Clinical trials: Fatigue in Multiple Sclerosis, open to volunteers
Multiple Sclerosis
Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple Sclerosis
This is a double-blind, parallel, randomized, sham-controlled pilot study evaluating the safety, feasibility, and efficacy of Gamma Sensory Stimulation (GSS) delivered via a Virtual Reality (VR) headset in individuals with…
- Trial name
- VR-GSS (NCT07310862)
- Testing
- Virtual Reality Gamma Sensory Stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clarity Health Technologies, Inc
Multiple Sclerosis, Pilates Exercise
The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis
Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.
- Conditions
- Multiple Sclerosis, Pilates Exercise, Walking, Balance
- Trial name
- MS (NCT07504120)
- Testing
- Pilates
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois at Chicago
Multiple Sclerosis, Heat Tolerance
Cooling During Inpatient Rehabilitation in Persons With MS
The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Heat Tolerance, Fatigue Symptom
- Trial name
- CoolEx (NCT07852156)
- Testing
- Wearing a cooling vest during intensive, active training sessions, Control
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Klinik Valens
Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS)
Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis.
The goal of this clinical trial is to learn if an online wellness program can lower fatigue and improve mood and quality of life in people with progressive multiple sclerosis who are 45 to 70 years old and are experiencing…
- Trial name
- DEW (NCT07831928)
- Testing
- Online wellness course and online exercise platform, Usual Care Group
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Iowa
Multiple Sclerosis
Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy.
Multiple Sclerosis (MS) is a chronic neurological disease impacting 2.8 million individuals globally, with fatigue being its most debilitating symptom, reported by 75% of patients.
- Trial name
- NIBS_MSf (NCT07842302)
- Testing
- TMS, tDCS
- Volunteers
- 80 people
- Sponsor
- Universitat Oberta de Catalunya
Multiple Sclerosis, Sarcopenia
Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and…
- Conditions
- Multiple Sclerosis, Sarcopenia, Dynapenia
- Trial name
- MS-Sarcopenia (NCT07842731)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Multiple Sclerosis, Relapsing-Remitting, Fatigue
Fatigue Alleviation Through Neuromodulating Therapy in Multiple Sclerosis
The goal of this clinical trial is to learn if repetitive Transcranial Magnetic Stimulation (rTMS) of the left premotor cortex can lessen fatigue in patients with Multiple Sclerosis, and if this is a feasible intervention.
- Trial name
- FANTiMS (NCT06569550)
- Testing
- Real Repetitive Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Multiple Sclerosis, Fatigue
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
CAFE-MS will assess the effectiveness of two online programs for fatigue in multiple sclerosis (MS). Although they differ, both of these online programs contain information about MS and fatigue intended to help people with MS…
- Trial name
- CAFE-MS (NCT06441617)
- Testing
- Online Program for Fatigue
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Accelerated Cure Project for Multiple Sclerosis
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Multiple Sclerosis
Relationship Between Single- and Dual-Task Obstacle Crossing Performance and Fatigue and Disability in Multiple Sclerosis
This cross-sectional observational study aims to investigate the relationship between obstacle crossing performance under single-task and dual-task conditions and the levels of fatigue and disability in individuals with…
- Trial name
- NCT07736482
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Afyonkarahisar Health Sciences University
Multiple Sclerosis, Gait Disorders, Neurologic
"Balance, Gait, and Motion Analysis in Multiple Sclerosis"
The goal of this observational cross-sectional study is to investigate the relationship between functional measures of balance and gait and objective kinetic and kinematic parameters in people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Postural Balance, Motion Analysis
- Trial name
- MS-BALGAIT (NCT07630311)
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University of Patras
Multiple Sclerosis
Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study
The goal of this clinical trial is to learn if a comprehensive rehabilitation programme can improve physical function, reduce fatigue, and raise quality of life in adults aged 18-65 with multiple sclerosis (MS).
- Trial name
- RECONNECT-MS (NCT07666958)
- Testing
- Individual Physiotherapy, Group Movement Awareness, Group Psychotherapy
- Where
- Czechia
- Volunteers
- 45 people
- Sponsor
- Charles University, Czech Republic
Multiple Sclerosis, Multiple Sclerosis Fatigue
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness.
- Trial name
- SOLARIMS (NCT06170970)
- Testing
- Solriamfetol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Fibromyalgia, Chronic Fatigue Syndrome
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03759522
- Testing
- DPA-714 PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS).
- Trial name
- HEAL-MS (NCT07589062)
- Testing
- Multi-Domain Lifestyle Intervention
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- New York University Abu Dhabi
Multiple Sclerosis
Effectiveness of Home-Based Exercise and Brain Stimulation for Reducing Fatigue in Patients With Multiple Sclerosis
This randomized, double-blind, parallel-group clinical trial aims to assess the effectiveness of a combined intervention consisting of a home-based therapeutic exercise program and transcranial direct current stimulation (tDCS)…
- Trial name
- NCT07567989
- Testing
- Home-Based Therapeutic Exercise Program, Transcranial Direct Current Stimulation
- Where
- 3 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Jacobo Formigo
Hypogammaglobulinemia, Multiple Sclerosis
Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?
The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration <7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and…
- Conditions
- Hypogammaglobulinemia, Multiple Sclerosis, Fatigue
- Trial name
- FatIgG (NCT05357781)
- Testing
- Laboratory test
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis, Depression - Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
Canada has one of the highest rates of multiple sclerosis (MS). MS patients experience disabling motor, visual, and sensory symptoms, and a high risk of comorbid major depressive disorder (MDD) and severe fatigue.
- Conditions
- Multiple Sclerosis, Depression - Major Depressive Disorder, Fatigue
- Trial name
- NCT07562074
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Multiple Sclerosis
Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS).
- Trial name
- CerebellertDCS (NCT07555379)
- Testing
- Bilateral Cerebellar Transcranial Direct Current Stimulation (ctDCS)
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
Multiple Sclerosis
Fatigue and Mental Well-Being in MS Patients(Multiple Sclerosis)
This study will be conducted to evaluate the effects of Quran recital on fatigue and mental well-being in patients with multiple sclerosis. Hypotheses: 1. Quran recital reduces fatigue in MS patients. 2.
- Trial name
- MS (NCT07544303)
- Testing
- Quran recital
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Artvin Coruh University