Clinical trials: Epilepsy
Primary Mitochondrial Disease
OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)
The goal of this clinical trial is to learn about the treatment effects of the investigational new drug OMT-28 in patients with Primary Mitochondrial Disease.
- Trial name
- PMD-OPTION (NCT05972954)
- Testing
- OMT-28
- Where
- 9 sites in Germany, Italy and 1 more
- Volunteers
- 28 people
- Sponsor
- Omeicos Therapeutics GmbH
Epilepsy, Epilepsy, Temporal Lobe
PRX-00023 Therapy in Localization-Related Epilepsy
Background: The brain chemical serotonin helps nerve cells communicate. Previous research suggests that serotonin activity may be lower in brain areas where seizures start, and that increasing activity at the serotonin receptor…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01281956
- Testing
- PRX-00023
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Onchocercal Subcutaneous Nodule, Epilepsy
Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study
This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy.
- Conditions
- Onchocercal Subcutaneous Nodule, Epilepsy, Virus
- Trial name
- NCT05868551
- Testing
- nodulectomy
- Where
- South Sudan
- Volunteers
- 40 people
- Sponsor
- Universiteit Antwerpen
Epilepsy
A Conversion Study of Immediate Release (IR) and Modified Release (MR) Forms of Topiramate (TPM)
This multi-center, two-treatment study compares the pharmacokinetic profiles of Immediate Release (IR) and Modified Release (MR) formulations of Topiramate (TPM) in patients with epilepsy.
- Trial name
- NCT01114854
- Testing
- Topiramate IR, Topiramate ER
- Where
- 9 sites in United States
- Volunteers
- 69 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Epilepsy, Generalized
ONO-2017 Study Japanese Patients With Primary Generalized Tonic Clonic Seizures.
To investigate the efficacy and safety of ONO-2017 in combination with antiepileptics in Japanese epileptic patients with generalized tonic-clonic seizures.
- Trial name
- NCT06579573
- Testing
- Cenobamate
- Where
- 25 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Movement Disorders
Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures
This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder.
- Trial name
- NCT00500994
- Testing
- MRI
- Where
- 2 sites in United States
- Volunteers
- 254 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
HIV/AIDS, Hypertension
Evaluating the Impact of a Community Health Worker Program in Neno, Malawi
This protocol concerns the implementation and evaluation of an intervention designed to realign the existing cadre of Community Health Workers (CHW) in Neno District, Malawi to better support the care needs of the clients they…
- Conditions
- HIV/AIDS, Hypertension, Asthma, Diabetes
- Trial name
- NCT03106727
- Testing
- Household model
- Where
- Malawi
- Volunteers
- 122,395 people, healthy volunteers welcome
- Sponsor
- Partners in Health
Epilepsy, Cognitive Dysfunction
Cognitive Function and Glymphatic System in Children with Epilepsy
Epilepsy, one of the most common neurological disorders in childhood, is a chronic brain disease characterized by neurobiological, psychological and cognitive effects.
- Conditions
- Epilepsy, Cognitive Dysfunction, Seizure, Epileptic
- Trial name
- NCT06143241
- Testing
- Threshold IMT, Antiepileptic medication
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ege University
Epilepsy
Clinic-based and Technology-Supported Sleep Intervention for Pediatric Epilepsy
Sleep problems are more common and more severe in children with epilepsy. The purpose of this study is to develop and evaluate the effect of a clinic-based and technology-supported sleep intervention for improving sleep and…
- Trial name
- NCT06661759
- Testing
- Clinic-based and technology-supported sleep intervention
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Epilepsy, Contraception
Women With Epilepsy: a Pilot Study of PK and PD Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users
The investigators will conduct a prospective, seven-month pilot study to explore pharmacokinetic (PK) and pharmacodynamic (PD) effects among women with epilepsy using the levonorgestrel intrauterine system (LNG IUS) for…
- Trial name
- WESAIL (NCT02362373)
- Testing
- levonorgestrel IUS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
BECTS, Epilepsy, Rolandic
Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS)
The social processes depend on complex cognitive mechanisms, which involve mainly the frontal and temporal lobe regions. Patients with early onset frontal and temporal lobe lesions might later develop important deficits in social…
- Trial name
- BECTS (NCT03465566)
- Testing
- IDS;MMSPE;CDI 2;CBCL;tests of facial expression evaluation
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Migraine With Aura, Patent Foramen Ovale
Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP)
The purpose of the study is to compare the rate of comorbidities associated with migraine aura (MA) between persons who have a large circulatory right-to-left shunt (RLS) and those who do not have RLS.
