Clinical trials: Extracorporeal Life Support
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock.
- Trial name
- LEVOECMO (NCT04728932)
- Testing
- Levosimendan
- Where
- 3 sites in France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
AMI - Acute Mesenteric Ischemia, Extracorporeal Membrane Oxygenation Complication
Risk Factors Analysis for Acute Myocardial Infarction Patients
ECMO has been used to save the lives of many critically ill patients with cardiorespiratory dysfunction as important rescue therapy.
- Trial name
- NCT05390658
- Testing
- Not application
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Genglong Liu
Cardiogenic Shock, ECMO
Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation
Midazolam and propofol are the most used intravenous (IV) sedative agents, but their use is associated with well-known adverse effects such as accumulation, myotoxicity, tachyphylaxis, and unpredictable wake-up time.
- Trial name
- INSEPTION (NCT07099014)
- Testing
- Inahled Isoflurane, Propofol, midazolam
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation Complication, Thrombosis
D-dimer to Improve Anticoagulation Outcome During ECMO loNg-term supporteD
This was a prospective, cohort study.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Thrombosis, Hemorrhage, Heparin Overdose
- Trial name
- DIAMOND (NCT03261284)
- Testing
- D-dimer-guided adjustment stratege, Thepeautic-heparin therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wuhan Asia Heart Hospital
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Sepsis
Cefiderocol PK in Patients on ECMO
Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary life-support for critically ill patients where blood is extracted from the vascular system and circulated by a mechanical pump while it is oxygenated and…
- Trial name
- NCT04995835
- Testing
- Cefiderocol
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Joseph L. Kuti, PharmD
Elective Cardiac Surgery
CytoSorb Reduction of Free Hemoglobin During Cardiac Surgery
Prospective, multi-center, randomized, feasibility clinical study. Subjects will be randomized in a 1:1 ratio to either standard of care (SOC) alone or standard of care and treatment with the CytoSorb® device.
- Trial name
- REFRESH (NCT02566525)
- Testing
- CytoSorb
- Where
- 8 sites in United States
- Volunteers
- 52 people
- Sponsor
- CytoSorbents, Inc
Cardiac Arrest, Myocardial Infarction
Monitoring Antiplatelet Drugs in Cardiac Arrest Patients
Dual Antiplatelet Therapy (DAPT) with acetylsalicylic acid (ASA) and oral P2Y12 inhibitor (Clopidogrel, Ticagrelor or Prasugrel) is recommended in STEMI or NSTEMI patients undergoing primary Percutaneous Coronary Intervention…
- Conditions
- Cardiac Arrest, Myocardial Infarction, Extracorporeal Membrane Oxygenation, Platelet Dysfunction
- Trial name
- PLT-ECMO (NCT05730114)
- Testing
- Antiplatelet Drug
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milano Bicocca
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Extracorporeal Membrane Oxygenation, Extracorporeal Membrane Oxygenation Complication
PREdiCtIon of Weanability, Survival and Functional outcomEs After ECLS
Extracorporeal life support (ECLS) is used as a last resort intervention in patients with severe cardiac, circulatory and/or respiratory failure with high (>80%) expected mortality.
- Trial name
- PRECISE - ECLS (NCT05444764)
- Where
- 6 sites in Netherlands
- Volunteers
- 800 people
- Sponsor
- UMC Utrecht
Critical Illness, Extracorporeal Membrane Oxygenation Complication
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Observational study Primary Objective: To study whether ECMO alters the PK of anti-infectives including voriconazole, posaconazole and caspofungin in critically ill patients on ECMO Secondary Objectives: Develop Population PK…
- Conditions
- Critical Illness, Extracorporeal Membrane Oxygenation Complication, Infection
- Trial name
- EAT-PK (NCT04674657)
- Testing
- blood drug concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
VV ECMO, Bleeding
Incidence of Bleeding, Thrombosis and Transfusion Requirements in ICU Patients With COVID-19 Supported With Veno-venous Extracorporeal Membrane Oxygenation
The investigators aim to assess the risk of bleeding and thrombo-embolic complications as well as benefit and harm of blood product transfusion and anticoagulation therapy in adult ICU patients with COVID-19 supported with V-V…
- Conditions
- VV ECMO, Bleeding, Thrombosis, Transfusion Adverse Reaction
- Trial name
- NCT07352072
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Extra Corporeal Membrane Oxygenation
Acute Neurological Complications and Neurodevelopmental Outcome in Children Undergoing Extracorporeal Membrane Oxygenation.
The purpose of this retrospective study is to describe the different types of acute neurologic complications in children who underwent extracorporeal membrane oxygenation (ECMO), and their risk factors.
- Trial name
- NeurECMO (NCT04519528)
- Testing
- DENVER scale (under 2 years old) or Pediatric Cerebral Performance Category (PCPC) score (over 2 years old), Pediatric Quality of Life Inventory™ (PedsQL)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
- Trial name
- NCT02978378
- Testing
- biomarker levels
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Milton S. Hershey Medical Center
Long Term Adverse Effects, Pneumonia
Long-term Follow Up of Adult Patients Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure
Follow-up after treatment with Extracorporeal Membrane Oxygenation (ECMO) at the ECMO Center Karolinska. Patients: adult survivors treated with ECMO for severe refractory respiratory failure at least 5 years earlier.
- Conditions
- Long Term Adverse Effects, Pneumonia, Acute Respiratory Distress Syndrome, Sepsis
- Trial name
- NCT03031275
- Testing
- High-resolution computed tomography, Magnetic resonance imaging, Cognitive testing
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
ICU Acquired Weakness
Risk Factors of ICU-acquired Weakness
We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score < 48 out of a maximal…
- Trial name
- ICU-AW (NCT04932330)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Respiratory Failure
Lung Transplantation in Respiratory Failure Patients
Survival after cadaveric lung transplantation in recipients depended on ventilation support prior to transplantation has been reported to have relative high surgical mortality and morbidity rate.
- Trial name
- NCT00854165
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Shock, Respiratory Failure
Analysis of Endotoxin Activity in Patients With ECMO
Extra-corporeal membrane oxygenation (ECMO) can temporarily help patients gain time to wait for cardiopulmonary recovery or further treatment in patients with cardiopulmonary failure.
- Trial name
- NCT03978728
- Testing
- Extra-corporeal membrane oxygenation
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Taiwan University Hospital
Extracorporeal Membrane Oxygenation
Impact of the Implementation of a Referral Veno-venous Extracorporeal Membrane Oxygenation Centre on Mortality
Current evidence suggest that regrouping patient supported by veno-venous ECMO in high-volume centre could improve outcome. A dedicated ECMO unit was implemented in Dijon.
- Trial name
- ECMO UNIT (NCT05154071)
- Testing
- Collection of medical data
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Antithrombin III Deficiency, Extracorporeal Membrane Oxygenation Complication
Prospective Investigation of Antithrombin III Deficiency in Adult Patients With ECMO
There are publications showing a decrease in Antithrombin III levels of continuous flow and routine heparin therapy in adult patients undergoing Extracorporeal Membrane Oxygenation (ECMO) however, there is not enough data.
- Trial name
- NCT04879550
- Testing
- Antithrombin III
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital