Clinical trials: Essential Hypertension, open to volunteers
Diabetic Retinopathy, Retinal Vein Occlusion
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in…
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Hypertension,Essential, Retinal Vascular Disorder
- Trial name
- OCTA-RVD (NCT04505618)
- Testing
- Swept-Source (SS) OCT Angiography, Spectral-Domain (SD) OCT Angiography, Fundus Imaging
- Where
- United States
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-3 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-3 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421414
- Testing
- BR1015-A, BR1015-3, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Primary Hypertension
Bioequivalence Study of Sacubitril Alisartan Amlodipine Tablets
This study aims to evaluate the bioequivalence and safety of single oral administration of Sacubitril/Valsartan/Amlodipine Tablets (240mg/5mg) versus Sacubitril/Valsartan Calcium Tablets (240mg) combined with Amlodipine Besylate…
- Trial name
- NCT07486453
- Testing
- Sequence A T-R-T-R, Sequence B R-T-R-T
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-1 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421388
- Testing
- BR1015-A, BR1015-1, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Pulmonary Hypertension, Metal Poison
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients
Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls.
- Trial name
- NCT04756076
- Testing
- Metal level measurements
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Jiapeng Huang
Anxiety Disorders and Symptoms, Fibromyalgia
The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Herbal Medicine is known as the medicinal use of herbal substances as a means of treating different conditions in the human body to ensure that the body remains in optimal health and wellness.
- Conditions
- Anxiety Disorders and Symptoms, Fibromyalgia, Arthritis, Chronic Pain
- Trial name
- NCT05067998
- Testing
- IV Vitamin Infused Therapy Treatment, Herbal medicine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Faith A. Richardson
Healthy Volunteers Essential Hypertension
Study of KK3910 in Healthy Volunteers and Patients With Essential Hypertension
Part 1 : To evaluate the safety of single-dose KK3910 in healthy volunteers. Part 2 : To evaluate the safety of multiple-dose KK3910 in patients with essential hypertension.
- Trial name
- NCT06823947
- Testing
- KK3910
- Where
- 3 sites in Japan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Essential Hypertension, Healthy Volunteers
Phase 1 Clinical Study of MWX401 Injection in Chinese Healthy Participants and Participants With Mild Hypertension
This is a single-center, randomized, double-blind, placebo-controlled, single ascending-dose phase 1 clinical study, aimed at evaluating the safety, tolerability, PK, PD and immunogenicity of single subcutaneous administration of…
- Trial name
- NCT07803835
- Testing
- MWX401 1, MWX401 2, MWX401 3
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Healthy Individuals (Controls), PRIMARY HYPERTENSION PATIENT
The Effect of Motivational Interviewing on Knowledge, Self-Efficacy, and Treatment Adherence in Patients With Primary Hypertension Living in Semi-Rural Areas
This study is a single-center, single-blind, parallel-group randomized controlled trial designed to examine the impact of a Health Belief Model (HBM)-based motivational interviewing (MI) intervention on knowledge level…
- Trial name
- NCT07307924
- Testing
- Motivasyonel görüşme
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-3 and BR1015-2 Under Fasting Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-3 and BR1015-2 in healthy volunteers under fasting conditions
- Trial name
- NCT07421401
- Testing
- BR1015-A, BR1015-3, BR1015-2
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Primary Hypertension
Automatic and Conventional Methods of Hypertensive Patients Monitoring
comparing automatic blood pressure measurments methods with conventional office methods in follow up and monitoring of hypertensive patients and predicting hypertension mediated organ damage .
- Trial name
- NCT06929728
- Testing
- blood pressure measurments devices
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Assiut University
Uncontrolled Hypertension
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of single and multiple ascending doses of QLS1410 in healthy Chinese adults and participants with mild…
- Trial name
- NCT07152444
- Testing
- QLS1410 (CYP11B2 inhibitor)
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Atherosclerosis Cardiovascular Disease
Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension
Background: Hypertension (HT) is the most common condition worldwide, predisposing to atherosclerotic disease. However, most HT patients have suboptimal BP control despite anti-HT medications.
- Trial name
- IRE-HT (NCT07665034)
- Testing
- Squatting Exercise, Stretching (Yoga) Exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hypertension, Endothelial Function
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and…
- Trial name
- HYPER-endoEV-a (NCT07728630)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-1 and BR1015-2 Under Fasting Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fasting conditions
- Trial name
- NCT07421375
- Testing
- BR1015-A, BR1015-1, BR1015-2
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Primary Hypertension
The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble
The investigators intend to find a noninvasive method for CB modulation therapy and find a simple and convenient indicator for assessing CB activity.
- Trial name
- NCT06116357
- Testing
- External Ultrasonic Micro-bubble
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jing Huang
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu