Clinical trials: Feasibility Pilot Study
Recurrent Childhood Acute Lymphoblastic Leukemia
Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)
This Phase II trial is studying how well giving epratuzumab together with an established chemotherapy platform works in treating young patients with relapsed acute lymphoblastic leukemia.
- Trial name
- NCT00098839
- Testing
- L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone
- Where
- 46 sites in United States, Australia and 2 more
- Volunteers
- 134 people
- Sponsor
- Children's Oncology Group
Onychomycosis of Toenail
Light Therapy for Onychomycosis Study
This is a pilot prospective study designed to capture information about the safety and effectiveness of the ToeFX Therapy Light.
- Trial name
- NCT05139888
- Testing
- Single wavelength light (red) only, Dual wavelength light (red/blue)
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ToeFX Inc.
Attention Deficit Hyperactivity Disorder
Pilot Feasibility Study of Neurofeedback for Attention Deficit Hyperactivity Disorder (ADHD)
Neurofeedback is increasingly advocated for treatment of ADHD despite a thin evidence base. The numerous open and partially controlled studies suffer serious design flaws.
- Trial name
- NCT00886483
- Testing
- Active Neurofeedback
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- L. Eugene Arnold
Cancer
Virtual Reality to Promote Relaxation Prior to Simulation
The purpose of this study is to assess the feasibility of a pre-simulation virtual reality (VR) platform designed to promote relaxation for cancer patients planned for radiation therapy (RT).
- Trial name
- NCT06318338
- Testing
- Virtual Reality Program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Patient Safety, Manipulation, Spinal
(MIST1)-Part 1: Assessment & Feasibility of Post-Symptoms Evaluation
To increase patient safety culture in spinal manipulation therapy (SMT) this study will assess the ability to implement an active surveillance reporting system for a chiropractic teaching clinic and determining preliminary…
- Trial name
- MIST1 (NCT03412097)
- Testing
- active surveillance
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Parker University
Prostate Cancer
A Pilot Study of the Feasibility of Chronic Cavernous Nerve Stimulation to Promote Regeneration and Erectile Function
The goal of this study is to evaluate electrical stimulation of nerves responsible for erectile function after surgery to remove the prostate (prostatectomy).
- Trial name
- NCT02006927
- Testing
- Nerve Stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Kenneth M Peters, MD
Hemophilia
Patient Reported Outcomes Burdens and Experiences - Phase 2
The Patient Reported Outcomes, Burdens, and Experiences (PROBE) Study aims to develop a new global tool to enhance the direct patient-voice in health care decision-making.
- Trial name
- PROBE (NCT02439710)
- Testing
- Quality of life measure (survey)
- Where
- Canada
- Volunteers
- 656 people
- Sponsor
- McMaster University
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Reduction to Improve Mobility Long-Term Care
Medication side effects and interactions between medications are very common in older adults and are related to negative health outcomes, including mobility.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT03202264
- Testing
- TAPER
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
HIV/AIDS, PrEP
Pre-Exposure Prophylaxis in the Emergency Department
Despite an increasing armamentarium of behavioral and biomedical HIV prevention methods, since 2010 rates of new infection have remained around 40,000 annually.
- Trial name
- PrEPPED (NCT04429971)
- Testing
- PrEP screening program, PrEP starter pack
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Invasive Candidiasis
Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067)
This is a pilot feasibility study that investigates antifungal therapy with caspofungin in patients at high-risk for developing invasive candidiasis in a critical care setting.
- Trial name
- NCT01045798
- Testing
- Caspofungin acetate
- Volunteers
- 15 people
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Fistula
Teduglutide for Enterocutaneous Fistula (ECF)
The purpose of this study is to determine whether Teduglutide is safe and feasible to be given for the treatment of enterocutaneous fistula (ECF).
- Trial name
- NCT02889393
- Testing
- Teduglutide, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Daniel Dante Yeh
Ductal Breast Cancer
Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast Cancer
The purpose of this study is to determine the feasibility of partial breast irradiation in participants with early invasive or non-invasive breast cancer.
- Trial name
- NCT00694577
- Testing
- Partial Breast Irradiation using 32 Gy / 8 fractions, Partial Breast Irradiation using 36 Gy / 9 fractions, Partial Breast Irradiation using 40 Gy /10 fractions
- Where
- 4 sites in United States
- Volunteers
- 324 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Severe
Inpatient Single Dose Interventions for Alcohol Use Disorder
Every year, alcohol use disorder (AUD) generates millions of emergency department (ED) visits and hospital admissions, costing the U.S. health sector over $90 billion.
- Trial name
- NCT04562779
- Testing
- Naltrexone 380 MG, Ketamine Hydrochloride, Enhanced linkage
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Denver Health and Hospital Authority
Malocclusion
OrthoPulse™ and Its Effect on the Rate of Orthodontic Tooth Alignment: A Pilot Feasibility Study
The aim of this study is to determine the effect of OrthoPulse™, an intra-oral LED (Light Emitting Diode) photobiomodulation device, on the rate of anterior orthodontic alignment.
- Trial name
- NCT02267837
- Testing
- OrthoPulse™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Biolux Research Holdings, Inc.
First Trimester Abortion, Virtual Reality
Virtual Reality Experience in First Trimester D&C
Virtual reality (VR) has been used in health care settings to decrease anxiety and pain. This project is a feasibility study to evaluate whether virtual reality can be used in the setting of a first trimester pregnancy…
- Trial name
- NCT03533036
- Testing
- applied VR headset
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Carcinoma of the Anal Canal
Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma
This research study is a Pilot Study. Pilot studies are conducted to see if it is practical to do this type of research ona larger scale in the future.
- Trial name
- NCT01858025
- Testing
- Pencil Beam scanning Radiation, 5-fluorouracil, Mitomycin-C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Depression, Anxiety
Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety
This study will examine the feasibility and efficacy of a personalized psychotherapy treatment for people with depression and co-occurring anxiety.
- Trial name
- NCT00930293
- Testing
- Interpersonal Psychotherapy for Depression with Panic and Anxiety Symptoms (IPT-PS), Brief Supportive Psychotherapy (BSP), Citalopram hydrobromide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Adolescent Behavior, Emergency Department
Emergency Department Healthcare Education Assessment and Response for Teen Relationships: A Pilot Feasibility Study
This is a single-site, randomized, controlled trial. Investigators will evaluate feasibility of the Emergency Department Healthcare Education Assessment and Response for Teen Relationships (ED-HEART) intervention among…
- Conditions
- Adolescent Behavior, Emergency Department, Abuse Physical, Abuse Mental
- Trial name
- ED-HEART (NCT05194202)
- Testing
- ED-HEART
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
End Stage Renal Disease, Coronary Artery Disease
Coronary Artery Disease Screening in Kidney Transplant Candidates
Kidney transplant candidates are at very high risk for coronary artery disease (CAD). The optimal strategy to monitor and maintain the cardiac fitness of patients awaiting kidney transplantation is unknown.
- Trial name
- CADScreening (NCT02082483)
- Testing
- Selective Screening
- Where
- 6 sites in Canada
- Volunteers
- 144 people
- Sponsor
- University of British Columbia
School Board Health Centers
Feasibility Study on the Model School Pediatric Health Initiative Pilot Project
This is a prospective cross sectional study to assess the feasibility of a school based health centre (SBHC) at Sprucecourt Public School, an inner-city elementary school in Toronto.
- Trial name
- NCT01676532
- Testing
- Students attending SBHC
- Where
- Canada
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children