Clinical trials: Fatigue
Apnea, Sleep, Chronic Fatigue Syndrome
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans.
- Trial name
- NCT00252629
- Testing
- Nasal CPAP treatment during sleep
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- US Department of Veterans Affairs
Chronic Fatigue Syndrome
Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process
The purpose of this study is to test the effects of a videotelephone-delivered patient-partner dual-focused cognitive behavioral stress management intervention on chronic fatigue syndrome (CFS) symptoms and related psychosocial…
- Trial name
- NCT01650636
- Testing
- Patient-Partner Videotelephone-delivered Health Information (PP-T-HI), Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Miami
Cancer
Methylphenidate for Cancer-Related Fatigue
The overall aim of this pilot study is to conduct a combined N-of-1 trial (N-1-T) of MPH (methylphenidate) for amelioration of fatigue in children with cancer, and to evaluate the N-1-T design both for individual clinical…
- Trial name
- NCT01164956
- Testing
- methylphenidate
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Dana-Farber Cancer Institute
Advanced Cancers
The Effects of Thalidomide on Symptom Clusters
The goal of this clinical research study is to learn if thalidomide can improve symptoms such as pain, fatigue,anxiety, poor appetite, depression, and sleep problems in patients with advanced cancer.
- Trial name
- NCT00379353
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Glioma
Nuvigil or Placebo in Newly Diagnosed Malignant Glioma
The purpose of this study is to determine if Nuvigil® improves fatigue experienced by people receiving external beam radiation therapy for the treatment of malignant gliomas.
- Trial name
- NCT01400958
- Testing
- Nuvigil®
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Sarcoidosis, Fatigue
SPARC Smartphone Application for the Management of Sarcoidosis-Associated Fatigue
Fatigue is a pervasive and disabling symptom in sarcoidosis with limited treatment options. There is a significant association between heightened stress and sarcoidosis-associated fatigue.
- Trial name
- SPARC (NCT05230693)
- Testing
- Sarcoidosis Patient Assessment and Resource Companion App, Enhanced Standard Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Non-small Cell Lung Cancer, Pancreatic Cancer
Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Study to evaluate the efficacy, safety and tolerability of ponsegromab compared to placebo in patients with cancer, cachexia, and elevated GDF 15.
- Conditions
- Non-small Cell Lung Cancer, Pancreatic Cancer, Colorectal Cancer, Loss of Appetite
- Trial name
- PROACC-1 (NCT05546476)
- Testing
- ponsegromab
- Where
- 78 sites in United States, Australia and 9 more
- Volunteers
- 187 people
- Sponsor
- Pfizer
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
End Stage Kidney Disease (ESRD), Hemodialysis
Hand Reflexology for Fatigue and Anxiety in Hemodialysis Patients
This randomized controlled trial evaluates the efficacy of hand reflexology massage (HRM) in reducing fatigue and anxiety among adult patients receiving maintenance hemodialysis.
- Conditions
- End Stage Kidney Disease (ESRD), Hemodialysis, Anxiety, Fatigue
- Trial name
- NCT07253831
- Testing
- Hand Reflexology Massage, Standard
- Where
- Iraq
- Volunteers
- 70 people
- Sponsor
- Kufa University
Menopause
Effect of Nuvigil on Fatigue
The purpose of this study is to determine if armodafinil improves quality of life and is an effective treatment of fatigue in symptomatic perimenopausal and postmenopausal women.
- Trial name
- NCT01460628
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fatigue, Unspecified Adult Solid Tumor, Protocol Specific
Exercise in Lessening Fatigue Caused by Cancer in Patients Undergoing Chemotherapy
RATIONALE: Physical activity may help lessen fatigue caused by cancer in patients receiving chemotherapy. It is not yet known whether a home-based walking and resistance-band exercise program is effective in lessening fatigue.
- Trial name
- EXCAP (NCT00924651)
- Testing
- exercise
- Where
- United States
- Volunteers
- 693 people
- Sponsor
- Gary Morrow
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cancer
The Effect of a Mediterranean Diet Intervention on Cancer-related Fatigue and Mitochondrial Function During Chemotherapy
This study will assess the feasibility of delivering an 8-week Mediterranean Diet intervention as well as the intervention's preliminary efficacy on cancer-related fatigue among patients undergoing chemotherapy, compared to usual…
- Trial name
- DANICA (NCT04534738)
- Testing
- Mediterranean Diet
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Breast Cancer, Invasive Breast Carcinoma
Adaptive Training Exercise Programs for Improving Cardiorespiratory Fitness After Breast Cancer Treatment, The ACTIVATE Trial
This clinical trial studies the feasibility of implementing various adaptive training exercise programs to improve cardiorespiratory fitness in patients after receiving breast cancer treatment.
- Trial name
- ACTIVATE (NCT04667481)
- Testing
- Aerobic Exercise Intervention, Resistance Exercise Intervention, Exercise Intervention: Digital copies and outline of sessions
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Washington
Chronic Fatigue Syndrome, Orthostatic Hypotension
Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
A subset of patients suffering from chronic fatigue syndrome exhibit symptoms of neurally mediated hypotension. While the underlying pathophysiology of chronic fatigue syndrome is not precisely understood, a dysfunction of the…
- Conditions
- Chronic Fatigue Syndrome, Orthostatic Hypotension, Neurally Mediated Hypotension, Neurogenic Orthostatic Hypotension
- Trial name
- CFS201 (NCT00977171)
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Chelsea Therapeutics
Ulcerative Colitis, Crohn's Disease
Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate
Iron deficiency anaemia is common in inflammatory bowel disease (IBD), affecting at least 20% patients at any one time. Hepcidin, a recently described anti-microbial peptide synthesized by the liver, is a key regulator of iron…
- Trial name
- NCT01991314
- Testing
- Ferrous sulphate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Queen Mary University of London
Aging
Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women
The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow…
- Trial name
- NCT03888040
- Testing
- Exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Marquette University
Multiple Sclerosis
MS Spinal Mobilisation Study
The objective of the study is to measure the effect of a spinal mobilisation intervention on para-spinal muscle tissue quality, functional balance measures, pain and fatigue in people with multiple sclerosis.
- Trial name
- NCT05090709
- Testing
- Spinal Mobilisation Intervention, General Massage
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Edinburgh Napier University
Advanced Cancer, Fatigue
Methylphenidate and a Nursing Telephone Intervention for Fatigue
The goal of this clinical research study is to learn if methylphenidate (Ritalin) can help to control fatigue caused by cancer. Its effect on other symptoms such as drowsiness, depression, sleeplessness, physical activity, and…
- Trial name
- NCT00424099
- Testing
- Methylphenidate, Nursing Telephone Intervention, Non NTI
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Malignant Solid Neoplasm, C-Reactive Protein Measurement
Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors
This phase II trial studies how well anamorelin hydrochloride, physical activity, and nutritional counseling work in decreasing cancer-related fatigue in patients with incurable solid tumors that have spread to other parts of the…
- Conditions
- Advanced Malignant Solid Neoplasm, C-Reactive Protein Measurement, Cancer Fatigue, Metastatic Malignant Solid Neoplasm
- Trial name
- NCT03035409
- Testing
- Anamorelin Hydrochloride, Exercise Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- M.D. Anderson Cancer Center