Clinical trials: Epilepsy Intractable
Epilepsy, Depressions, Refractory
Low Frequency TMS for Depression in Epilepsy
The purpose of this study is to determine if low-frequency transcranial magnetic stimulation (TMS) is safe and feasible for treating depressive symptoms in patients with epilepsy.
- Trial name
- LFTMS (NCT03105700)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Epilepsia Partialis Continua, Status Epilepticus
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Epilepsy
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) as a treatment for Epilepsia Partialis Continua (EPC) or refractory Status Epilepticus (SE), when standard clinical…
- Trial name
- NCT02560597
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Refractory Epilepsy
Intrathecal Autologous ADRC Treatment of Autoimmune Refractory Epilepsy
Refractory epilepsies caused by an autoimmune mechanisms lead in children to progressive neurodegeneration. Immunomodulation therapy is effective only in a half of such cases. New approaches are undertaken.
- Trial name
- EPIMSC (NCT03676569)
- Testing
- ADRC transplantation in autoimmune refractory epilepsy
- Volunteers
- 6 people
- Sponsor
- Mossakowski Medical Research Centre Polish Academy of Sciences
Epilepsies, Focal, Pediatrics
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities.
- Conditions
- Epilepsies, Focal, Pediatrics, Drug Resistant Epilepsy
- Trial name
- EPITRACT (NCT03268824)
- Testing
- Electroencephalogram (EEG), Diffusion Tensor imaging, Language assessment
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Seizures, Epilepsy
Efficacy of BGG492 in Individuals With Refractory Partial Seizures Undergoing Inpatient Evaluation for Epilepsy Surgery
This study will asses the safety and efficacy of BGG492 in reducing the seizure rate in therapy-refractory partial seizures.
- Trial name
- NCT00887861
- Testing
- Investigational new drug, company code: BGG492
- Where
- 6 sites in Germany
- Volunteers
- 37 people
- Sponsor
- Novartis
Epilepsy, Epilepsy (Treatment Refractory)
Risk Factors for Drug-Resistant Epilepsy in Children
This prospective cohort study evaluates clinical, electroencephalographic predictors of drug-resistant epilepsy in children. Predictive statistical and machine-learning models will be developed to facilitate early identification…
- Trial name
- PED-DRE (NCT07723287)
- Testing
- No Intervention: Observational Cohort
- Where
- Vietnam
- Volunteers
- 375 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Epilepsy Intractable
Comparison of the Effectiveness of the Outpatient Classical Ketogenic Diet and Modified Atkins Diet on Seizures Frequency, Nutritional Status and Some Biochemical Factors in Children and Adolescents With Intractable Epilepsy
Epilepsy is one of a common neurological disorder. Antiepileptic drugs (AEDs) are usually the primary treatment of epilepsy. However, almost 30% of patients do not respond to AEDs and other treatments including ketogenic diet…
- Trial name
- NCT03014752
- Testing
- Classical ketogenic diet, Modified Atkins diet
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tehran University of Medical Sciences
Medication Refractory Epilepsy Patients With Electrodes Already Implanted Based on Clinical Criteria for Standard Monitoring
Model-based Electrical Brain Stimulation
Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them.
- Trial name
- NCT05327387
- Testing
- model-based electrical brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Intractable Epilepsy, Glucose Transporter Type 1 Deficiency Syndrome
Evaluation of Keyo in Children With Epilepsy
To evaluate the tolerance, acceptability and compliance of Keyo in 20 subjects aged 3 years and over, with intractable epilepsy or Glut-1 DS on a KD.
- Conditions
- Intractable Epilepsy, Glucose Transporter Type 1 Deficiency Syndrome, Ketogenic Dieting
- Trial name
- Keyo (NCT02915211)
- Testing
- Keyo
- Where
- 2 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- Vitaflo International, Ltd
Intractable Epilepsy
Ketogenic Diet Drink Study
An evaluation of the tolerance, compliance, acceptability and safety of a nutritionally complete liquid feed for use as part of the ketogenic diet (KD) in children 8+ years, adolescents and adults with intractable epilepsy or…
- Trial name
- NCT03196271
- Testing
- Ketocal 2.5:1
- Where
- 9 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Nutricia UK Ltd
Epilepsy, Refractory
Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
- Trial name
- NeuroSeizure (NCT05254730)
- Testing
- macro-micro tetrodes for intracranial recording
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Adrien Peyrache
Mesial Temporal Lobe Epilepsy
Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)
The primary aim of the current proposal is to evaluate safety and tolerability, in terms of neuropsychological effects of low frequency electrical stimulation of the fornix (LFSF) in participants with medically-intractable Mesial…
- Trial name
- MTLE-DBS (NCT02383407)
- Testing
- Medtronic Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- George Washington University
Drug-resistant Epilepsy
Electrophysiologic Studies of Cognition in Epilepsy Patients
Interoception, or sensation from inside the body, is involved in a variety of clinical symptoms, such as tics, compulsions and negative mood.
- Trial name
- NCT05769634
- Testing
- Stereoelectroencephalography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Refractory Epilepsy, Neuromodulation
Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy.
- Trial name
- NCT07305311
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Drug Resistant Epilepsy
Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY
Sudden and unexpected death in epilepsy (SUDEP) has become a major issue for patients with epilepsy and their physicians. SUDEP is a nontraumatic and non-drowning death in patients with epilepsy, unrelated to a documented status…
- Trial name
- MIRESPILEPSY (NCT03419000)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Refractory Epilepsy
Voronistat in Pediatric Patients With Drug Resistant Epilepsy
The study evaluates the safety, tolerability, and efficacy of Vorinostat in addition to standard of care anti-epileptic drugs in pediatric patients with medically refractory epilepsy.
- Trial name
- NCT03894826
- Testing
- Vorinostat 100 MG
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Epilepsy, Partial Seizures
Efficacy and Safety of Levetiracetam in Partial Seizures Control, With or Without Secondary Generalization
The purpose of this study is to determine whether levetiracetam as adjunctive therapy is effective in the treatment of partial seizures, with or without secondary generalization, associated with refractory focal epilepsy.
- Trial name
- Mozart (NCT01392768)
- Testing
- Levetiracetam
- Volunteers
- 126 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Drug Resistant Epilepsy, Seizure
NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy
To evaluate the safety and efficacy of using NaviFUS™ system in patients with drug resistant epilepsy
- Conditions
- Drug Resistant Epilepsy, Seizure, Seizure Disorder, Epilepsy
- Trial name
- NCT04999046
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- NaviFUS Corporation
Dravet Syndrome
Stiripentol in Dravet Syndrome
The patient has failed all other available agents and has intractable epilepsy due to Dravet Syndrome. Stiripentol is highly efficacious in Dravet Syndrome.
- Trial name
- NCT01533506
- Testing
- stiripentol
- Where
- United States
- Sponsor
- Mayo Clinic