Clinical trials: Essential Hypertension
Essential Hypertension
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
Children are increasingly being diagnosed with essential hypertension and the absence of comparative effectiveness research in antihypertensive therapies has contributed to considerable differences in prescribing practices among…
- Trial name
- NCT02412761
- Testing
- Lisinopril, Amlodipine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The University of Texas Health Science Center, Houston
Essential Hypertension
Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension
This study is designed to compare the safety and efficacy of levamlodipine besylate (2.5mg or 5mg) versus amlodipine maleate (5mg) in patients with mild to moderate essential hypertension.
- Trial name
- NCT01131546
- Testing
- Levamlodipine besylate, Amlodipine maleate
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Essential Hypertension
Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension
The purpose of this study is to explore the efficacy and safety of remote ischemic conditioning for essential hypertension in the community population.
- Trial name
- NCT03945305
- Testing
- Patients are treated with previous antihypertensive treatment plus remote ischemic conditioning., Previous antihypertensive treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Yi Yang
Diabetes Mellitus, Essential Hypertension
Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy
Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy.
- Conditions
- Diabetes Mellitus, Essential Hypertension, Renal Failure
- Trial name
- NCT00295555
- Testing
- Effects of doxazosin on morning surge in diabetic patients
- Where
- Japan
- Volunteers
- 98 people
- Sponsor
- Yokohama City University Medical Center
Essential Arterial Hypertension
Efficacy and Safety of Candesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control
The purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drug associations in the essential hypertension control.
- Trial name
- NCT02521233
- Testing
- Candesartan + Chlorthalidone (8mg+12,5mg), Candesartan + Chlorthalidone (8 mg + 25 mg), losartan+hydrochlorothiazide
- Sponsor
- EMS
Hypertension, Hypertension, Essential
Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension
The purpose of this study is to better understand the cardiovascular effects of the vasodilatory peptide Angiotensin (1-7) in human hypertension.
- Trial name
- NCT02245230
- Testing
- Angiotensin (1-7), Trimethaphan, Phenylephrine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University
Essential Hypertension
The Effects of Social Support and Oxytocin Administration on Physiological Stress Reactivity in Essential Hypertension
To test a psychopharmacological intervention strategy which may provide new insights into the mechanisms underlying the physiological hyperreactivity to stress observed in hypertension, we plan to test the effects of the…
- Trial name
- NCT01938911
- Testing
- Syntocinon-Spray, Social support
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Essential Hypertension
NW Roselle in Grade 1 Essential Hypertension: Phase III Clinical Trial
In this Phase III clinical trial, researchers evaluate the efficacy and safety of NW Roselle®, a powdered medicinal product developed by Natural Wellness.
- Trial name
- NCT06141200
- Testing
- NW Roselle, Captopril 25Mg Tab
- Volunteers
- 286 people
- Sponsor
- Natural Wellness Egypt
Hypertension
Efficacy and Safety of Azilsartan Medoxomil in Participants With Essential Hypertension
The purpose of this study is to determine the safety and efficacy of azilsartan medoxomil, once daily (QD), compared to placebo and olmesartan in participants with essential hypertension.
- Trial name
- NCT00696241
- Testing
- Azilsartan medoxomil and olmesartan, Olmesartan
- Where
- 85 sites in United States, Argentina and 1 more
- Volunteers
- 1,275 people
- Sponsor
- Takeda
Essential Hypertension, Type 2 Diabetes
Sacubitril/Valsartan Treats Patients With Essential Hypertension and Type 2 Diabetic Nephropathy
This study aims to compare the efficacy and safety of Sacubitril/Valsartan versus Valsartan in patients with essential hypertension and type 2 diabetic nephropathy over a 12-week treatment period, including two treatment groups…
- Conditions
- Essential Hypertension, Type 2 Diabetes, Nephropathy
- Trial name
- Hyper-Save (NCT06501651)
- Testing
- Sacubitril/Valsartan, Valsartan
- Where
- China
- Volunteers
- 297 people
- Sponsor
- Sichuan Academy of Medical Sciences
Essential Hypertension, Motivational Interview
Effect of Motivational Interviews on Cardiovascular Disease Risks and Healthy Lifestyle Behavior Changes
The primary aim of this study is to determine the effects of education and motivational interviews structured according to the health belief model on cardiovascular disease risks and healthy lifestyle behavior changes in patients…
- Conditions
- Essential Hypertension, Motivational Interview, Cardiovascular Disease Risk, Healthy Lifestyle Behavior
- Trial name
- NCT05390931
- Testing
- 6-session motivational interviews, Health education structured according to the health belief model, Training booklet prepared by the researchers on healthy lifestyle behavior changes
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Eskisehir Osmangazi University
Hypertension
Long Term Safety of Aliskiren Alone or With the Optional Addition of Hydrochlorothiazide in Patients With Essential Hypertension
Assess the long-term safety and tolerability of aliskiren, with the optional addition of HCTZ, in patients with essential hypertension, to ensure long term blood pressure control and protect against end organ damage.
