Clinical trials: Extracorporeal Membrane Oxygenation Complication
COVID-19, Extracorporeal Membrane Oxygenation Complication
Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome
- Trial name
- NCT04383678
- Testing
- Extracorporeal membrane oxygenation
- Where
- 11 sites in Finland, France and 4 more
- Volunteers
- 132 people
- Sponsor
- Helsinki University Central Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Impact of ECMO Cannula Chlorhexidine-impregnated Dressings to Decrease Extracorporeal Membrane Oxygenation-cannula Related Infection Rate
The Dressing-ECMO trial is a prospective, open-label, multicenter, controlled trial randomizing patients who received percutaneous ECMO to cannula chlorhexidine-impregnated dressing vs standard dressing.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome, Infections
- Trial name
- DRESSING-ECMO (NCT05750576)
- Testing
- Chlorhexidine-impregnated dressings, Non impregnated dressings
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation Complication
Bivalirudin vs Heparin in ECMO Patients
This is an open label, randomized study comparing the clinical outcomes of unfractionated Heparin and Bivalirudin for anticoagulation in adult subjects requiring ECMO support.
- Trial name
- NCT03707418
- Testing
- Heparin Sodium, Bivalirudin Injection [Angiomax]
- Where
- United States
- Sponsor
- Johns Hopkins University
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Critical Illness, Extracorporeal Membrane Oxygenation Complication
PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation Treatment
Extracorporeal membrane pulmonary oxygenation (ECMO) may provide partial or complete support for organ replacement in patients with severe cardiopulmonary failure, buying time for further management of the primary disease.
- Trial name
- ECMO (NCT06319677)
- Testing
- ECMO treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Extracorporeal Membrane Oxygenation Complication
Transplantation of Autologously Derived Mitochondria Following Ischemia
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation…
- Trial name
- NCT02851758
- Testing
- autologous mitochondria transplantation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation Complication
Early Rehabilitation in Patients on Extracorporeal Membrane Oxygenation
Critically ill patients who require extracorporeal membrane oxygenation (ECMO) are the sickest in the hospital. More patients are surviving but survivors have compromised functional recovery for months or years.
- Trial name
- ECMO-Rehab (NCT05003609)
- Testing
- Early Rehabilitation
- Where
- 7 sites in Australia, Canada
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Extracorporeal Membrane Oxygenation Complication
Application of Early Physical Therapy Regimens in Patients With Veno-venos Extracorporeal Membrane Oxygenation
Promote early recovery through the application of early physiotherapy programs for VV-ECMO patients
- Trial name
- VV-ECMO (NCT04918498)
- Testing
- early physiotherapy programs, routine treatment
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
COVID-19 Pneumonia, Extracorporeal Membrane Oxygenation Complication
Safety and Feasibility of Percutaneous Dilatational Tracheostomy in Patients With Severe COVID-19 Supported by ECMO
COVID-19 pandemic has presented the global health care systems with unprecedented and unexpected challenges. The clinical spectrum of COVID-19 disease varies from mild, at times asymptomatic, to severe life-threatening multiple…
- Conditions
- COVID-19 Pneumonia, Extracorporeal Membrane Oxygenation Complication, Tracheostomy Complication, Respiratory Failure
- Trial name
- NCT05045885
- Where
- Qatar
- Volunteers
- 32 people
- Sponsor
- Hamad Medical Corporation
Extracorporeal Membrane Oxygenation Complication, Transfusion Related Complication
PRospective Multicenter Observational Study on Transfusion Practice in Vv-ECMO Patients: The PROTECMO Study
Background: Over the past decade, the use of extracorporeal membrane oxygenation (ECMO) for respiratory support in adults has increased.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Transfusion Related Complication, Hemorrhage, Anticoagulant-induced Bleeding
- Trial name
- PROTECMO (NCT03815773)
- Where
- Italy
- Volunteers
- 656 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)
Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients.
- Conditions
- Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications
- Trial name
- UPV-ECMO (NCT03041428)
- Testing
- Ultraprotective ventilation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Extracorporeal Membrane Oxygenation Complication
ECMO: Optimization of Its Use
To create a local registry for ECMO patients.
- Trial name
- NCT02280460
- Where
- United States
- Volunteers
- 921 people
- Sponsor
- Renzo Loyaga Rendon
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication
Platform of Randomized Adaptive Clinical Trials in Critical Illness
PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states…
- Conditions
- Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
- Trial name
- PRACTICAL (NCT05440851)
- Testing
- Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL)
- Where
- 103 sites in United States, Australia and 8 more
- Volunteers
- 6,250 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury
Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
- Trial name
- NCT02978378
- Testing
- biomarker levels
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Milton S. Hershey Medical Center
Extracorporeal Membrane Oxygenation Complication
TEG Anticoagulation Monitoring During ECMO
The best anticoagulation strategy during Extracorporeal Membrane Oxygenation (ECMO) is unknown. Actual recommendations suggest to use unfractionated heparin infusion and monitor the effect with either activated Partial…
- Trial name
- NCT02271126
- Testing
- TEG monitoring, APTT monitoring, Heparin
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Policlinico Hospital
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support
The potential role of ATIII in achieving and maintaining adequate anticoagulation in pediatric patients on the heart-lung machine has recently taken on increased importance as caregivers strive to mitigate the risk for clinically…
- Trial name
- NCT02631174
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Extracorporeal Membrane Oxygenation Complication
The ECMO-Free Trial
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost.
- Trial name
- NCT05486559
- Testing
- ECMO-free protocol, Usual Care
- Where
- 8 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Long Term Adverse Effects, Pneumonia
Long-term Follow Up of Adult Patients Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure
Follow-up after treatment with Extracorporeal Membrane Oxygenation (ECMO) at the ECMO Center Karolinska. Patients: adult survivors treated with ECMO for severe refractory respiratory failure at least 5 years earlier.
- Conditions
- Long Term Adverse Effects, Pneumonia, Acute Respiratory Distress Syndrome, Sepsis
- Trial name
- NCT03031275
- Testing
- High-resolution computed tomography, Magnetic resonance imaging, Cognitive testing
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital