Clinical trials: Ethanol
Alcohol-Related Disorders, Alcohol Drinking
Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home
The purpose of this research study is to develop and test a care model to treat excessive drinking and alcohol use disorders in the primary care setting.
- Conditions
- Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
- Trial name
- NCT02885311
- Testing
- Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Abuse
CARES: A Mobile Health Program for Alcohol Risk Reduction
In this fast-track STTR, Phase 1 will develop and test a mobile phone app among 40 adult community college students. The app is designed to reduce risky drinking behaviors and improve user safety.
- Trial name
- NCT03927482
- Testing
- CARES mobile smart phone app, Check Your Drinking
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Alcohol Use Disorder
Theta Burst Stimulation for Alcohol Use Disorder
The study will examine the effects of two continuous theta burst stimulation (cTBS) sessions (given in a single day) on resting state functional MRI (fMRI), alcohol cue related attentional bias and alcohol craving in patients…
- Trial name
- NCT06060496
- Testing
- Active cTBS
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Gopalkumar Rakesh
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Alcoholism
Varenicline (Chantix™) for the Treatment of Alcohol Dependence
The purpose of this study is to determine the efficacy of varenicline (Chantix™) for the treatment of alcohol dependence.
- Trial name
- ChA (NCT00705523)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Substance Use Disorders, Alcohol Abuse
Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
The Contracts, Prompts, and Social Reinforcement (CPR) intervention was designed to address the continuing care adherence needs of veterans presenting for substance use disorder (SUD) treatment.
- Conditions
- Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence
- Trial name
- NCT00288886
- Testing
- Contracting, Prompting and Reinforcement arm, Control arm
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use, Unspecified
Behavioral Economic Treatment to Enhance Rural (BETTER) Living
The purpose of this trial is to get feedback to help develop programs delivered by phone and text messages to improve wellness and health behaviors.
- Trial name
- NCT05235971
- Testing
- Episodic Future thinking, Volitional choice, Monitoring only
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan
Alcoholism
Ketogenic Diet (KD) in Alcoholism
Background: A ketogenic diet (KD) is high in fat and low in carbohydrates. Research has shown that a KD can lessen tremor in animals withdrawing from alcohol.
- Trial name
- NCT03255031
- Testing
- Ketogenic Diet (KD), Standard American (SA) Meals and Shakes
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cardiovascular Disease (CVD), Hypertension
Veteran Peer Coaches Optimizing and Advancing Cardiac Health
The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor.
- Conditions
- Cardiovascular Disease (CVD), Hypertension, Hyperlipemia, Obesity
- Trial name
- Vet-COACH (NCT02697422)
- Testing
- Community-based peer health coach intervention
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Surgical Site Infection
Chlorhexidine-Alcohol Versus Povidone-Iodine for Cesarean Antisepsis
Primary Hypothesis: chlorhexidine gluconate alcohol skin antiseptic preparation is superior to povidone-iodine scrub and paint skin antiseptic preparation for prevention of cesarean related surgical site infection.
- Trial name
- CAPICA (NCT02202577)
- Testing
- Chlorhexidine - Isopropyl alcohol, Povidone-Iodine Scrub and Paint
- Where
- United States
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Alcohol, Drinking, Alcohol Use Disorder
Sustaining Patient-centered Alcohol-related Care
Alcohol use is the third greatest cause of disability and death for US adults. Care for unhealthy alcohol use is lacking in most primary care settings.
- Trial name
- SPARC (NCT02675777)
- Testing
- Quality Improvement Intervention
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Binge Drinking
An Open Label Trial of Bupropion and Naltrexone for Binge Drinking
This is an open-label Phase IIa pilot study of the tolerability and effects on binge drinking of bupropion and naltrexone for binge drinkers.
- Trial name
- NCT02842073
- Testing
- Naltrexone, Bupropion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Drinking
Feasibility and Effectiveness of a Specialized Brief Intervention for Hazardous Drinkers in an Emergency Department.
Alcohol use and its consequences represent an important public health problem. As well as alcohol dependence, hazardous drinking also contributes to a high burden in terms of morbidity and mortality.
- Trial name
- PPAU (NCT03273283)
- Testing
- Brief Intervention
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Chronic Pancreatitis, Genetic Mutation
An Observational Study on the Natural Course of Chronic Pancreatitis
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
- Conditions
- Chronic Pancreatitis, Genetic Mutation, Smoking, Tobacco, Drinking, Alcohol
- Trial name
- NCT04574297
- Testing
- smoking and alcohol assumption, genetic sequencing
- Volunteers
- 798 people
- Sponsor
- Changhai Hospital
Acute Pancreatitis (AP), Gallstone Pancreatitis
Pentoxifylline Treatment in Acute Pancreatitis (AP)
The purpose of this study was to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis.
- Conditions
- Acute Pancreatitis (AP), Gallstone Pancreatitis, Alcoholic Pancreatitis, Trauma Acute Pancreatitis
- Trial name
- AP (NCT02487225)
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mayo Clinic
Alcohol Dependence, Problem Drinking
Alcohol Pharmacotherapy for HIV+ Prisoners
This is a randomized controlled trial of injectable intramuscular naltrexone (XR-NTX) versus intramuscular placebo among HIV-infected prisoners meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition…
- Conditions
- Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus
- Trial name
- INSPIRE (NCT01077310)
- Testing
- Vivitrol- Intramuscular naltrexone (depot-formulation)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Alcohol Consumption, Unsafe Sex
Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk
This brief alcohol and sexual risk taking intervention has the potential to influence the public health by reducing alcohol use and sexual risk taking behavior in individuals who are seeking treatment in an Emergency Department.
- Trial name
- SAFER (NCT01351389)
- Testing
- Brief Motivational Intervention (BMI), Brief Advice
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brown University
Insomnia
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & Relapse
Insomnia is a highly prevalent disorder in those recovering from alcoholism. It has been associated with anxiety and depressive symptoms, as well as an increased risk of relapse back to the drinking.
- Trial name
- NCT01987089
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Alcohol Withdrawal
Phenobarbital for Acute Alcohol Withdrawal
Intravenous phenobarbital in combination with a symptom-guided standardized lorazepam-based alcohol withdrawal protocol will be associated with decreased need for ICU admission, continuous lorazepam infusion and will not be…
- Trial name
- NCT01184417
- Testing
- 10 mg/kg IV phenobarbital in 100 ml saline
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Jonathan Rosenson