Clinical trials: Exposure, Environmental
Noise Exposure, Surgery
Noise in the OR at Induction: Patient and Anesthesiologists Perceptions
Noise in the operating room is common and often unavoidable, but there is mixed evidence of its impact. Previous research has suggested that excessive noise at the time when a patient is being 'put to sleep' may lead to care…
- Conditions
- Noise Exposure, Surgery, Patient Satisfaction, Anesthesia
- Trial name
- NCT04204785
- Testing
- Noise Reduction Education
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Physical Inactivity, Environmental Exposure
Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes
By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas.
- Conditions
- Physical Inactivity, Environmental Exposure, Mental Health Wellness 1
- Trial name
- NCT05865782
- Testing
- Schoolyard reconstruction
- Where
- Sweden
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Development
Childhood Measures of NICU-based Chemical Exposure
This study aims to identify early life exposures to metals and chemicals by measuring the concentration of metals and organic compounds in shed primary teeth.
- Trial name
- NCT02292680
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ragweed Allergy, Rhinoconjunctivitis
ToleroMune Ragweed Follow up Study
Ragweed is the primary cause of autumn allergies. The ragweed season begins in mid-August. In the third National Health and Nutrition Examination Surveys54.3% of the population had positive test responses to one or more…
- Trial name
- NCT01448603
- Testing
- ToleroMune Ragweed
- Where
- Canada
- Volunteers
- 109 people
- Sponsor
- Circassia Limited
Lung Neoplasms
Smoky Coal Exposure, Genetic Susceptibility, and Lung Cancer in Non-Smoking Women in China
Background: Women in Xuan Wei County, China, are almost all non-smokers, yet they have the highest lung cancer rate in that country.
- Trial name
- NCT00482118
- Where
- 4 sites in China
- Volunteers
- 3,720 people
- Sponsor
- National Cancer Institute (NCI)
Nasal Allergies, Allergies
Safety and Efficacy of AL-53817 Nasal Spray Solution
The purpose of this study was to determine the maximum tolerated dose of AL-53817 (Stage A) and evaluate the safety and efficacy of AL-53817 for the treatment of allergic rhinitis (Stage B).
- Trial name
- NCT01454505
- Testing
- AL-53817 nasal spray solution, Vehicle nasal spray
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
D001305, Auditory Fatigue
Fatigue and Hearing Performance of Healthy Volunteers Acutely Exposed to Occupational Noise ( FATIGAUDIT)
Occupational noise exposure is regulated by law, and protective measures are applied if the noise level exceeds 90 dB(A). The inferior exposure levels can cause an auditory fatigue which is defined as temporary and reversible…
- Conditions
- D001305, Auditory Fatigue, Noise Exposure, Environmental Noise
- Trial name
- FATIGAUDIT (NCT07604077)
- Testing
- 2h30 of noise exposure at 85 dB(A), 2 noise exposures of 66 minutes, 10 noise exposure cycles
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Dry Eye
Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)
Hypothesis: Fluorometholone (FML) 0.1% eyedrops topically applied 4 times a day for 22 days is more efficient than artificial tears (Liquifilm) in dry eye disease (DED) and ameliorates the worsening of the disease after exposure…
- Trial name
- FML (NCT02051023)
- Testing
- FML 0.1% eyedrops, Liquifilm artificial tears eyedrops
- Where
- 2 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Sars-CoV2
Prevalence of COVID-19 Infection Among HCW in a French University Hospital
The objective of this study is to determine the prevalence of SARS-Cov2 infection among health care workers exposed of Lille University Hospital, to describe its evolution during the epidemic taking into account the influence of…
- Trial name
- EXPOCOVIA (NCT04371692)
- Testing
- self-administered questionnaire, SARS-Cov2 testing
- Where
- France
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Noise Exposure
The Effect of a Reduced Noise Environment on the Response Time of the Anesthesia Provider
This project will investigate whether reduction in ambient light and elimination of noise during induction and emergence from anesthesia influences the response time of the anesthesia provider to auditory and visual alarms when…
- Trial name
- NCT03507855
- Testing
- Reduced noise, Normal
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Joshua Uffman
Environmental Exposure
Intervention to Reduce Bisphenol A Exposure in Women
The purpose of this study is to determine whether a 3-week intervention reduces urinary Bisphenol A (BPA) in women with obesity
- Trial name
- NCT03440307
- Testing
- Face-to-Face Meetings, Email Only
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
House Dust Mite Allergy, Rhinoconjunctivitis
ToleroMune House Dust Mite Follow on Study
House Dust Mites (HDM) are arachnids that infest bedding, carpet, upholstered furniture and fabric. Like many other allergens, exposure to HDM allergens in sensitised patients is associated with poorer lung function, greater…
- Trial name
- NCT01923792
- Volunteers
- 105 people
- Sponsor
- Circassia Limited
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Postpartum Depression, Pregnancy Related
Nurtured in Nature
The investigators pilot test a Nature Coach Intervention in a population of postpartum women, to increase the amount of time people spend outside in local nature, with the goal of preventing postpartum depression.
- Conditions
- Postpartum Depression, Pregnancy Related, Environmental Exposure
- Trial name
- NCT04146025
- Testing
- Nature Coach Intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
Somatic Mutation
Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
The goal of this study is to This research team is conducting this study to develop methods to measure the biological impact of exposure to the chemicals released following the February 3, 2023 train derailment on residents of…
- Trial name
- NCT06357845
- Testing
- Survey, Biological specimen collection, Communications about study updates and future research opportunities
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Parkinson Disease, Secondary
Study on the Relationship Between Environmental and Occupational Exposure to Metals and Parkinson's Disease
The Department of Experimental Medicine - Section of Hygiene, Occupational Medicine, Forensic Medicine of the Second University of Naples, the Section of Neurology of the Second University of Naples and the Mediterranean…
- Trial name
- NCT02588924
- Testing
- Second University of Naples, Neuromed IRCCS
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Allergic Rhinitis, Allergy to Pollen
Evaluation of the Nasal and Conjunctival Response in Subjects Allergic to Birch Pollen in the ALYATEC Environmental Exposure Chamber
The aim of this study is to assess the nasal and conjunctival response in subjects allergic to birch pollen during controlled exposures in the ALYATEC environmental exposure chamber (EEC)
- Conditions
- Allergic Rhinitis, Allergy to Pollen, Rhinoconjunctivitis
- Trial name
- NCT04583202
- Testing
- Exposure to allergen
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Alyatec
Stroke
Comparison of Training in Virtual Environment With and Without Physiotherapeutic Intervention in Chronic Stroke Patients
The aim of this study is to compare the effects of balance training in a virtual environment with and without physiotherapeutic intervention on the motor function, balance and gait in chronic stroke patients.
- Trial name
- NCT03361241
- Testing
- No Physiotherapeutic Intervention, Physiotherapeutic Intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Allergy to House Dust Mite
Validation of an Environmental Exposure Chamber for Inhalation Studies With House Dust Mite Allergen in Patients With Allergic Rhinitis
This clinical validation study is aimed at testing the efficacy of a new environmental challenge chamber (ECC) to induce symptoms of allergic rhinitis in patients allergic to house dust mite.
- Trial name
- NCT01275456
- Testing
- Exposure to house dust mite
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Rhinoconjunctivitis, Grass Allergy
ToleroMune Grass Follow on Study
Grass pollen allergens are recognised as a major cause of allergic diseases in humans and animals. Worldwide, at least 40% of allergic patients are sensitised to grass pollen allergens and between 50-90% of hayfever or seasonal…
- Trial name
- NCT02292875
- Where
- 2 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Circassia Limited