- Trial name
- NCT00219037
- Testing
- aliskiren
- Where
- Germany
- Volunteers
- 1,955 people
- Sponsor
- Novartis
Hypertension,Essential, Hypertension
Effect of Isometric and Aerobic Physical Exercise on Blood Pressure Levels in Hypertensive Elderly People
Introduction: Adequate blood pressure control is necessary to reduce the risk of mortality from cardiovascular events. The effects of aerobic exercise on systemic arterial hypertension are already well known, however, to date…
- Trial name
- NCT06282302
- Testing
- Group control, Isometric Exercise, Aerobic Exercise
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Essential Hypertension
Feasibility Study Evaluating the Safety and Efficacy of the Renal Stimulation by Direct Wire Pacing, During Renal Denervation Procedure
The goal of this feasibility study is to evaluate the safety and efficacy of the Renal Stimulation (RNS) by Direct Wire Pacing, during Renal Denervation (RDN) procedure in patient candidate for renal denervation with the…
- Trial name
- RNS by DWP (NCT06235554)
- Testing
- Renal Stimulation
- Volunteers
- 10 people
- Sponsor
- Ceric Sàrl
High Blood Pressure (& [Essential Hypertension]), Motivation for Physical Activity
Instructor Interpersonal Behaviours in Classical Pilates as a Pathway to Improve Blood Pressure Control and Well-being in Hypertensive Adults
The aim of this study is to investigate, during a Classical Pilates programme with participants suffering from high blood pressure, whether supportive communication from the instructor to the participant has any effect on the…
- Conditions
- High Blood Pressure (& [Essential Hypertension]), Motivation for Physical Activity, Pilates Method, Interpersonal Communication Competence
- Trial name
- NCT07860437
- Testing
- Self-Determination Theory Based Supportive Communication, Control
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Instituto Politécnico de Leiria
Hypertension
A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal.
To compare the aliskiren regimen versus the ramipril regimen on reduction in Blood Pressure.
- Trial name
- NCT00219063
- Testing
- aliskiren
- Where
- United States
- Volunteers
- 844 people
- Sponsor
- Novartis
Hypertension, Renal
RENABLATE Feasibility Study CS156 (EC12-02) Study of Catheter Based Renal Denervation to Treat Resistant Hypertension
The RENABLATE feasibility study is a prospective, multi-center, non-randomized feasibility study to evaluate the safety and effectiveness of the investigational multi-electrode ablation catheter and integrated ablation system to…
- Trial name
- NCT01756300
- Testing
- Celsius® ThermoCool® RD
- Volunteers
- 35 people
- Sponsor
- Biosense Webster, Inc.
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Essential Hypertension
Treatment of HYpertension: Morning Versus Evening
Rationale: The nocturnal blood pressure mean is an independent and stronger predictor of cardiovascular disease (CVD) risk than either daytime office, awake or 24hour mean blood pressure.
- Trial name
- THYME (NCT02214498)
- Testing
- Enalapril/hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Erasmus Medical Center
Type 2 Diabetes Mellitus, Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1019" and Co-administration of "BR1019-1" and "BR1019-2"
The objective of this clinical study is to evaluate the pharmacokinetics and the safety after administration of "BR1019" and co-administration of "BR1019-1" and "BR1019-2" in healthy volunteers
- Trial name
- NCT06226727
- Testing
- BR1019, BR1019-1, BR1019-2
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd