Clinical trials: Exercise Intolerance
Heart Defects, Congenital
Rehabilitation in Patients With Congenital Heart Disease
Exercise intolerance is a major burden for patients with complex congenital heart disease (CHD), significantly affecting their quality of life.
- Trial name
- CARE-GUCH (NCT01463800)
- Testing
- Structured exercise training
- Where
- 4 sites in Spain, Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Basel, Switzerland
Orthostatic Hypotension, Heart Rate
Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.
Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid…
- Conditions
- Orthostatic Hypotension, Heart Rate, Blood Pressure
- Trial name
- NCT07579026
- Testing
- diaphragmatic breathing exercise, educational retraining
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Electroretinography
The Electroretinogram in Healthy and Glucose Intolerant Young Men
The purpose is to investigate the electroretinogram (ERG) in young, healthy men in the normoglycaemic and hyperglycaemic state before and after intervention with corticosteroids treatment, high calorie diet and exercise restraint.
- Trial name
- NCT01140932
- Testing
- Prednisolone, Lifestyle change
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Heart Failure
Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure With Preserved Ejection Fraction (KNO3CK OUT HFPEF)
This trial seeks to assess if potassium nitrate (KNO3) therapy improves exercise capacity and oxygen uptake in heart failure patients with preserved ejection fraction (HFpEF).
- Trial name
- NCT02840799
- Testing
- Potassium Nitrate (KNO3), Potassium Chloride (KCl)
- Where
- 3 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of Pennsylvania
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
Sedentary Lifestyle, Hyperinsulinemia
Developing a Physiological Understanding of High Duration Activity
When muscles are not contracting, the local energy demand by muscle and use of specific fuels used to produce energy by oxidative metabolism are minimal.
- Conditions
- Sedentary Lifestyle, Hyperinsulinemia, Glucose Tolerance Impaired, Low-density-lipoprotein-type
- Trial name
- NCT05135234
- Testing
- Muscular Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Houston
Heart Failure, Diastolic, Obesity
Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
The purpose of this study is to examine the effects of weight loss via hypocaloric diet (CR)and aerobic exercise (AT) compared to the effects of weight loss via hypocaloric diet (CR), aerobic training (AT)and resistance training…
- Trial name
- SECRET-II (NCT02636439)
- Testing
- dietary, aerobic and resistance training, dietary, and aerobic exercise
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease
Diabetes, Exercise and Liver Fat (DELIVER)
This randomised controlled trial will determine if exercise (150 - 200 min per week, 6 weeks) can beneficially modify liver fat quality in non alcohol fatty liver disease patients with type 2 diabetes mellitus (n = 26, 13 per…
- Conditions
- Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity, Insulin Resistance
- Trial name
- (DELIVER) (NCT04004273)
- Testing
- Exercise
- Where
- 4 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- James King
Kidney Failure, Chronic
Exercise Intolerance in Renal Failure
Patients with chronic kidney disease have profound exercise intolerance which contributes to an increased risk of cardiovascular disease.
- Trial name
- EIRF (NCT01356966)
- Testing
- Tetrahydrobiopterin, Folate
- Where
- 2 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-COVID Syndrome
Exercise Intolerance in Post-COVID Patients
The post-COVID syndrome poses an unprecedented challenge to modern society, affecting millions of people worldwide. Persistent fatigue and exercise intolerance are among the most common complaints of these subjects.
- Trial name
- EXILE (NCT05445830)
- Testing
- High-Intensity-Interval-Exercise, Moderate-Intensity-Continuous-Exercise, Strength training
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Heart Failure With Normal Ejection Fraction
Exercise Intolerance in Heart Failure
The investigators are studying whether metabolic abnormalities in cardiac and skeletal muscle in patients with heart failure with preserved ejection fraction (HFpEF) are associated with debilitating exercise intolerance.
- Trial name
- NCT03775577
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Sedentary Lifestyle, Physical Activity
A Mobile Based Diabetes Prevention Program
The goals of the study are to: 1. Assess effect sizes of our mDPP intervention on weight loss, physical activity, dietary intake, and fasting plasma glucose (FPG) levels from baseline to 5 months as compared to a control group.
- Conditions
- Sedentary Lifestyle, Physical Activity, Pre-Diabetic
- Trial name
- NCT01579292
- Testing
- Mobile phone based physical activity with intervention, Pedometer Only
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pre-diabetes
Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes
Newly released guidelines recommend increased physical activity (PA) and reduced sedentary behaviors (SB) to improve glycemia and prevent the onset and progression of type 2 diabetes (T2D).
- Trial name
- BURST2D (NCT05041491)
- Testing
- BREAK, ONE
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Diabetes, Neuropathy
Improving Autonomic Function and Balance in Diabetic Neuropathy
Type 2 diabetes (DM2) affects nearly 20 million people in the United States while impaired glucose regulation (IGR), which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and early diabetes affects a…
- Conditions
- Diabetes, Neuropathy, Impaired Glucose Tolerance
- Trial name
- IMABIN (NCT01864460)
- Testing
- lifestyle modification
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- VA Office of Research and Development
Covid19, Dyspnea
Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19
A novel corona virus emerged in 2019 causing Corona Virus Disease 2019 (covid-19). In one year more than 80 000 000 cases worldwide were documented.
- Trial name
- NCT04732663
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
HFpEF
Muscle Blood Flow Regulation in HFpEF
Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System.
- Trial name
- NCT05115890
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
COPD (Chronic Obstructive Pulmonary Disease)
Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD
The goal of this clinical trial is to evaluate the impact of inhaled Treprostinil on breathlessness and low exercise capacity in patients living with mild chronic obstructive pulmonary disease.
- Trial name
- NCT06969573
- Testing
- Treprostinil Inhalation Solution 36 mcg, Treprostinil Inhalation Solution 78 mcg
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease (COPD), Dyspnoea
Sports Shoes and the Six-Minute Walk Test in COPD
COPD: A Leading Cause of Respiratory Disability COPD, primarily linked to smoking, affects 3.5 million people in France and causes 15,000 deaths each year.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Dyspnoea, Exercise Intolerance
- Trial name
- ChaussePnee (NCT07445750)
- Testing
- Active Sports Shoes, Usual Shoes
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes
Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program
This study was conducted to test the possibility of preventing or delaying the development of type 2 diabetes in individuals with impaired glucose tolerance and elevated fasting plasma glucose concentrations by internet-based…
- Trial name
- NCT01085682
- Testing
- Lifestyle counseling, Standard care
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea