Clinical trials: Epilepsy
Epilepsy
Use of the Atkins Diet for Children With Intractable Epilepsy: A Comparison of Daily Carbohydrate Limits
This study is designed to further investigate the use of a modified Atkins diet for children with intractable, daily seizures. It is a follow-up to a study recently completed by our institution.
- Trial name
- NCT00181090
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Epilepsy
Levetiracetam for Benign Rolandic Epilepsy
This study is designed to test if the language problems commonly seen in children with benign rolandic epilepsy would improve by switching anticonvulsants to levetiracetam.
- Trial name
- NCT00181116
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Epilepsy, Mental Retardation
Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy
This is an open randomized controlled study in children with mental retardation and refractory epilepsy in which treatment with ketogenic diet (KD) is compared with treatment with the antiepileptic drug (AED), not tried by the…
- Trial name
- NCT00552526
- Testing
- Ketogenic diet, Antiepileptic drug (AED)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Epilepsy
Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development.
- Trial name
- NCT00851331
- Testing
- genome analyzes (genetic defects and pathophysiological mechanisms )
- Where
- 4 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy, Depression
fMRI Investigation of Depression in Patients With Epilepsy
Depression is very common in epilepsy. Depression is the strongest predictor of poor quality of life in patients with epilepsy. The biological basis for depression in epilepsy remains poorly understood.
- Trial name
- NCT00532376
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Epilepsy, Rolandic
HEAD-Study Optimizing the Treatment of Children With BECTS
The investigators hypothesize that Levetiracetam is as effective as Sulthiame in the treatment of children with BECTS. Patients entering the HEAD-Studie are either treated with Leveitracetam or Sulthiame over a 6 months period.
- Trial name
- HEAD (NCT00471744)
- Testing
- Treatment with levetiracetam or sulthiame over a six-month period.
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Schizophrenia, Schizoaffective Disorder
Donepezil Double Blind Trial for ECT Memory Disfunction
This is a double blind randomized investigation of donepezil for patients suffering from schizophrenia, undergoing ECT. Patients will be randomized to receive either donezepil or plasebo, in order to gauge whether donezepil has a…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT00465283
- Testing
- Donepezil
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- BeerYaakov Mental Health Center
Dissociative Seizures
Cognitive Behavioural Therapy in Dissociative Seizures
The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater…
- Trial name
- NCT00688727
- Testing
- CBT, Standard Care
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Epilepsy
Comparison of Immediate vs Gradual Switch to Divalproex in Adults With Intellectual Disability
The purpose of this study is to determine whether there is any difference in side effects experienced by individuals with intellectual disorders taking Depakote DR (immediate release form) when they are switched to the extended…
- Trial name
- NCT00347152
- Testing
- Divalproex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Kansas
Epilepsy, Glioma
Correlation Between SV2A Expression in Tumour Tissue and Efficacy of Levetiracetam in Glioma Patients With Epilepsy
The purpose of this study is to investigate the correlation of SV2A expression in surgically removed tumour and tumour-surrounding tissue of glioma patients suffering from epilepsy with their clinical response to levetiracetam.
- Trial name
- NCT00454935
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Depression, Epilepsy
PEARL Intervention to Reduce Depression Among Adults With Epilepsy
The purpose of this study is to test the effectiveness of a home-based depression treatment intervention called "Program to Encourage Active, Rewarding Lives (PEARL)".
- Trial name
- PEARL (NCT00459329)
- Testing
- Program to Encourage Active, Rewarding Lives (PEARL)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Epilepsy, Mental Retardation
Open Label Study of Zonisamide in the Treatment of Epilepsy in Patients With Mental Retardation
The purpose of this study is to assess the efficacy and tolerability in "real-world" clinical practice, of adjunctive zonisamide treatment in adult patients with developmental disabilities and epilepsy.
- Conditions
- Epilepsy, Mental Retardation, Developmental Disabilities
- Trial name
- NCT00298818
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Epilepsy, Mental Retardation
Use of Sustained Release Antiepileptic Medication (Depakote® ER) for Pediatric Epilepsy in a Mental Retardation/Developmental Disorder Population
This study is being done to see if children with learning problems can learn how to swallow pills without chewing them. The reason this is important is that if a person has seizures, medications must be taken every day.
- Conditions
- Epilepsy, Mental Retardation, Developmental Disabilities
- Trial name
- NCT00207935
- Testing
- Swallow instruction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Epilepsy
Lamotrigine and Oral Contraceptives
The present study evaluates the effect of oral contraceptives on lamotrigine plasma concentrations in a double blind, placebo controlled, cross-over study in patients with epilepsy.
- Trial name
- NCT00266149
- Testing
- Oral contraception, Lamotrigine
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Sleep Deprivation, Epilepsies, Partial
A Study of Lyrica as Treatment for Sleep Problems in Patients With Sleep Problems and Seizures
The purpose of this study is to determine the effects of pregabalin on sleep problems in patients with seizures.
- Trial name
- NCT00643136
- Testing
- Pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 17 people
- Sponsor
- Pfizer
Intractable Epilepsy
The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy
The primary aim of the study is to determine the effect of reducing the number and/or dose of anti epileptic drugs on an individual's quality of life and seizure control in people with difficult to control epilepsy and who are on…
- Trial name
- NCT00647322
- Testing
- Reduction of anti-epileptic medications, No drug change
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- Institute of Child Health
Pediatric Epilepsy
Pediatric Switch Study for Children and Adolescent Patients With Epilepsy
To assess the tolerability of switching from Depakote Sprinkle Capsules or Depakote tablets to Depakote ER tablets in the pediatric population.
- Trial name
- NCT00646711
- Testing
- Depakote Delayed-Release/Depakote Sprinkle, Depakote ER
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Abbott
Epilepsy
An Open-Label Interaction Study to Look at the Effects of Brivaracetam on Phenytoin When Taken Together in 15 Adult Patients With Epilepsy.
The primary objective of this Phase I study in 15 adult subjects suffering from epilepsy and chronically treated with phenytoin monotherapy is to evaluate the effect of steady-state ucb 34714 administration on the steady-state…
- Trial name
- NCT00426673
- Testing
- Brivaracetam (ucb34714)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- UCB Pharma
Epilepsy, Seizures
Monitoring Patients With Uncontrolled Epilepsy
This study is designed to evaluate patients with uncontrolled seizures. Seizures can be associated with and monitored by abnormal electrical activity in the brain.
- Trial name
- NCT00001149
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebrovascular Disorder, Epilepsy
Brain Blood Flow Studies of Language and Memory
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal…
- Trial name
- NCT00001288
- Testing
- 15 O Water, FDG
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)