Clinical trials: Executive Function
Aging
Using TMS to Increase Executive Function in Older Adults
Cognitive decline and dementia have become important public health issues in our time as medical science has increased lifespan and our society becomes progressively older.
- Trial name
- WMTMS (NCT02767323)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression
Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression
This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression.
- Trial name
- NCT00602290
- Testing
- Citalopram, Methylphenidate (MPH)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of California, Los Angeles
Chronic Kidney Disease
Exercise Trial in Chronic Kidney Disease
Chronic Kidney Disease (CKD) is exceedingly common in older adults, in whom it is associated with impairment in cognition and physical function.
- Trial name
- AWARD (NCT01462097)
- Testing
- Aerobic exercise training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- University of Maryland, Baltimore
Aging
Aerobic Exercise to Improve Executive Language Function In Older Adults
The purpose of this study is to see if exercise can improve brain function in older adults
- Trial name
- NCT00979069
- Testing
- Aerobic group
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizoaffective Disorder
Antipsychotic Effects on Brain Function in Schizophrenia
The purpose of the study is to determine whether two commonly-prescribed antipsychotic medications (aripiprazole and risperidone) have different effects on brain function and cognition in schizophrenia patients.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- APD (NCT01913327)
- Testing
- Aripiprazole, Risperidone, Modafinil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Phenylketonuria
Phase 2 Study of Glycomacropeptide Versus Amino Acid Diet for Management of Phenylketonuria
For individuals with Phenylketonuria (PKU), the investigators hypothesize that glycomacropeptide will provide an acceptable form of low-phenylalanine dietary protein that will improve dietary compliance, blood phenylalanine…
- Trial name
- PKU (NCT01428258)
- Testing
- GMP Diet/GMP Medical Foods, AA Diet/AA Medical Foods
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Executive Function
Theta Connectivity in Working Memory
The participants will perform a cognitive control task. During the task, rhythmic trains of transcranial magnetic stimulation will be delivered to the prefrontal cortex and parietal cortex.
- Trial name
- STAR (NCT05204381)
- Testing
- Theta-frequency near-zero phase lag stimulation, Theta-frequency anti-synchrony stimulation, Arrhythmic near-zero phase lag stimulation
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Overweight and Obesity, Physical Activity
Implementation and Evaluation of a Before School Physical Activity Program in Revere, MA
This study evaluates the implementation of the BOKS program in three schools (K-8) in Revere, MA, and its effect on participating students with regard to BMI, cognitive, and quality of life outcomes.
- Conditions
- Overweight and Obesity, Physical Activity, Quality of Life, Fitness
- Trial name
- NCT03805295
- Testing
- BOKS Program
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorders
Gaming for Autism to Mold Executive Skills Project
The goal of the project is to better understand executive control-how children manage complex or conflicting information in the service of a goal.
- Trial name
- GAMES (NCT02361762)
- Testing
- Computerized executive control training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Interventional, controlled clinical trial with two arms, 110 Veterans with TBI and PTSD
- Trial name
- COMPASS (NCT01816061)
- Testing
- Experimental - COMPASS, Control - COMPASS
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Executive Function
Modulation of Cognitive Control Signals in Prefrontal Cortex by Rhythmic Transcranial Magnetic Stimulation
Purpose: In this study, the investigators will provide causal evidence for the role of alpha and theta oscillations in cognitive control.
- Trial name
- NCT03828734
- Testing
- Theta TMS, Alpha TMS, Arrhythmic TMS
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Behavior, Health
Train Your Brain: A Pilot Project to Improve Memory and Decision Making
The goal of this clinical trial is to pilot a computer-based working memory training program to improve delay discounting (DD) and prevent substance use among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT05879198
- Testing
- Computer-based Intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Henry Ford Health System
Attention Deficit Hyperactivity Disorder (ADHD)
Integrated Brain, Body and Social Intervention for Attention Deficit Hyperactivity Disorder (ADHD)
The investigators are conducting this randomized trial to determine if IBBS (Integrated Brain, Body, and Social)intervention is an effective treatment for ADHD (attention Deficit Hyperactivity Disorder) in two culturally distinct…
- Trial name
- IBBS (NCT01542528)
- Testing
- IBBS
- Where
- 5 sites in United States, China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Yale University
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Phenylketonuria
A Phase 3 Substudy to Evaluate Executive Function in Adults With PKU Who Are Participating in the Phase 3 Study, 165-302
A Phase 3 substudy to evaluate executive function in adults with phenylketonuria who are participating in the phase 3 Study, 165-302. Approximately 100 subjects, aged ≥ 18 to ≤ 70 years old, with PKU will be enrolled.
- Trial name
- PRISM303 (NCT02468570)
- Testing
- Administration of CANTAB and Subject Global Assessment
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- BioMarin Pharmaceutical