Clinical trials: Facet Joint Disease
Low Back Pain
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain
This is a Pilot Study that is an open label, prospective, non-controlled study in which the safety and feasibility of Wharton's Jelly (WJ) allograft will be evaluated in 100 participants suffering with low back pain.
- Trial name
- NCT06361485
- Testing
- Lumbar Injections with 10cc's of Wharton's Jelly Allograft
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- R3 Stem Cell
Lumbar Facet Joint Syndrome
The Role of Intra-articular Injection of PRP Versus Corticosteriods in Treatment of Lumbar Facet Disease
Low back pain is an extremely common health problem and recent studies have shown that nearly up to 52% of patients have low back pain caused by lumbar facet joint syndrome.
- Trial name
- PRP (NCT04860531)
- Testing
- Lumbar Facet Joints intra-articular injection with Platelet Rich Plasma, Lumbar Facet Joints intra-articular injection with a mixture of 0.5% lidocaine and 5mg/ml of betamethasone
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Joint Pain
Synvisc Injections for Lumbar Facet Joint Pain
The objective of this investigation is to evaluate the safety and efficacy of viscosupplementation in treating symptomatic lumbar facet joint arthropathy.
- Trial name
- NCT00325845
- Testing
- Synvisc viscosupplementation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Sheltering Arms Physical Rehabilitation Hospitals
Low Back Pain
Effectiveness of Facet Joint Infiltration in Low Back Pain
The purpose of this study is to evaluate the effectiveness of facet joint infiltration with corticosteroids in the treatment of low back pain due to facet joint osteoarthritis.
- Trial name
- NCT01447160
- Testing
- Cortisone
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Arthropathy of Lumbar Facet, Pain, Back
Diagnostic Value of 18F-Fluoride-PET/MRI in the Management of Suspected Facet Joint Arthropathy
Prior to the injection, the facet joints have to be defined according to standard radiological techniques (e.g. MRI and physical correlation).
- Trial name
- NCT03317275
- Testing
- 18F-Fluoride-PET/MRI, facet injection, pain assessment by VAS
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Balgrist University Hospital
Facet Joint Pain
A Multi-Site Study of the Zyga GlyDer Facet Restoration Device In Subjects With LUmbar FacET Pain Syndrome - DUET
A non-randomized, multi-site feasibility study to evaluate the safety of the Glyder Device in subjects with a history of lumbar facet joint disease (L2 to the sacrum) and successful neural ablation in which the facet joint is…
- Trial name
- DUET (NCT02179476)
- Testing
- Glyder
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Zyga Technology, Inc.
Facet Joints; Degeneration, Neuropathy
MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root.
- Conditions
- Facet Joints; Degeneration, Neuropathy, Neuralgia
- Trial name
- NCT01788410
- Testing
- Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Rhizolysis, Diagnosis of Facet Joint Origin Lumbago
Determination of Predictive Clinical Signs of Effective Rhizolysis Using the DFL Questionnaire.
Rhizolysis or lumbar thermocoagulation is a therapeutic proposal for certain types of chronic lower back pain that is resistant to medical treatment and outside the field of surgical indications.
- Trial name
- Rhizolyse (NCT04118218)
- Testing
- Rhizolysis pain analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Facet Joint Pain
Multimodal PT With and Without Proprioceptive Training in Lumber FJS
This will be a randomized clinical trial. The study will be conducted at Pakistan Railways General Hospital Rawalpindi and Riphah International Hospital Islamabad. Patients with FJS will be included.
- Trial name
- NCT05931653
- Testing
- Multimodal Physical therapy, Proprioceptive training along with and Multimodal Physical therapy
- Where
- 3 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Facet-Mediated Low Back Pain
Allogeneic BM-MSCs in Patients with Lumbar Facet Arthropathy
Researchers are conducting this study to learn more about the side effects of bone marrow-derived stem cells when injected into the facet joints for the treatment of painful lumbar facet joint arthropathies.
- Trial name
- Cellkine (NCT04410731)
- Testing
- Single bilateral intra-articular injection of allogeneic BM-MSCs for lumbar facet joint arthropathy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Degenerative Disc Disease, Discogenic Low Back Pain
A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine
TDR implants for the lumbar spine are currently most 2- or 3-piece devices with a purely mechanical function that provide/restore mobility.
