Clinical trials: Exacerbation of COPD
Pulmonary Disease, Chronic Obstructive
Exploratory Study of Xolair in Chronic Obstructive Pulmonary Disease in Patients With Elevated IgE Levels
The objective is to conduct an exploratory study on the effect of Omalizumab on COPD patients with elevated IgE. Exploratory outcomes include to determine whether Omalizumab use: reduces exacerbations in COPD patients; or…
- Trial name
- NCT00851370
- Testing
- Omalizumab (Xolair)
- Where
- United States
- Sponsor
- National Jewish Health
Chronic Obstructive Pulmonary Disease
Hyaluronic Acid in Acute Exacerbation of COPD - Duration Of Noninvasive Assistance
The objective of this study is to test the effect of High Molecular Weight Hyaluronic Acid (HMW-HA) on Non Invasive Ventilation (NIV) effectiveness in patients admitted to a sub-intensive care unit for respiratory failure due to…
- Trial name
- HAEC-DONA (NCT02674880)
- Testing
- HMW-HA
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Campus Bio-Medico University
Pulmonary Disease, Chronic Obstructive
Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess whether administration of a bolus dose of MgSO4 (magnesium sulfate) plus standard therapy is superior to standard therapy alone for the management of Acute Exacerbations of Chronic Pulmonary…
- Trial name
- NCT02498496
- Testing
- Magnesium Sulfate
- Sponsor
- Hôpital de Verdun
Chronic Obstructive Pulmonary Disease
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society.
- Trial name
- MORPHEUS I/IIa (NCT04427826)
- Testing
- Morphine hydrochloride
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Influenza, Human
Effectiveness of Xuanfei Jiangzhuo Decoction for Influenza-Induced AECOPD
The goal of this observational study is to learn if a traditional Chinese herbal medicine (Xuanfei Jiangzhuo Decoction) works to help older adults recover from a COPD flare-up caused by the flu (influenza virus).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Influenza, Human, Virus Diseases
- Trial name
- NCT07393685
- Testing
- Xuanfei Jiangzhuo Decoction, Standard Antiviral Therapy (Oseltamivir or Baloxavir marboxil)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University
COPD, Acute Exacerbation of COPD
Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD
The goal of this clinical trial is to learn whether a shorter course of antibiotics (7 days) works as well as the usual longer course (14 days) for adults admitted to hospital with a flare-up of chronic obstructive pulmonary…
- Trial name
- CDA (NCT07708337)
- Testing
- 7-day antibiotic course, 14-day antibiotic course
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- Capital Development Authority (CDA)
COPD Exacerbation
Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies
Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally.
- Trial name
- NCT05380375
- Where
- Tunisia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Monastir
COPD
Early Warning Value of Consumer Wearable Devices in AECOPD
This is a prospective, multi-center cohort study. 150 subjects with COPD and in stable stage will be included. Wearable device's physiological parameters will be continually collected, the investigators aim to explore whether…
- Trial name
- EWVCWDC (NCT05974670)
- Testing
- Consumer wearable device
- Where
- 7 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
COPD Exacerbation
Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Patients Presenting to the Emergency Department With Acute Exacerbation of COPD (ECOPD)
The primary aim is to determine whether nebulized Formoterol twice daily plus Revefenacin once daily is non-inferior to standard-of-care nebulized Albuterol and Ipratropium therapy four times daily in relieving dyspnea among…
- Trial name
- NCT07721922
- Testing
- Revefenacin, formoterol fumarate, Albuterol sulfate
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Chronic Obstructive Pulmonary Disease
Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital
Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of high prevalence and related disability and mortality (1).
- Trial name
- NCT06684353
- Volunteers
- 200 people
- Sponsor
- Sohag University
Acute Exacerbation Copd
Impact of Air Quality on Exacerbations of COPD in the Somme
All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie between 01/01/2017 and 31/12/2017.
- Trial name
- PolluBPCO (NCT03079661)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pulmonary Disease, Chronic Obstructive
Oscillating Positive Expiratory Pressure Devices and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Sputum production increases in acute exacerbation of COPD, both in amount and consistency. It increases airways obstruction and hence delays improvement and prolongs hospital stay.
- Trial name
- SIMPLE (NCT03299231)
- Testing
- OPEP Aerobika
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
COPD, COPD Exacerbation
Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate the prognostic role of echographic diaphragmatic assessment and vastus lateralis muscle ultrasound (US) in two independent populations of patients hospitalized for exacerbated Chronic…
- Trial name
- EDIFEB (NCT04509128)
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele Roma
Chronic Obstructive Pulmonary Disease
A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
- Trial name
- NCT01337661
- Where
- Ireland
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease (COPD)
2-arm Parallel Group Study of Fixed Combination of CHF 5993 vs Ultibro® in COPD Patients
The aim of the present study is to evaluate the superiority of the fixed triple therapy with BDP/FF/GB at a daily dose of 400/24/50 mcg respectively with that of Ultibro® Breezhaler® (DPI), fixed combination of indacaterol 85 mcg…
- Trial name
- TRIBUTE (NCT02579850)
- Testing
- Central spirometry, COPD assessment test, Local laboratory Assessments
- Where
- Italy
- Volunteers
- 1,532 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease
Effects of COPD Standardized Management on COPD Exacerbation
This is a multi-center, parallel-group,cluster randomised trial involving secondary hospitals across China. The objective is to evaluate the effect of COPD on reducing moderate-to-severe exacerbations during 12 months follow-up…
- Trial name
- COPD STANDARD (NCT04664491)
- Testing
- Standardized COPD management, Routine COPD management
- Where
- China
- Volunteers
- 3,456 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Post-hospitalisation Nutritional Support and Gait Speed in COPD
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT02261350
- Testing
- Food fortification, Oral Nutritional Supplements
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline