Clinical trials: Epilepsy Sleep
Epilepsy
Lily's Grace Temporal Interference
This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional…
- Trial name
- SLEEP-TIES (NCT07520955)
- Testing
- TES-TI, Structural and Functional MRI
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Rare Diseases, Autism or Autistic Traits
Baker Gordon Syndrome Natural History Study
The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome…
- Conditions
- Rare Diseases, Autism or Autistic Traits, Development Delay, SYT-SSX Fusion Protein Expression
- Trial name
- BAGOS (NCT06399952)
- Testing
- Brain Magnetic Resonance Imaging (MRI), Whole Genome Sequencing, Induced Pluripotential Stem Cells
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Alzheimer Disease, Early Onset
Epileptiform Activity During REM Sleep in Alzheimer's Disease
Recent clinical data showed that patients with Alzheimer Disease (AD) might present epilepsy at early stages of the disease (Cretin et al., 2016, Vossel et al., 2016).
- Trial name
- EREMAD (NCT03923569)
- Testing
- Overnight polysomnography, blood sample, high-resolution MRI scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Epilepsy, Seizures
Neural Circulatory Control and SUDEP Risk.
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP).
- Trial name
- NC-SUDEP (NCT02813980)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Benign Epilepsy With Centro Temporal Spikes (BECTS), Atypical Benign Partial Epilepsy (ABPE)
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike…
- Conditions
- Benign Epilepsy With Centro Temporal Spikes (BECTS), Atypical Benign Partial Epilepsy (ABPE), Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)
- Trial name
- EPIMEM (NCT03865771)
- Testing
- Neuropsychological testing, Neuropsychological procedure, Video EEG and polysomnography
- Where
- 2 sites in France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy Intractable
Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Epilepsy, a prevalent neurological disorder, affects 40% of patients with uncontrolled seizures despite medications. Sleep disturbance exacerbates epilepsy, and vice versa, but existing literature suffers from limitations.
- Trial name
- NCT06545643
- Testing
- Dreem headband
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Epilepsy, Cognitive Dysfunction
Investigation of the Effects of Pilates Training in Patients With Drug-Resistant Epilepsy
This study was planned to examine the effects of Pilates training in patients with drug-resistant epilepsy. It was planned to include 40 epilepsy patients in the study.
- Conditions
- Epilepsy, Cognitive Dysfunction, Seizures, Quality of Life
- Trial name
- NCT06754124
- Testing
- Pilates Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Epilepsy
Pilot Study of Melatonin and Epilepsy
The prevalence of epilepsy is 1% in the USA. About 30% of epilepsy patients eventually become refractory to medical treatment. Co morbid conditions are becoming as important as seizure control as these affect overall wellbeing.
- Trial name
- NCT00965575
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Electroencephalography, Child
Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
The aim of the study is to compare the effect of melatonin, given orally, dexmedetomidine, given intranasally, and dexmedetomidine given sublingually on sleep induction, sleep duration, their possible impact on vital functions…
- Conditions
- Electroencephalography, Child, Dexmedetomidine, Melatonin
- Trial name
- MeloDex (NCT04665453)
- Testing
- Electroencephalography, Monitoring of vital functions, Melatonin 0,1mg/kg oral syrup
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Epileptic Encephalopathy
Cannabidiol in Children With Refractory Epileptic Encephalopathy
This study will assess the safety and tolerability of a cannabidiol-enriched Cannabis Herbal Extract in a small group of children with refractory epileptic encephalopathy.
- Trial name
- CARE-E (NCT03024827)
- Testing
- CanniMed® 1:20
- Where
- 4 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Saskatchewan
Temporal Lobe Epilepsy
Closed Loop Auditory Stimulus in Sleep and epilepsY
This is a single-centre pilot study of a non-invasive auditory stimulation during sleep in participants with temporal lobe epilepsy.
- Trial name
- CLASSY (NCT05159609)
- Testing
- Closed loop auditory stimulus
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Cardiff and Vale University Health Board
Epileptic Children,Sleep Disturbances,Maladaptive Behaviors
Sleep Problems in Epileptic Children and Their Caregivers
The aim of this study is to investigate the frequency of sleep problems in epileptic children and their caregivers.
- Trial name
- NCT05191576
- Testing
- Children's sleep habits questionnaire (CSHQ)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ege University
Partial Epilepsy
Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy
Sleepiness and fatigue are the most common complaints of people with epilepsy and can have a negative impact on quality of life. Though unproven, these problems are often blamed on anti-seizure medications.
- Trial name
- NCT01190098
- Testing
- Lacosamide
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- The Cleveland Clinic
Pain, Sleep
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This prospective observational study aims to describe the effectiveness of MC on pain, epilepsy, sleep and /or anxiety/depression in a cohorts of patients authorized to use MC, using pre-defined, validated self assessment scales.
- Conditions
- Pain, Sleep, Anxiety, Depression
- Trial name
- MC-RWE (NCT04526093)
- Testing
- Medical Cannabis
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Patients With Drug-resistant Focal Epilepsy, SEEG as Part of Presurgical Evaluation
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure…
- Trial name
- EPIDREAM 3 (NCT07605858)
- Testing
- Direct Electric Stimulation (DES)
- Where
- 2 sites in United States, France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy
Sleep Intervention for Pediatric Epilepsy
The purpose of the study is to develop and evaluate a sleep intervention program for improving sleep and health in youth with epilepsy and their parents.
- Trial name
- NCT02514291
- Testing
- Sleep intervention
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Epilepsy in Children, Sleep Disorder
Advanced EEG Technology in Childhood Epilepsy
A lot of effort has already been put into the development of smaller, wearable and more user-friendly devices to monitor seizures in patients with epilepsy.
- Trial name
- PnP (NCT04584385)
- Testing
- EEG
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy; Seizure, Sleep
Earbud EEG Feasibility Study
The goal of this study is to characterize the ability of the NextSense ear-EEG device to detect pathologic electrographic signatures of epilepsy and physiologic signatures of sleep in subjects undergoing simultaneous inpatient…
- Trial name
- PRIME (NCT05257811)
- Testing
- NextSense EEG-enabled earbuds
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NextSense, Inc.