Clinical trials: Extubation Failure
Sleep Quality, Extubation Failure
Sleep Quality in Intensive Care Unit Patients at High Risk of Extubation Failure
The aim of the study is to evaluate the impact of sleep quality on extubation failure rate in intensive care unit patients at high risk.
- Trial name
- WEAN SLEEP 2 (NCT02911506)
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Poitiers University Hospital
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Unplanned Extubation, Self Extubation
Unplanned-extubation in the ICU; Incidence, Characteristics and Prognosis. Success And Failure of Self-Extubation in the ICU
Our study consists of a national observational study assessing quantitatively (incidence) and qualitatively unscheduled extubation in intensive care unit.
- Trial name
- SAFE-ICU (NCT04992117)
- Testing
- NO INTERVENTION
- Where
- France
- Volunteers
- 633 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Systolic Heart Failure, Respiratory Failure
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical…
- Trial name
- EXTUBATE-HF (NCT06671015)
- Testing
- Airvo 3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Obesity, Morbid, Extubation Failure
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing.
- Trial name
- NCT05918575
- Testing
- Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula
- Where
- 5 sites in United States, Mexico
- Volunteers
- 250 people
- Sponsor
- Rush University Medical Center
Mechanical Ventilation Complication, Weaning Failure
Preventing Failed Extubations
More than 300,00 people in the United States experience acute respiratory failure and require mechanical ventilation every year.
- Trial name
- PreFIX (NCT06301867)
- Testing
- Plateau Pressure
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Duke University
Morbid Obesity, Weaning Failure
Preoperative Exercise Test and Postoperative Intensive Care Unit Need in Bariatric Surgery
The aim of our study is to evaluate the efficacy of "60 meters 60 seconds exercise test" (a test designed by the study group) done preoperatively as a predictor test for postoperative intensive care unit need and extubation…
- Trial name
- NCT03419104
- Testing
- preoperative walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University
Covid19, Respiratory Failure
Nebulised Heparin in Patients With Severe COVID-19
The Can nebulised HepArin Reduce morTality and time to Extubation in Patients with COVID-19 Requiring mechanical ventilation Meta-Trial (CHARTER-MT) is a prospective collaborative individual patient data analysis of randomised…
- Trial name
- CHARTER-MT (NCT04545541)
- Testing
- Nebulised unfractionated heparin (UFH)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Australian National University
Ventilator Weaning
Transcutaneous Carbon Dioxide Pressure (tcPCO2) Monitoring for the Prediction of Extubation Failure in the ICU
Difficult weaning from ventilation and extubation failure are major issues in intensive care, concerning 30% and 12% of patients respectively.
- Trial name
- tcPCO2 (NCT02894177)
- Testing
- tcPCO2 measurement
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Versailles Hospital
Acute Brain Injury, Post-neurosurgical Status
High-Flow Nasal Cannula After Extubation in Acute Brain Injury
Patients with acute brain injury after neurosurgery are at increased risk of extubation failure after removal of the endotracheal tube.
- Conditions
- Acute Brain Injury, Post-neurosurgical Status, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07664085
- Where
- Vietnam
- Volunteers
- 285 people
- Sponsor
- Bach Mai Hospital
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Neonatal Disease
Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure
The objective of the study is to evaluate the role of neonatologist-performed lung ultrasound (NPLUS) after weaning from invasive mechanical ventilation and extubation.
- Trial name
- NCT06469580
- Testing
- NPLUS (neonatologist performed lung ultrasound)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Respiratory Failure
Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
The aim of this study was to compare the indices of rapid shallow breathing, neuromechanical efficiency (NME), and neuroventilatory efficiency (NVE) between patients being successfully extubated and those who failed weaning.
- Trial name
- NCT01065428
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Southeast University, China
Prediction of Extubation Readiness
Prediction of Extubation Readiness in Extreme Preterm Infants by the Automated Analysis of CardioRespiratory Behavior
The investigators hypothesize that machine learning methods using a combination of novel, quantitative measures of cardio-respiratory variability can accurately predict the optimal time to extubate extreme preterm infants.
- Trial name
- NCT01909947
- Testing
- Cardiorespiratory signal acquisition
- Where
- 5 sites in United States, Canada
- Volunteers
- 266 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Respiratory Failure, Mechanical Ventilation
External Validation of AI-Aided Weaning Software Using Multicenter Retrospective Data
This multicenter retrospective study aims to externally validate an artificial intelligence-aided weaning software developed using intensive care unit data from Taichung Veterans General Hospital between 2015 and 2019.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Critical Illness
- Trial name
- NCT07658131
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Taichung Veterans General Hospital