Clinical trials: Family Members
Cardiac Arrest, Post Traumatic Stress Syndrome
Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear)
The present study will: Aim 1: Enroll 15 family members of CA patients to (a) pilot recruitment procedures, (b) estimate retention, and (c) assess acceptability of study procedures.
- Trial name
- FAID Fear (NCT05144477)
- Testing
- FAID Fear Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Columbia University
Arrhythmogenic Right Ventricular Dysplasia, Brugada Syndrome
Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders
Every week in the UK, 12 apparently healthy and fit individuals under the age of 35 die suddenly, a tragic event known as sudden cardiac death (SCD).
- Conditions
- Arrhythmogenic Right Ventricular Dysplasia, Brugada Syndrome, Cardiac Channelopathy
- Trial name
- NCT04257994
- Testing
- obtaining a buccal smear sample
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- St. George's Hospital, London
Social Isolation, Loneliness
Mindfulness to Reduce Loneliness in Older Caregivers
The objective of this pilot study is to provide initial evidence of the role of mindfulness training in improving social disconnectedness - including social isolation and feelings of loneliness - in older caregivers for family…
- Trial name
- NCT04560088
- Testing
- Mindfulness, Breathing
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Rochester
Bereavement, Severe Grief Reaction
Supporting Family Members With Severe Grief Reaction During the COVID-19 Pandemic
This is a feasibility study taking place at The Ottawa Hospital (TOH), Hôpital Montfort, and Queensway Carleton Hospital that seeks to evaluate the impact of the COVID-19 pandemic on family member bereavement and study the effect…
- Trial name
- NCT04588415
- Testing
- Bereavement Virtual Support Group
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Heart Failure
Patient and Family Partners in Heart Failure Care: Pilot Test of a Pre-visit Question Prompt List to Enhance Engagement During Medical Visits
The purpose of this study is to conduct a pilot study in 30 Heart Failure (HF) patients and visit companions (i.e., a family member who accompanies the patient to medical visits), to evaluate a pre- visit question/topic prompt…
- Trial name
- NCT03491800
- Testing
- Question/Topic Prompt List
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of North Carolina, Chapel Hill
Anemia, Aplastic, Amegakaryocytic Thrombocytopenia
Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias
Due to an overall and disease free survival of 85% to 100%, allogeneic blood or bone marrow stem cell transplantation using an HLA matched sibling donor is the therapy of choice for patients with severe aplastic anemia (SAA).
- Conditions
- Anemia, Aplastic, Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Kostmann Syndrome
- Trial name
- NCT00244010
- Testing
- Allogeneic stem cell transplant
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Jude Children's Research Hospital
Psychotic Disorders, Psychosis
Pilot Study of Motivational Interviewing for Loved Ones
The study population for this research will include parents and concerned significant others (PCSO) of individuals experiencing recent (past five years) onset of a psychotic disorder (hereafter referred to as individuals with…
- Conditions
- Psychotic Disorders, Psychosis, Psychotic Episode
- Trial name
- MILO-Pilot (NCT04010747)
- Testing
- Motivational Interviewing for Loved Ones (MILO), Mental Health Services Consultation and Waitlist
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Boston Medical Center
Suicide
SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning
The management of suicide risk is a pressing national public health issue especially among Veterans, and there exist no guidelines of how best to involve family members in this effort.
- Trial name
- SAFER (NCT03034863)
- Testing
- Safe Actions for Families to Encourage Recovery, Individual Safety Planning Intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- VA Office of Research and Development
Influenza
Home Administration of FluMist by Parents/Caregivers
This study will examine the feasibility of having parents and caregivers administer FluMist live intranasal vaccine to their children at home outside the traditional medical environment and without the involvement of medical…
- Trial name
- NCT01938170
- Testing
- FluMist
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Lymphoma
Safety Trial of NK DLI From 6/6 HLA Matched Family Member Following Nonmyeloablative ASCT
Evaluate the safety of natural killer (NK) cell infusion using CD56 monoclonal antibody selected with Miltenyi Biotec system following nonmyeloablative stem cell transplantation (SCT) from matched donors.
- Trial name
- NCT00586690
- Testing
- NK Cell infusion using CD56 monoclonal antibody, Donor Apheresis
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- David Rizzieri, MD
Postintensive Care Syndrome, Family Members
Family Support Intervention in Intensive Care Units
Background: Family members of critically ill patients face considerable uncertainty and distress during their close other's intensive care unit (ICU) stay, with about 20-60% of family members experiencing post-traumatic distress…
- Conditions
- Postintensive Care Syndrome, Family Members, Quality of Life, Depression, Anxiety
- Trial name
- FICUS (NCT05280691)
- Testing
- Family Support Intervention (FSI)
- Where
- 12 sites in Switzerland
- Volunteers
- 885 people
- Sponsor
- Rahel Naef
Lymphoma, Myeloma
Allo Non-myeloablative SCT Utilizing Matched Family Member Stem Cells Purged Using Campath
Allogeneic transplantation is used to treat many malignant and non-malignant diseases, though the potential toxicities of the procedure remain high.
- Conditions
- Lymphoma, Myeloma, Leukemia, Myelodysplasia
- Trial name
- NCT00578942
- Testing
- Campath Purged Non-myeloablative ASCT
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- David Rizzieri, MD
Anxiety Disorder
Adjunctive Family CBT for Veterans With Anxiety
Despite the prevalence of posttraumatic stress disorder and anxiety disorders among Veterans, there has been limited focus on the development of interventions that include family members in treatments provided to Veterans.
- Trial name
- AF-CBT (NCT05340478)
- Testing
- Adjunctive Family - Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
Dementia, Alzheimer Disease
Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- Tele-STELLA (NCT04627662)
- Testing
- Tele-STELLA
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Oregon Health and Science University
Related Donors Donating PBSC to a Family Member, Healthy Donors
MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies
This research study tests a new medicine for mobilizing stem cells so they can be collected and used for allogeneic stem cell transplant for treatment of hematological malignancies.
- Conditions
- Related Donors Donating PBSC to a Family Member, Healthy Donors, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT04762875
- Testing
- MGTA-145, Plerixafor
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Ensoma
Substance Abuse
Telephone Coaching of Family Members of Veterans With Substance Abuse Problems
This project will develop and pilot test an enhanced, telephone "coaching" intervention to help family members concerned about a Veteran of the wars in Iraq or Afghanistan who needs to seek treatment for a substance abuse problem.
- Trial name
- VA-CRAFT (NCT03246646)
- Testing
- Coaching
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Hypogonadism
CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy
Testosterone (T) replacement prevents bone loss and relieves symptoms associated with androgen deficiency in male patients with hypogonadism, but at the expense of an increase in prostate-related adverse events and in the…
- Trial name
- NCT01378299
- Testing
- Testosterone Cypionate
- Where
- 2 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Family Members
Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19
This R01 project titled "Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19" is a Hybrid II RCT/implementation study to modify and test two of our alcohol smartphone…
- Conditions
- Alcohol Use Disorder, Family Members, Behavior, Addictive
- Trial name
- NCT05419128
- Testing
- PartnerCHESS, ACHESS
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Wisconsin, Madison
Brain Injuries, Traumatic, Transitional Care
Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Despite high risks of readmission and complex medical needs, there are no transitional care standards in the U.S. for patients with moderate-to-severe traumatic brain injury (TBI) discharged home from acute hospital care without…
- Conditions
- Brain Injuries, Traumatic, Transitional Care, Family Members, Patients
- Trial name
- R03 (NCT04584554)
- Testing
- BETTER Transitional Care Intervention
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University