Clinical trials: Epilepsy
Epilepsy, Sleep
Prospective Longitudinal Study of Sleep, Brain Activity, and Plasma Analyses in Patients Undergoing Epilepsy Surgery
The goal of this observational study is to understand how sleep and brain activity change after epilepsy surgery in adults with drug-resistant epilepsy.
- Conditions
- Epilepsy, Sleep, Drug Resistant Epilepsy, Epilepsy Sleep
- Trial name
- NCT07885826
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epilepsy
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients…
- Trial name
- NCT02107989
- Testing
- MRI, MEG
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
A Device to Prevent Unexpected Death in Epilepsy
The study has the objective to demonstrate safety and effectiveness of the Korus device in identifying body positioning. Primary Objective Validate the sensor system in Korus for body position detection using a pressure-based…
- Trial name
- NCT07877896
- Testing
- Study Subjects
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Seizures, Epilepsy
Ear-Seizure Detection (EarSD) Study
The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional…
- Trial name
- EarSD001 (NCT06598189)
- Testing
- Ear-SD, Electroencephalogram
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Felicia Chu
Neurological Disorders, Neuroscience
Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI
In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques.
- Conditions
- Neurological Disorders, Neuroscience, Epilepsy, Brain Injuries, Focal
- Trial name
- AURORA (NCT07865546)
- Testing
- Functional neuroimaging
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imago 7 Fondazione di Ricerca onlus
Epilepsy Lobe Temporal, Healthy
Spatial Memory and Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) can cause memory disorders, including long-term forgetfulness due to a failure to consolidate verbal but also spatial information.
- Conditions
- Epilepsy Lobe Temporal, Healthy, Epilepsy
- Trial name
- EPINAVIG (NCT06847152)
- Testing
- spatial memory test
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Epilepsy, Drug-resistant Focal Epilepsy
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive…
- Conditions
- Epilepsy, Drug-resistant Focal Epilepsy, Healthy Controls
- Trial name
- BRAVE (NCT07249034)
- Testing
- 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy
Epilepsy and Driving
Epilepsy can lead to cognitive impairments, particularly in attention, which may affect daily activities such as driving. Driving plays a key role in maintaining autonomy and is essential for the social and professional…
- Trial name
- EPICO (NCT07026591)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy, Seizures
Pharmacological Modulation of Brain Oscillations in Memory Processing
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity.
- Conditions
- Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders
- Trial name
- NCT05594017
- Testing
- Scopolamine (0.4mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Seizures, Seizure Disorder
Modulating Movement Intention Via Cortical Stimulation
The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies.
- Conditions
- Seizures, Seizure Disorder, Psychogenic Movement Disorder
- Trial name
- NCT03233399
- Testing
- rTMS of left or right angular gyrus (AG) or frontal cortex (FC), Anodal tDCS of left or right AG or FC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Epilepsy, Unspecified, Pharmacologically Resistant, Memory Impairment
Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the…
- Trial name
- MemO-Epi (NCT01919957)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Epilepsy, Temporal Lobe, Drug Resistant Epilepsy
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy
The goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures.
- Trial name
- EpHR-DP (NCT07835594)
- Testing
- Textile-based wearable electrocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Other Forms of Epilepsy, Treatment Resistant
TDCs to Treat Drug-resistant Epilepsy
Epilepsy is the fourth overall neurologic disorder, regardless of age and gender, affecting more than 50 million people worldwide.
- Trial name
- NCT05825274
- Testing
- Active Cathodal tDCS
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Spanish Foundation for Neurometrics Development
Acquired Brain Injury Including Stroke, Epilepsy
Cognitive Rehabilitation Using Neurofeedback With Brain-computer Interface
The goal of this clinical trial is to determine whether a Brain-Computer Interface Neurofeedback Training (BCI-NFT) programme can improve cognitive outcomes, and whether electroencephalography (EEG)-based measures can serve as…
- Trial name
- NCT07828496
- Testing
- Brain-computer interface with neurofeedback with 3D game sessions
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents
A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935
The purpose of this study is to determine the brain cholesterol 24S-hydroxylase (CH24H) enzyme occupancy of TAK-935 after single oral dose in healthy participants using the positron emission tomography (PET) ligand [18F]MNI-792…
- Trial name
- NCT02497235
- Testing
- TAK-935, [18F]MNI-792 (tracer)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Takeda
Epilepsy
TAK-935 Multiple Rising Dose Study in Healthy Participants
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of multiple rising doses of TAK-935 in healthy participants.
- Trial name
- NCT02539134
- Testing
- TAK-935
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Takeda
Epilepsy
SeizEAR Safety Study
Determine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG).
- Trial name
- NCT07088835
- Testing
- SeizEAR
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypercholesterolemia, Carotid Intimal Medial Thickness 1
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
This research is being done to evaluate the short term and long term effects of ketogenic diets on measures of cardiovascular health.
- Conditions
- Hypercholesterolemia, Carotid Intimal Medial Thickness 1, Seizure, Epilepsy
- Trial name
- NCT02694094
- Testing
- Modified Atkins or Ketogenic Diet
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dravet Syndrome (DS)
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, usually caused by de novo pathogenic SCN1A variants, characterized by early-onset prolonged febrile seizures, subsequent drug-resistant polymorphic epilepsy…
- Trial name
- TEMBO-DS (NCT07801404)
- Where
- 9 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS