Clinical trials: Exercise Intolerance
Fabry Disease, Fabry Disease, Cardiac Variant
Fabry Exercise Intolerance Study
Patients and healthy controls will undergo cardiopulmonary exercises and testing of the muscles strength to gain additional understanding of exercise intolerance as Fabry disease (FD) manifestation.
- Trial name
- FEISTY (NCT05413876)
- Testing
- Intermittent cardiopulmonary exercise test, Incremental cardiopulmonary exercise test
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heat Intolerance, Heat Stress
Acquiring and Targeting Heat Exposures Necessary for Action
The purpose of this research study is to better understand ways that women and men differ physiologically, cognitively, physically, and cellularly to better prescribe helpful interventions that will prevent injury and risk of…
- Conditions
- Heat Intolerance, Heat Stress, Fatigue; Heat
- Trial name
- ATHENA (NCT05678738)
- Testing
- Antioxidant Berry Supplementation, Acute and Chronic Exercise-Heat Stress
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Type 2 Diabetes
Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program
This study was conducted to test the possibility of preventing or delaying the development of type 2 diabetes in individuals with impaired glucose tolerance and elevated fasting plasma glucose concentrations by internet-based…
- Trial name
- NCT01085682
- Testing
- Lifestyle counseling, Standard care
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial
Exercise-meal Timing and Postprandial Glucose Control
Physical activity helps maintain optimal postprandial blood glucose control. However, there is a lack of clear information regarding the optimal meal-activity timing required to maximize blood glucose control.
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial, Physical Activity, Glucose Intolerance
- Trial name
- NCT03730727
- Testing
- Physical activity, Meal
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Beta Thalassemia Transfusion Dependent
Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD
The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects.
- Trial name
- THALEX (NCT07207577)
- Testing
- Maximal incremental exercise test
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Diabetes, Pre-diabetes
Weight Loss and/or Exercise Training to Discover Muscle Lipids Related to Insulin Sensitivity
The investigators will use exercise training and weight loss to discover localized lipid species related to diabetes risk in people.
- Trial name
- NCT02043405
- Testing
- Weight loss and exercise training intervention, Weight loss Only Intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Orthostatic Intolerance
Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading
As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up.
- Trial name
- Unload heart (NCT06939153)
- Testing
- LBNP, LBNP + Isometric handgrip exercise
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Tracy Baynard
Diabetes Prevention
Diabetes Prevention Program Pilot Study
This pilot study is intended to demonstrate that we can actually deliver the Diabetes Prevention Program intervention well and to show that it is likely effective.
- Trial name
- DPP (NCT00729079)
- Testing
- DPP
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Glucose Intolerance, Exercise
The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this…
- Conditions
- Glucose Intolerance, Exercise, Vascular Function
- Trial name
- NCT05468255
- Testing
- removal of exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Chronic Kidney Disease
Sympatholysis in Chronic Kidney Disease
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e.
- Trial name
- Sym-CKD (NCT02411773)
- Testing
- Sodium Bicarbonate, Exercise Training, Control to Exercise (Stretching)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Emory University
Pre-diabetes, Overweight and Obesity
Timing Exercise Training as Strategy to Improve Insulin Sensitivity and Substrate Metabolism in Men and Woman With Pre-diabetes
n a retrospective analysis of an exercise training program performed either in the morning or afternoon, we found that the afternoon training group improved their peripheral insulin sensitivity and fasting plasma glucose levels…
- Trial name
- Timed Training (NCT06014684)
- Testing
- Timing of exercise
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Covid19, Dyspnea
Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19
A novel corona virus emerged in 2019 causing Corona Virus Disease 2019 (covid-19). In one year more than 80 000 000 cases worldwide were documented.
- Trial name
- NCT04732663
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 2 Diabetes, Impaired Glucose Tolerance
Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons
A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity.
- Trial name
- SMIDIG (NCT00852982)
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Insulin Resistance, Impaired Glucose Tolerance
Cassia Cinnamon for Glucose Uptake in Young Women
The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood…
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, Prediabetes
- Trial name
- NCT00951639
- Testing
- Cassia cinnamon, 50 minutes exercise, Cellulose Powder
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baylor University
Healthy Subject, Stage IA Breast Cancer
MRI and Cardio-Pulmonary Exercise Testing in Evaluating Exercise Intolerance in Patients With Stage I-III Breast Cancer After Chemotherapy Treatment
This pilot research trial studies magnetic resonance imaging (MRI) and cardio (heart)-pulmonary (lung) exercise testing in evaluating exercise intolerance in patients with stage I-III breast cancer after treatment with…
- Conditions
- Healthy Subject, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT02702830
- Testing
- Cardiopulmonary Exercise Testing, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post-Exercise Hypotension, Ambulatory Blood Pressure Monitoring
Exercise Timing on the Morning Blood Pressure Surge
The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults.
- Conditions
- Post-Exercise Hypotension, Ambulatory Blood Pressure Monitoring, High-intensity Interval Exercise
- Trial name
- NCT06702930
- Testing
- Morning high-intensity interval exercise, Evening high-intensity interval exercise
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Type 2 Diabetes, Muscular Atrophy
Exercise Training as an Intervention to Improve Muscle Function and Recovery Following Bed Rest in Older Adults With Type 2 Diabetes
The purpose of this research is to gather data on how exercise can help recovery of muscle mass, strength, and physical function after bedrest in older adults with pre-diabetes and type 2 diabetes.
- Conditions
- Type 2 Diabetes, Muscular Atrophy, Sedentary Behavior, Exercise
- Trial name
- RECOVER (NCT04057677)
- Testing
- Bed Rest Intervention, Exercise Program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Sedentary Lifestyle, Physical Activity
A Mobile Based Diabetes Prevention Program
The goals of the study are to: 1. Assess effect sizes of our mDPP intervention on weight loss, physical activity, dietary intake, and fasting plasma glucose (FPG) levels from baseline to 5 months as compared to a control group.
- Conditions
- Sedentary Lifestyle, Physical Activity, Pre-Diabetic
- Trial name
- NCT01579292
- Testing
- Mobile phone based physical activity with intervention, Pedometer Only
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glucose Response, Blood Pressure
Effects of Meal and Exercise Sequence on Glucose and Blood Pressure Responses
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism.
- Trial name
- NCT06949683
- Testing
- Meal-Exercise, Exercise-Meal
- Where
- Taiwan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon