Clinical trials: Eye Disorders
Choroidal Melanoma, Indeterminate Lesions
Choroidal Melanoma Patient-Reported Outcome Study (CM-PRO) in a Subset of AU-011-301 (CoMpass) Subjects
To assess subject-centric evidence of QoL outcomes in a subset of subjects enrolled in the global Phase 3 AU-011-301 clinical trial.
- Conditions
- Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
- Trial name
- NCT07421739
- Testing
- Non-interventional, digital, patient-reported, study
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Aura Biosciences
Vision Loss Partial, Vision; Loss, Both Eyes
Effect of Visual Retraining After Stroke
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and…
- Conditions
- Vision Loss Partial, Vision; Loss, Both Eyes, Hemianopia Homonymous, Hemianopia
- Trial name
- urochester (NCT06121219)
- Testing
- Training in the Blind Field
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cataract
Patient Participation in Free Cataract Surgery
Age-related cataracts remain the leading cause of treatable blindness in China. The prevalence of cataract blindness continues to climb due to the expanding elderly subpopulation.
- Trial name
- NCT02633865
- Where
- China
- Volunteers
- 883 people
- Sponsor
- Sun Yat-sen University
Dry Eye Disease
A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye
The purpose of this study is to evaluate the efficacy and safety of SI-614 ophthalmic solution compared with placebo in patients with dry eye
- Trial name
- SIDE (NCT05411367)
- Testing
- SI-614
- Where
- 6 sites in United States
- Volunteers
- 232 people
- Sponsor
- Seikagaku Corporation
Stargardt, Stargardt's Disease
An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene
This is an Observational Study to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene This is a multicenter study which will enroll approximately 75…
- Conditions
- Stargardt, Stargardt's Disease, Stargardt Disease, STGD1
- Trial name
- POLARIS (NCT06435000)
- Where
- 20 sites in United States, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- Splice Bio
Strabismic Amblyopia, Bilateral
Progression of Stereopsis Recovery in Strabismic Patients: A One-Month and Three-Month Post-Surgery Evaluation
This prospective longitudinal observational study aims to assess stereopsis recovery in strabismic patients at one month and three months post-corrective surgery.
- Trial name
- NCT06913400
- Testing
- Stereopsis Recovery
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Superior University
Metabolomics; Retinopathy; Etiology
Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was…
- Trial name
- NCT06408571
- Testing
- etiology
- Where
- China
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Dry Eye Syndrome, Ocular Surface Disease
Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface
The main objective is to describe the characteristics of dry eye syndrome before and after surgery at one month of cataract surgery, using a multimodal analysis of the ocular surface.
- Trial name
- C-SS0 (NCT03923244)
- Testing
- OSDI survey
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Retinal Vein Occlusion (RVO), Macular Edema
Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF
To determine if Ozurdex implant can offer an effective treatment for macular edema associated with retinal vein occlusion when treatment with intravitreal Avastin, Lucentis, or Eylea have not demonstrated a significant response.
- Trial name
- NCT01946399
- Testing
- Ozurdex implant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Research Institute, LLC
Glaucoma
Triamcinolone for Ahmed Glaucoma Valve
This triple-blind, stratified, randomized clinical trial includes 100 eyes of 100 patients aged 18 to 85 years with refractory glaucoma.
- Trial name
- NCT02653963
- Testing
- Adjunctival Triamcinolone
- Where
- Iran
- Volunteers
- 106 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinitis Pigmentosa
Phase 1 Study of Intravitreal Autologous CD34+ Stem Cell Therapy for Retinitis Pigmentosa
In this Phase 1 open-labeled prospective study, one eye of each participant with vision loss from retinitis pigmentosa will be administered intravitreal injection of autologous CD34+ stem cells harvested from bone marrow.
- Trial name
- BMSCRP1 (NCT04925687)
- Testing
- Intravitreal autologous CD34+ cells
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Davis
Vision, Low
Retina Projection System Trials for Low Vision People
1. Purpose a. Examination on Efficacy of Retina Projection System 2. Patients a. Low vision patients 3. Methods 1. Vision aids Retina Projection System Face-mounted video display as control 2.
- Trial name
- NCT00219427
- Where
- 6 sites in Japan
- Volunteers
- 58 people
- Sponsor
- Osaka City University
Uveitis
Influencing Factors in Uveitis
Environmental factors possibly influencing uveitis are evaluated.
- Trial name
- NCT00827086
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- St. Franziskus Hospital
Glaucoma
Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-3)
This prospective, single-arm clinical multicenter study intends to measure normal structural parameters of the optic nerve head, the peripapillary retinal nerve fiber layer, and the macula using the Heidelberg Spectralis OCT…
- Trial name
- NCT02785042
- Testing
- Heidelberg Spectralis OCT
- Where
- 8 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Myopia
Topography-Guided Customized PRK Versus Q-value Adjusted PRK in Correction of Myopia With or Without Astigmatism
This study will include patients who will undergo PRK in both eyes, for each patient each eye will be randomly allocated to one of 2 procedures: topography-guided ablation in one eye (group I) and Q-factor customized ablation in…
- Trial name
- NCT03291873
- Testing
- PRK
- Where
- 2 sites in Egypt
- Volunteers
- 104 people
- Sponsor
- Kasr El Aini Hospital
Dementia, Mild Cognitive Impairment
Eye Scanning for Safety Driving
This is an experimental study protocol to investigate the use of vision-based assessments like eye-tracking and visual processing tests to evaluate driving ability in older adults with and without dementia.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adults
- Trial name
- NCT06396273
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Retinal Detachment
Comparison High-density Silicone Oils in Retinal Detachment
The purpose of the study is to compare the safety, intraocular adverse effects and the anatomic and functional outcome with two endotamponade silicone oil after a 3-month in complex inferior retinal re-detachments.
- Trial name
- NCT00403702
- Testing
- Oxane HD [oil-RMN3-mixture], Densiron [(F6H8)
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Stroke, Blindness
Functional Neuroimaging of Cortical Plasticity in the Human Visual System
The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways.
- Conditions
- Stroke, Blindness, Vision
- Trial name
- NCT01062672
- Where
- 2 sites in United States, Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Retinitis Pigmentosa (RP)
Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection)
This is a Phase 1/2, multi-center, randomized, sham-controlled, dose-escalation study evaluating ZM-02 in patients with advanced retinitis pigmentosa (RP).
- Trial name
- PRISM (NCT07282457)
- Testing
- ZM-02 (low dose), ZM-02 (high dose), ZM-02 (selected dose)
- Volunteers
- 21 people
- Sponsor
- Zhongmou Therapeutics
Uveitis
UNICORNS: Uveitis in Childhood Prospective National Cohort Study
Childhood uveitis (inflammation inside the eye) is an uncommon disorder that carries the risk of blindness. Inadequate treatment of active inflammation has been shown to be related to a poor outcome.
- Trial name
- UNICORNS (NCT05385757)
- Where
- 31 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- Institute of Child Health