Clinical trials: Fear Extinction
Anxiety Disorders
Transcranial Direct Current Stimulation and Fear Extinction
Psychiatric disorders characterized by pathological fear and anxiety are common and often disabling. Despite their limitations, exposure therapies are among the most efficacious treatments for these disorders.
- Trial name
- NCT03907917
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Thomas Adams
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Anxiety Disorder of Childhood
A Pilot Study of Fear Extinction Learning in Anxious Youth
The goal of this proposed study is to identify a potential biobehavioral marker of CBT outcome in the most common child and adolescent anxiety disorders, including separation anxiety disorder (SAD), social phobia (SoP), and…
- Trial name
- NCT03032926
- Testing
- Open Trial
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pediatric Anxiety Disorders
Fear Conditioning, Extinction and Its Recall in Anxious Youth
The proposed research aims to isolate brain-based information-processing mechanisms implicated in perturbed fear learning and extinction characteristic of pediatric anxiety.
- Trial name
- FCPA (NCT02631785)
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fear, Anxiety
Social Support and Reduced Fear Acquisition
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the…
- Trial name
- NCT04564976
- Testing
- Social support image
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stress Related Disorder, Anxiety
Modulation of Fear Extinction Processes Using Transcranial Electrical Stimulation
The aim of this study is to examine the effects of transcranial electrical stimulation on processes associated with fear extinction in healthy humans.
- Trial name
- NCT02723188
- Testing
- DC stimulation (1.5 milliampere, 20 minutes), AC stimulation (1.5 milliampere,1.5 Hertz frequency)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
PTSD
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to…
- Trial name
- NCT05368987
- Testing
- Transcranial magnetic stimulation (TMS), Fear Conditioning and Extinction Paradigm
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
PTSD
Effects of Methylphenidate (Ritalin®) on the Neural Basis of Anxiety
In the present study, investigator will investigate the effects of methylphenidate (40 mg) on mPFC activity in healthy male volunteers during fear extinction using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT02021214
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Post-traumatic Stress Disorder
Effects of Treatment of PTSD on Reduced Recall for Fear Extinction
This preliminary study will examine the differential effects of rTMS on the recall of extinction of conditioned fear in patients suffering from PTSD (post-traumatic stress disorder ) compared with subjects without PTSD but with…
- Trial name
- NCT01228253
- Testing
- rTMS: repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy
Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction
Serotonin and oxytocin play a role in fear conditioning and fear extinction learning, psychological processes that are critically involved in psychiatric disorders such as posttraumatic stress disorder (PTSD).
- Trial name
- MFE (NCT03527316)
- Testing
- MDMA
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Adolescence
Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear.
- Trial name
- BRAINS (NCT06297278)
- Testing
- Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Healthy Participants
Cannabinoid Control of Fear Extinction Neural Circuits in Humans
The goal of the current proposal is to investigate the effects of a cannabinoid drug on the memory of extinguished fear in humans and the brain circuitry important for the recall of extinction learning.
- Trial name
- NCT02472847
- Testing
- Dronabinol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Anorexia Nervosa
Estradiol and Fear Extinction in Anorexia Nervosa (AN)
The purpose of this study is to determine whether estrogen may help reduce fear of high calorie-density foods in weight-restored women with Anorexia Nervosa (AN).
- Trial name
- NCT02792153
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Specific Phobia
Enhancing Exposure Therapy for Snake and Spider Phobias
This study tests whether exposure therapy for fear of snakes or spiders is enhanced by the addition of a brief fear retrieval trial prior to treatment, and the use of compound extinction during treatment.
- Trial name
- Snake/Spider (NCT02160470)
- Testing
- Exposure Therapy with Retrieval, Exposure Therapy with Compound Extinction, Exposure Therapy with Retrieval and Compound Extinction
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
PTSD
The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without…
- Trial name
- NCT06144203
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa