Clinical trials: Eradication Therapy of Helicobacter Pylori
Helicobacter Pylori Infection, Non Ulcer Dyspepsia
Helicobacter Pylori Eradication With a New Sequential Treatment
Eradication rates of Helicobacter pylori (H. pylori) with standard triple therapy are disappointing, and studies from several countries confirm this poor performance.
- Conditions
- Helicobacter Pylori Infection, Non Ulcer Dyspepsia, Duodenal Ulcer, Gastric Ulcer
- Trial name
- NCT00132171
- Testing
- Sequential therapy
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infection
One vs Two Weeks Treatment for H.Pylori Eradication A RANDOMIZED NON-INFERIORITY PLACEBO CONTROLLED TRIAL
1. To assess the efficacy of the duration of Vonoprazan based triple regimen (one versus two weeks), in the eradication of H-pylori among patients attending gastroenterology clinics of Karachi, Pakistan. 2.
- Trial name
- NCT05728424
- Testing
- Vonoprazan, Amoxicillin, Levofloxacin
- Where
- Pakistan
- Volunteers
- 246 people
- Sponsor
- Aga Khan University
Helicobacter Pylori Infection, Dyspepsia
Control of Helicobacter Pylori Infection by Dietary Supplementation With Lactobacillus Reuteri
Helicobacter pylori colonizes approximately to 50% of the world-wide population. There is an exigency to find routes alternating to control the infection with an ample perspective but without the complications of induction of…
- Trial name
- NCT01028690
- Testing
- Lactobacillus reuteri
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Regional para el Estudio de las Enfermedades Digestivas
Helicobacter Pylori
The Study on the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT04810793
- Testing
- Amoxicillin , Levofloxacin and Esomeprazole, Amoxicillin , Furazolidone and Esomeprazole, Tetracycline , Furazolidone and Esomeprazole
- Where
- China
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Shandong University
HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residing in the gastric mucosa and using the mucus layer for protection from the stomach's high acidity.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected Patients
- Trial name
- NCT07293910
- Testing
- Vonoparazan, Vitamin D, Probiotic
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tanta University
Helicobacter Pylori Infection, Helicobacter Pylori Infected Patients
Study to Evaluate the Efficacy and Safety of DWP14012-based Triple Therapy in Eradication of Helicobacter Pylori
This study is designed to demonstrate the non-inferiority and verify the safety of DWP14012-based triple therapy compared to DWC202301-based triple therapy as the first-line eradication therapy in patients who are positive for…
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Infected Patients, Helicobacter Pylori Infected Subjects
- Trial name
- NCT06751121
- Testing
- DWP14012 40mg, DWC202301 30mg, Amoxicillin 1000mg
- Where
- South Korea
- Volunteers
- 461 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
H.Pylori Gastrointestinal Disease
Eradication Rate Between 1- and 2-Week Helicobacter Pylori Eradication Therapy
It is recommended as the first line treatment regimen to eradicate Helicobacter pylori (HP), 7 or 14 days treatment of proton pump inhibitor (PPI) based triple therapy consisting of one PPI and two antibiotics, clarithromycin and…
- Trial name
- NCT02487511
- Testing
- Duration of HP therapy
- Where
- South Korea
- Volunteers
- 387 people
- Sponsor
- St.Paul's Hospital, Korea
H. Pylori Infection
Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Background: Helicobacter pylori infection, which affects over 50% of the global population, is one of the most prevalent infectious diseases in the world. H.
- Trial name
- vDHp (NCT03142620)
- Testing
- Esomeprazole, Amoxicillin-Potassium Clavulanate Combination, Clarithromycin
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Helicobacter Pylori Infection
Comparison of the Effect of Helicobacter Pylori Eradication Before and After the Training of Gastroenterologists
The researchers recruited gastroenterologists. Physician subjects recruited Helicobacter pylori-positive patients before and after receiving standardized training on Helicobacter pylori eradication.
- Trial name
- NCT04984382
- Testing
- Standardized training on Helicobacter pylori eradication treatment
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
H. Pylori Infection
Eradication of H. Pylori Therapy Individualized by the Mutation of 23S rRNA of H. Pylori
Patients infected with H. pylori are treated with the individualized regimen which is based on the mutation of 23S rRNA of H. pylori.
- Trial name
- EHR (NCT02761005)
- Testing
- Eradication of H. pylori
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Hamamatsu University
Helicobacter Pylori Infection
Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children
This study aimed at comparing the efficacy of nitazoxanide-based triple therapy versus standard triple therapy for eradication of Helicobacter pylori infection in children at a tertiary care hospital.
- Trial name
- NCT07086937
- Testing
- Nitazoxanide, Metronidazole, PPI
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Muhammad Aamir Latif
Helicobacter Pylori Infection
Differences in the Eradication of Helicobacter Pylori by Different Therapies
To compare the performance of four treatment regimens for radical treatment of Helicobacter pylori, evaluating the efficacy, safety, patient compliance, and socioeconomic evaluation of the four regimens.
- Trial name
- NCT05097846
- Testing
- Group1 Vonoprazan Fumarate + amoxicillin + doxycycline, Group2 Vonoprazan Fumarate + furazolidone + doxycycline, Group3 esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- wang xiaoyan
Gut Resistome
Effect of Probiotics on the Fecal Resistome During Helicobacter Pylori Eradication Therapy
Eradication therapy against Helicobacter pylori (Hp) carries adverse effects, such as altering the intestinal microbiota's structure and function and selecting commensals and pathogens resistant to antibiotics.
- Trial name
- NCT04786938
- Testing
- Saccharomyces Boulardii-Containing Product in Oral Dose Form
- Volunteers
- 72 people
- Sponsor
- Universidad San Francisco de Quito
Helicobacter Pylori Infection
Rescue Therapy for Helicobacter Pylori Eradication Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT04531059
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Tetracycline,Metronidazole
- Where
- 3 sites in China
- Volunteers
- 368 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lymphoma, Lymphoma, Non-Hodgkin
Helicobacter - Lymphoma - Radiation Part I: Eradication, Part II: Radiation
The first objective of this study is to confirm the results of complete remission of low-grade gastric MALT lymphoma stage IE \& II1E after H. pylori eradication on a larger number of patients (HELYX Part I).
- Trial name
- NCT00154440
- Testing
- proton pump inhibitor, clarithromycin, amoxicillin
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Gastritis, Gastric Ulcer, and Duodenal Ulcer
Concomitant Therapy of H. Pylori
If we compare eradication rate of Helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(AOC), amoxicillin, rabeprazole, metronidazole(AOM), treated with amoxicillin, rabeprazole for 5 day, followed by…
- Trial name
- NCT01922765
- Testing
- amoxicillin, clarithromycin, metronidazole, rabeprazole
- Where
- South Korea
- Volunteers
- 540 people
- Sponsor
- The Catholic University of Korea
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection
The investigators will performed a large-scale multi center trial to compare the efficacy of a high-dose dual therapy (HDDT) with that of standard therapies in treatment-naive (n = 300) patients with Hp infection.
- Trial name
- HDDT (NCT02553083)
- Testing
- Nexium 40 mg, amoxicillin 1.5 gr, doxycycline 200 mg
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori
Optimized-dose Amoxicillin Versus Standard-dose Amoxicillin for Quadruple Therapy in Helicobacter Pylori Eradication
The goal of this prospective randomized clinical trial is to compare the rate of Helicobacter Pylori (HP) eradication after standard or dose-optimized amoxicillin quadritherapy in patients naïve to any anti-HP treatment and with…
- Trial name
- Helicomatri (NCT05635942)
- Testing
- optimized quadruple therapy, standard quadruple therapy
- Where
- Tunisia
- Volunteers
- 88 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Helicobacter Pylori Eradication Rate
Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori Infection
Eradication of HP can significantly improve and reduce HP-related diseases. A 10-14 day quadruple regimen containing bismuth as first-line treatment, achieving an eradication rate of more than 85%.
- Trial name
- NCT06734260
- Testing
- Keverprazan Hydrochloride tablets + high dose amoxicillin, Keverprazan Hydrochloride tablets + low dose amoxicillin, Keverprazan Hydrochloride tablets + high dose amoxicillin（H-KA-10d）
- Where
- 4 sites in China
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University