Clinical trials: Esmolol
Decrease in Heart Rate Below Baseline Value
Genetic Determinants of Hemodynamic Response to Esmolol
Beta 1 Adrenergic antagonists (beta blockers) have major role in the treatment of CHF, IHD and hypertension. However, there is large interindividual variability in the response to beta blockers.
- Trial name
- NCT01388036
- Testing
- esmolol
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Gall Stone Disease
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
Comparison of intraoperative infusion of lidocaine and esmolol in the postoperative requirement of opioid for postoperative pain management after laparoscopic cholecystectomy to decrease opioid related side effects and enhance…
- Trial name
- NCT02327923
- Testing
- Lidocaine, Esmolol, Paracetamol
- Where
- Nepal
- Volunteers
- 90 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Deviation Septum Nasal
A Comparison of Esmolol and Remifentanil to Reduce Blood Loss
In this prospective randomized study we aimed to compare the effects of esmolol and remifentanil on intraoperative bleeding surgical field conditions in nasal surgery
- Trial name
- NCT01752959
- Testing
- Remifentanil, Esmolol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Septic Shock
Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia
This is a prospective, single arm, "roll-in" study of esmolol infusion for patients with septic shock with persistent tachycardia after adequate intravenous volume expansion.
- Trial name
- ECASSS-R (NCT02841241)
- Testing
- Esmolol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Intermountain Health Care, Inc.
Postoperative Pain
Dose Esmolol Infusion Have an Adjuvant Effect to TAP Block for Pain Control in Laparoscopic Cholecystectomy.
Pain after laparoscopy differs considerably from that seen after laparotomy. Laparotomy results mainly in parietal pain (abdominal wall), where as Pain in laparoscopy results from stretching of the intra-abdominal cavity…
- Trial name
- NCT04752111
- Testing
- Esmolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Healthy Volunteers, Pharmacokinetics/Dynamics Study
A Short Term Pharmacokinetic, Pharmacodynamic and Tolerability Study to Compare AOP200704 vs. Esmolol
Pharmacokinetics, pharmacodynamics and tolerability of AOP200704 infusion is compared to that of Esmolol by measurement of plasma concentrations of AOP200704, esmolol and their metabolites, by assessing the effect of both drugs…
- Trial name
- NCT01313143
- Testing
- AOP200704, Esmolol hydrochloride, infusion
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AOP Orphan Pharmaceuticals AG
Myocardial Reperfusion Injury
Concomitant Milrinone and Esmolol Treatment in Patients with Acute Myocardial Infarction
Heart attack is the leading cause of death in the developed world. Following heart attack, re-establishing blood flow in a clogged heart vessel using percutaneous coronary intervention (PCI) is the standard of care.
- Trial name
- COMET-AMI (NCT02098629)
- Testing
- Milrinone, Esmolol, Saline Infusion
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Shantou University Medical College
Cerebral Arterial Disease, Cerebral Aneurysm
Esmolol Infusion in Patients Undergoing Craniotomy
Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative…
- Trial name
- NCT02455440
- Testing
- Esmolol, Propofol and sevoflurane
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Intubation Complication
Comparison of Hemodynamic Changes With Morphine Versus Esmolol During Induction of Anaesthesia
Comparing hemodynamic changes with morphine versus esmolol as an adjuvant agent during induction of Anaesthesia
- Trial name
- NCT06065956
- Testing
- Intravenous morphine
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Pakistan Navy Station Shifa Hospital
Injection Site Irritation, Pain
Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
The primary hypothesis is that esmolol and lidocaine, when given without the use of a tourniquet, provide relief of propofol injection pain that is superior to placebo when assessed using the propofol pain scoring tool
- Trial name
- NCT04356352
- Testing
- Lidocaine, Esmolol
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Myocardial Infarction, Coronary Stenosis
Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI
Study rationale: to evaluate clinical and prognostic relevance of microvascular dysfunction, coronary flow reserve and cardioprotective effects of iv administration of esmolol in patients with myocardial infarction.
- Conditions
- Myocardial Infarction, Coronary Stenosis, Coronary Microvascular Dysfunction
- Trial name
- ESMO-VASCMI (NCT06376630)
- Testing
- Esmolol Hcl 10Mg/Ml Inj
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Anesthesia; Adverse Effect, Reflex, Abnormal
The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea
The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.
- Conditions
- Anesthesia; Adverse Effect, Reflex, Abnormal, Tinnitus, Spontaneous Oto-Acoustic Emission
- Trial name
- NCT02062333
- Testing
- Dexmedetomidine, esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- TC Erciyes University
Healthy
Long-term PK and Safety/Tolerability Testing LDLL600 Against Esmolol in Healthy Volunteers
The study will compare the pharmacokinetics (PK), safety and tolerability of long-term infusion of lyophilized landiolol (LDLL600) against esmolol (Brevibloc) by measurement of blood concentrations of landiolol, esmolol and their…
- Trial name
- NCT01741519
- Testing
- LDLL600, Brevibloc
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AOP Orphan Pharmaceuticals AG
Chronic Rhinosinusitis, Enhanced Recovery After Surgery
Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of chronic sinusitis, with the advantages of deep approach, light trauma, and less pain.
- Trial name
- NCT06457100
- Testing
- Esmolol Injection, Lidocaine IV
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second People's Hospital of Huai'an
Septic Shock
Esmolol Effects on Heart and Inflammation in Septic Shock
Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the inflammatory response. Experimental works demonstrated that Esmolol, an highly selective beta-1 blocker, reduces heart rate and regulates…
- Trial name
- ESMOSEPSIS (NCT02068287)
- Testing
- Esmolol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Opioid Use, Unspecified, Anesthesia
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal…
- Conditions
- Opioid Use, Unspecified, Anesthesia, Nociceptive Pain
- Trial name
- ESMONOL (NCT06291363)
- Testing
- Esmolol Hydrochloride, Saline
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Acute Respiratory Distress Syndrome
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome caused by intrapulmonary and/or extrapulmonary causes, characterized by intractable hypoxemia.
- Trial name
- NCT06013319
- Testing
- Esmolol
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Zhiming Jiang
Laparoscopic Surgery
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery.
- Trial name
- NCT01114971
- Testing
- Fentanyl, Labetalol, Esmolol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cedars-Sinai Medical Center
Aging
Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion
This study will test the central hypothesis that postmenopausal women will demonstrate increased oxygen extraction in active leg muscle during leg cycling exercise while receiving an infusion of Esmolol, a fast-acting β1…
- Trial name
- NCT04181606
- Testing
- Esmolol infusion, Saline infusion, Pre exercise baseline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David N. Proctor, PhD