and safety associated with capsule FMT (cFMT) performed in newly diagnosed, untreated patients with rheumatic and gastrointestinal chronic inflammatory diseases (CIDs).
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Crohn Disease
- Trial name
- FRONT (NCT04924270)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Renal Cell Carcinoma
Preventing Toxicity in Renal Cancer Patients Treated With Immunotherapy Using Fecal Microbiota Transplantation
Cancer immunotherapy has been largely adopted in oncology patient management in the last decade. The deep and long responses to immunotherapy have accelerated the approval of these drugs across multiple disease sites.
- Trial name
- PERFORM (NCT04163289)
- Testing
- Fecal Microbiota Transplantation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Amyotrophic Lateral Sclerosis
Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients
Given the role of adaptive immunity in ALS, the pathogenicity of some clostridial strains on motorneurons, the putative role of cyanobacteria in ALS development, and the increasing interest for microbiota in neurodegenerative…
- Trial name
- FETR-ALS (NCT03766321)
- Testing
- Fecal microbiota transplantation
- Where
- 5 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Hematopoietic and Lymphoid Cell Neoplasm
Fecal Microbiota Transplantation for Steroid Resistant/Dependent Acute GI GVHD
The purpose of this study is to evaluate the efficacy and safety of fecal microbiome transplantation in patients with steroid resistant/dependent acute gastrointestinal graft-versus-host disease (GVHD).
- Trial name
- FEMITGIGVHD (NCT03812705)
- Testing
- fecal microbiome transplantation
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Liver Cirrhosis
Fecal Microbiota Transplantation in Decompensated Cirrhosis
Cirrhosis of the liver is the culmination point of long-standing chronic liver disease hallmarked by the cardinal features of liver fibrosis and portal hypertension.
- Trial name
- NCT04842539
- Testing
- Fecal Microbiota Transplantation, Standard of care
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Inflammatory Bowel Diseases, Ulcerative Colitis
Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis
The primary aims of this phase I/II, randomized, placebo controlled study are the assessment of safety and tolerability of universal donor FMT compared to placebo in pediatric and young adult subjects (ages 5 years through 30…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT02330653
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stacy A. Kahn
Clostridium Difficile Infection
Treatment of C. Difficile Infection With Fecal Microbiota Transplantation (FMT)
The purpose of this study is to treat children with severe, moderate, resistant or relapsing C. difficile infection and to determine the changes in the intestinal microbiome (all of the bacteria living in the intestines) in…
- Trial name
- NCT01842347
- Testing
- Fecal microbiota
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Ulcerative Colitis
Impact of Fecal Microbiota Transplantation in Ulcerative Colitis
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. UC pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota (called dysbiosis) in…
- Trial name
- REBALANCE-UC (NCT03483246)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
Application of Esketamine in Anesthesia of Autism Children
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia.
- Trial name
- NCT05960942
- Testing
- propofol combined with esketamine, propofol-sufentanil
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Diversion Colitis
Autologous Fecal Microbiota Transplantation for Diversion Colitis
Diversion colitis (DC) is a common inflammatory complication in patients with temporary ileostomy after rectal cancer surgery, and no standardized medical treatment exists.
- Trial name
- NCT07674186
- Testing
- Autologous Fecal Microbiota Transplantation (auto-FMT), saline irrigation
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Yongjian Liao
Autism Spectrum Disorder, Gastro-Intestinal Disorder
MTT for Children With ASD Who Have Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating children with Autism Spectrum Disorder (ASD) and gastrointestinal problems (primarily constipation and/or diarrhea).
- Conditions
- Autism Spectrum Disorder, Gastro-Intestinal Disorder, Constipation, Diarrhea
- Trial name
- NCT04182633
- Testing
- vancomycin, Miralax, intestinal microbiota
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Arizona State University
Ulcerative Colitis, Inflammatory Bowel Disease
Faecal Microbiota Transplantation in Ulcerative Colitis
The purpose of this study is to determine whether fecal microbiota transplantation (FMT) is safe and efficacious in the treatment of chronic active ulcerative colitis (UC) by conducting a randomised controlled trial
- Trial name
- FOCUS (NCT01896635)
- Testing
- FMT infusions
- Where
- 3 sites in Australia
- Volunteers
- 81 people
- Sponsor
- The University of New South Wales
Irritable Bowel Syndrome
FMT in the Treatment of IBS
52 adult IBS patients were recruited. 50% were given a fecal microbiota transplantation in colonoscopy and 50% were given an FMT made of their own feces as placebo. follow up time was 1 year after FMT.
- Trial name
- FMT-IBS (NCT03561519)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- Finland
- Volunteers
- 52 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care