- Trial name
- CAMP (NCT01257880)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Swedish Medical Center
Epilepsy
Double-blind Study in Paediatric Epileptic to Compare the Subject Preference for ESL Suspension Formulation With Alternative Flavours
The purpose of this study is to investigate the taste preference in children of 3 different flavours of the ESL oral suspension.
- Trial name
- NCT02021461
- Testing
- ESL Banana taste, ESL Grape taste, ESL Tutti-Frutti taste
- Where
- 3 sites in Romania, Slovakia
- Volunteers
- 38 people
- Sponsor
- Bial - Portela C S.A.
Epilepsy
Catamenial Epilepsy Treatment
Epilepsy is a disorder in the brain. The brain is full of "nerve" cells. Nerve cells have normal electrical activity to control the many functions of the body.
- Trial name
- NCT01299870
- Testing
- Keishibukuryogan
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Timothy Welty, PharmD
Epilepsy
Fecal Microbiota Transplantation for Epilepsy
Increasing evidences showed the microbiota effects on neuropsychiatric disorders. This clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation for epilepsy.
- Trial name
- NCT02889627
- Testing
- Fecal microbiota suspension
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Epileptic Spasms
Evaluation of the Modified Atkins Diet in Children With Epileptic Spasms
Epileptic spasms are a difficult to treat epileptic condition in young children. The first line treatment is hormonal treatment, in the form of ACTH or oral steroids, which are effective in 60-70% of children.
- Trial name
- NCT03807141
- Testing
- Modified Atkins diet
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Lady Hardinge Medical College
Glioma, Glioma of Brain
Seizure Prophylaxis in Patients With Glioma or Brain Metastasis
This protocol is designed to assess the need for seizure prophylaxis in the perioperative period for patients undergoing neurosurgical procedure (gross-total resection, sub-total resection or biopsy) for suspected diagnosis of…
- Conditions
- Glioma, Glioma of Brain, Brain Tumor
- Trial name
- NCT03436433
- Testing
- Lacosamide, Levetiracetam
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Epilepsy
A Multi-center RWS of Perampanel as an add-on Treatment for Epileptic Seizures in Chinese Children
This study is a multi-center, real-word clinical trial. The purpose of this study is to evaluate the safety and effectiveness of perampanel as an add-on treatment for epileptic seizure, and to find the effective maintenance and…
- Trial name
- NCT05274035
- Testing
- Perampanel
- Where
- 5 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Children's Hospital
Seizures, Epilepsy
Thalamic Stimulation for Epilepsy Study
In this study, the investigator aims to perform cortical stereo electroencephalogram (sEEG) recordings during simultaneous anterior nucleus of the thalamus (ANT) recording and stimulation to better understand the following: 1)…
- Conditions
- Seizures, Epilepsy, Seizure Disorder
- Trial name
- NCT04102254
- Testing
- ANT recording and stimulation
- Where
- United States
- Sponsor
- Duke University
Epilepsy
Safety, Tolerability, and Exploratory Efficacy of Adjunctive EQU-001 for Seizures in Adults With Epilepsy
This is a double-blind, placebo controlled, randomized study of dose-ranging safety, tolerability, exploratory efficacy of adjunctive EQU-001 for seizures using the continuous reassessment method in patients diagnosed with…
- Trial name
- NCT05063877
- Testing
- EQU-001
- Where
- 10 sites in United States, Israel
- Volunteers
- 43 people
- Sponsor
- Equilibre Biopharmaceuticals B.V.