Clinical trials: Exercise Intolerance
Diabetes, Pre-diabetes
Weight Loss and/or Exercise Training to Discover Muscle Lipids Related to Insulin Sensitivity
The investigators will use exercise training and weight loss to discover localized lipid species related to diabetes risk in people.
- Trial name
- NCT02043405
- Testing
- Weight loss and exercise training intervention, Weight loss Only Intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sedentary Lifestyle, Hyperinsulinemia
Developing a Physiological Understanding of High Duration Activity
When muscles are not contracting, the local energy demand by muscle and use of specific fuels used to produce energy by oxidative metabolism are minimal.
- Conditions
- Sedentary Lifestyle, Hyperinsulinemia, Glucose Tolerance Impaired, Low-density-lipoprotein-type
- Trial name
- NCT05135234
- Testing
- Muscular Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Houston
Gestational Diabetes, PreDiabetes
Maternal Health Diabetes Prevention Study
The aim of this project is to use the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to collect pilot data on the implementation of a Diabetes Prevention Program-like intervention in the Women, Infants…
- Conditions
- Gestational Diabetes, PreDiabetes, Hyperglycemia, Glucose Intolerance During Pregnancy
- Trial name
- NCT05343494
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tulane University
Post-Exercise Hypotension
Resistance Exercise Modify Cardiovascular Responses of Professors During Teaching and Sleep
Both work activity and reduced nocturnal dipping of blood pressure are related to increased cardiovascular risk. The aim of the present study was to assess the hemodynamic and autonomic responses of university professors during…
- Trial name
- NCT02650089
- Testing
- Resistance Exercise Low intensity, Resistance Exercise High intensity, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Obesity, Diabetes Mellitus
Type 2 Diabetes Primary Prevention for At Risk Girls
Purpose: To evaluate two approaches to prevent obesity and type 2 diabetes in young girls. The Need: We are experiencing an epidemic of childhood obesity.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- NCT00063674
- Testing
- Nutrition Education, After-school dance class
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Heart Failure With Preserved Ejection Fraction, Obesity
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity.
- Trial name
- NCT05723679
- Testing
- HeO2 gas mixture, Room air gas mixture
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging, Cardiovascular Diseases
Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population
Physical inactivity is known to increase post meal blood sugar levels in young, active populations. However, how quickly this may occur in active, older adults is not clear.
- Conditions
- Aging, Cardiovascular Diseases, Glucose Intolerance
- Trial name
- NCT04812392
- Testing
- Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leryn Reynolds
Menopause, Physical Activity
Response to Aerobic Training in Postmenopausal Women With Exercise Intolerance.
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide and represent a major public health challenge, with growing evidence highlighting important sex-related differences in their…
- Conditions
- Menopause, Physical Activity, Prevention, Cardiovascular (CV) Risk
- Trial name
- WOMEN-EX-IC (NCT07422961)
- Testing
- Training
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Sarcoidosis
Muscle Strength and Exercise Capacity in Sarcoidosis Patients
The aim of this study is to examine exercise capacity, muscle strength and fatigue in sarcoidosis. In this longitudinal study the changes in prevalence of exercise intolerance, reduced muscle strength and fatigue will be…
- Trial name
- NCT00854672
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Pregnancy Related, Diabetes
Exercise Timing and Gestational Diabetes
The aim of this study is to understand if the timing of exercise around food intake can help improve blood sugar management in pregnant individuals with diabetes.
- Conditions
- Pregnancy Related, Diabetes, Diabete Mellitus, Type 2 Diabetes
- Trial name
- NCT05256615
- Testing
- 30-minute walking intervention, 10-minute
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Idiopathic Pulmonary Fibrosis
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).
Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease marked by reduced exercise capacity and activity-related breathlessness (commonly termed dyspnea).
- Trial name
- NCT05052229
- Testing
- Nitric Oxide, Medical air
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Heart Failure With Normal Ejection Fraction
Exercise Intolerance in Heart Failure
The investigators are studying whether metabolic abnormalities in cardiac and skeletal muscle in patients with heart failure with preserved ejection fraction (HFpEF) are associated with debilitating exercise intolerance.
- Trial name
- NCT03775577
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
PreDiabetes, Pre Diabetes
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Trial name
- NCT07713030
- Testing
- High-Intensity Interval Training, Continuous Endurance Training
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Healthy Women Volunteers
A Single Pole Dancing Session and Its Effects on Blood Pressure
This study aimed to evaluate the acute blood pressure (BP) response after a single pole dance (PD) session in adult women. Twenty-one young women (<31 years old) with normal BP and previous PD experience participated.
- Trial name
- NCT07590258
- Testing
- Pole Dance
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Catarina
Obstructive Sleep Apnea
Exercise Intolerance in Obstructive Sleep Apnea Syndrome Patients
The syndrome of obstructive sleep apnea (OSAS) is a public health problem that affects 2 to 4% of the general population. The patients with OSAS frequently complain of intolerance to exercise muscle fatigue and a significant even…
- Trial name
- EXAOS (NCT00837018)
- Testing
- physical exercise program
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Fabry Disease, Fabry Disease, Cardiac Variant
Fabry Exercise Intolerance Study
Patients and healthy controls will undergo cardiopulmonary exercises and testing of the muscles strength to gain additional understanding of exercise intolerance as Fabry disease (FD) manifestation.
- Trial name
- FEISTY (NCT05413876)
- Testing
- Intermittent cardiopulmonary exercise test, Incremental cardiopulmonary exercise test
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs