Clinical trials: Environmental Factors
Attention-Deficit Hyperactivity Disorder
Johnston County ADHD Study: Environmental, Reporductive, and Familial Risk Factors for Attention-Deficit Hyperactivity Disorder (ADHD)
We propose a population-based case-control study among 7000 elementary school children in semi-rural Johnston County, NC. Teachers will complete a screening form on each child. Controls will be randomly selected.
- Trial name
- NCT00339729
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Male Infertility
Personalized Signature of Chronic Inflammation and Early Aging Predictive of the Comorbidities in Infertile Men
The aim of the project is identify new biomarkers and/or prognostic factors in order to develop personalized strategies to prevent the onset of tumor and/or non tumor comorbidity in infertile men.
- Trial name
- NCT06082362
- Testing
- Collection of clinical and biological material
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Spondylarthritis, Primary Systemic Vasculitis
Impact of Environmental Factors on Disease Activity in Spondyloarthritis (SPA): Results of the Prospective Co-Env Cohort
Susceptibility to SPA has been shown to be largely genetically determined. The objective of this study was to prospectively investigate the impact of several environmental factors on disease activity.
- Trial name
- CoEnv (NCT01314547)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Socio-economic, Meteorological and Environmental Factors Associated With the Incidence of COVID-19
Socio-demographic factors in relation to the diagnosis of COVID cases are increasingly mentioned in the role of transmission, but unfortunately with a small number of conclusive publications on French data.
- Trial name
- NCT05379621
- Testing
- COVID-19 infection
- Where
- France
- Volunteers
- 28,377 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease…
- Trial name
- DMR100-IRB-010 (NCT01311921)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Asthma, Allergy
Urban Environmental Factors and Childhood Asthma
Minority children who grow up in poor urban neighborhoods have the highest rates of asthma, and also experience greater morbidity from acute exacerbations of this disease.
- Trial name
- URECA (NCT00114881)
- Where
- 4 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1, Ulcerative Colitis
Machine Learning Approach to Study the Interactions Between Environment and Intestinal Tissue Homeostasis in IBD
The intestinal epithelial barrier is one of the most important security checkpoints of our body that constrains harmful factors from invading mucosal surfaces and facilitates the absorption of nutrients and water.
- Trial name
- NCT06120322
- Testing
- Environmental factor monitoring; collection of blood, feces and urine. For UC: collection of 8 additional biopsies
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Precocious Puberty, Overweight and Obesity
Overweight and Obesity and Puberty Development Cohort Study
Precocious puberty and childhood overweight and obesity are important public health problems that both had adverse effects, which including psychological symptom in childhood, short final height or reproductive dysfunction in…
- Trial name
- NCT04113070
- Testing
- Anthropometric measuring, Growth environment evaluation
- Where
- China
- Volunteers
- 14,100 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Unrecognized Condition
Interaction of Genetic and Environmental Factors for Body Fat Mass Control
Although the effect of interaction between genetic and environmental factors on body fat mass (BFM) has been proposed, how lifestyle changes affect body weight with regard to the genetic composition needs to be verified.
- Trial name
- NCT04299698
- Testing
- lifestyle
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Sickle Cell Disease
Biological, Genetic and Environmental Involved in the Complications of Sickle Cell Disease
The objective of the study is to refine our knowledge on the physiopathology of the symptoms and the complications for the patients affected by a drepanocytic syndrome.
- Trial name
- NCT04205123
- Testing
- sickle cell syndrome
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Erasme University Hospital
Breast Cancer
The Sister Study: Genetic and Environmental Risk Factors for Breast Cancer
The Sister Study is prospectively examining environmental and familial risk factors for breast cancer and other diseases in a cohort of 50,884 sisters of women who have had breast cancer.
- Trial name
- NCT00047970
- Where
- United States
- Volunteers
- 50,884 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Hypertension
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)
Our objective is to develop a community-based cohort and novel genomic science resource for defining the biological significance of ancestry-related genomic variation in African-Americans within the GENE-FORECAST :GENomics…
- Trial name
- NCT02055209
- Where
- 2 sites in United States
- Volunteers
- 670 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease (CKD)
Trace Element Imbalances in Dialysis Patients With CKD: the Role of Hemodialysis
Chronic kidney disease (CKD) is associated with alterations in the balance of trace elements and metals, which may result from reduced dietary intake, impaired renal function, dialysis-related removal, or environmental exposure.
- Trial name
- SQUIL-CKD (NCT07808944)
- Testing
- Compare blood concentrations of selected trace elements and metals before and after hemodialysis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Environmental and Genetic Factors on Lung Function
ONES Grant: CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability
The purpose of this research study to understand how environmental and genetic factors may be involved in lung function. Study participants will undergo a 1-day screening that includes a blood draw and breathing testing, return…
- Trial name
- NCT03599206
- Testing
- Ozone, Filtered Air
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Robert Tighe, MD
Environmental Exposure, Individual Difference
Individual and Environmental Risk Factors for Unscheduled Hospitalizations of Elderly People
The elderly are weakened by the accumulation of chronic diseases. Their acute decompensation often leads to unscheduled hospitalization, which constitutes a breach of care with often serious consequences in terms of morbidity and…
- Trial name
- RIEHO-C (NCT04326556)
- Testing
- Prospective cohort for etiological and prognostic purposes
- Volunteers
- 70 people
- Sponsor
- Virginia BRANCO
Alzheimer Disease, Schizophrenia
Multi-center Imaging Genetics Studies in China
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
- Conditions
- Alzheimer Disease, Schizophrenia, Major Depressive Disorders
- Trial name
- CHIMGEN (NCT02681822)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Type 1 Diabetes Mellitus (T1DM), Healthy Control
Environmental Determinants of Type 1 Diabetes Risk
To analyze the environmental risk factors for type 1 diabetes in China.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Healthy Control, Relatives to/Carers of Patients
- Trial name
- NCT07835724
- Where
- China
- Volunteers
- 11,240 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Autism, Developmental Disabilities
Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.
- Trial name
- NCT00106652
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Nature, Human, Mental Health Wellness 1
Effects of Forest Bathing in Vancouver, B.C. Parks
This study aims to investigate environmental factors that influence people's responses to the Japanese practice of forest bathing in Vancouver, B.C. parks.
- Conditions
- Nature, Human, Mental Health Wellness 1, Stress, Psychological, Blood Pressure
- Trial name
- NCT05502588
- Testing
- Self-Guided Forest Bathing, Guided Forest Bathing
- Where
- 4 sites in Canada
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of British Columbia