- Trial name
- NCT03716947
- Testing
- Device: ZACK, Device: ORBIT, Device: SASCA
- Where
- Sweden
- Volunteers
- 246 people
- Sponsor
- Karolinska Institutet
Chronic Low-back Pain
Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management.
The purpose of this study is to better understand how people feel after a radiofrequency ablation standard of care surgery using a different type of needle (multi-tined expandable electrode/MEE) in comparison to receiving…
- Trial name
- MEE (NCT04730700)
- Testing
- Radiofrequency Ablation with MEE, Conventional Medical Management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Kansas Medical Center
Low Back Pain, Disc Disease
Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs
Intradiscal delivery of bone marrow concentrate (BMC) into discs, facet, epidural space, and sacroiliac joints
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Arthropathy Vertebrae
- Trial name
- NCT04559295
- Testing
- Bone Marrow Concentrate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stem Cures
Vertebral Compression Fractures, Pathological Fracture
Prospective Evaluation of Therapeutic Combination in Treating Vertebral Compression Fractures
The purpose of this study is to collect clinical and radiographic outcomes in patients undergoing vertebroplasty procedures for the treatment of osteoporotic or pathological fractures of the vertebral body to understand the role…
- Conditions
- Vertebral Compression Fractures, Pathological Fracture, Facet Joint Arthropathy
- Trial name
- PROTECT (NCT06670404)
- Testing
- Vertebroplasty
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Prof Nicolas Theumann
Spinal Stenosis, Spinal Disease
Percutaneous Trans-facet Screw Fixation Under CT-scan Guidance for Remaining Symptoms at a Distance of Previous Spinal Surgery
Background : Segmental spinal instability after a laminectomy, and adjacent segment disease (ASD) at after an arthrodesis, are well-known concerns in spinal surgery, which may require re-interventions, usually by surgical…
- Conditions
- Spinal Stenosis, Spinal Disease, Zygapophyseal Joint Arthritis, Joint Instability
- Trial name
- NCT05525052
- Testing
- Trans-Facet fixation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis
To Compare Anterior Knee Pain Between Non Severe and Severe Patellofemoral Arthritis After Oxford UKA
The aims of this study is to compare the results between patients without severe patellofemoral arthritis and patients with severe patellofemoral arthritis after mobile bearing UKA.
- Trial name
- NCT02557763
- Testing
- Oxford unicompartmental knee arthroplasty
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Lumbar Degenerative Disc Disease, Lower Back Pain
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
Investigate the potential of tissue grafting that includes human mesenchymal stem cells in the repair and potential stabilization of the degenerative Lumbar disk and facet joint denovo and at the time of surgical reconstruction.
- Conditions
- Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT02529566
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Cervical Facet Joint Pain, Chronic Pain
Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
The investigators aim to determine whether cervical paravertebral muscle twitching during motor testing as part of performing cervical RFAs is associated with a greater likelihood of treatment success, and greater magnitude or…
- Conditions
- Cervical Facet Joint Pain, Chronic Pain, Neck Pain
- Trial name
- NCT05450679
- Testing
- Cervical Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Johns Hopkins University
Lumbar Fusion Surgery, Fusion of Joint
Evaluation of the Efficacy and Safety of Absorbable vs Traditional Bone Wax for Facet Fusion After Lumbar Fusion Surgery
Hemorrhage on the surface of cancellous bone presents a significant challenge in orthopedic surgery. Traditional bone wax, commonly utilized for hemostasis in bone wounds, is non-absorbable and associated with various…
- Trial name
- NCT07040293
- Testing
- Absorbable bone wax for hemostasis in the osteotomy surface of the facet joint, Traditional bone wax for hemostasis in the osteotomy surface of the facet joint
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Changzheng Hospital
Low Back Pain, Osteoarthritis
Platelet-rich Plasma Infiltration Versus Corticosteroid Infiltration (Prednisolone) in Treatment of Lumbar Facet Joint Syndrome
The prevalence of low back pain is estimated at 90% . Recent studies have shown that 15% to 52% of back pain is attributable to facet joint syndrome .
- Trial name
- IAPRP (NCT05105256)
- Testing
- Prednisolone, Platelet-rich plasma
- Where
- France
- Volunteers
- 76 people
- Sponsor
- CHU de Reims