Clinical trials: Engorgement
Glaucoma
Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma
To evaluate the effect of brimonidine tartrate 0.025% on conjunctival hyperemia in patients treated with netarsudil 0.02%/latanoprost 0.005% mono-therapy for intraocular pressure lowering.
- Trial name
- NCT07209410
- Testing
- Brimonidine Tartrate Ophthalmic 0.025%
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
Open Angle Glaucoma, Ocular Hypertension
Evaluation of Hyperemia With the Use of Ocular Prostaglandin Analogues
This study will evaluate hyperemia and ocular surface tolerability in patients on prostaglandin analogues
- Trial name
- NCT00539526
- Testing
- Bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005% eye drops
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Allergan
Breastfeeding, Engorgement of Breast Associated With Childbirth, Postpartum
The Effect of Oketani Massage on Breastfeeding Success and Breast Engorgement in Mothers Delivering by Cesarean Section
The aim of this study was to examine the effect of octani massage on breastfeeding success and breast engorgement in mothers who gave birth by cesarean section.
- Trial name
- NCT05903846
- Testing
- Oketani massage
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University
Intraoperative, Venous Congestion
Venous Congestion And Delirium After Cardiac Surgery
Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery.
- Conditions
- Intraoperative, Venous Congestion, Postoperative Delirium (POD), Cardiac Surgery
- Trial name
- NCT07285187
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POD assessments
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhuan Zhang
Intraoperative, Venous Congestion
Venous Congestion and Cardiac Surgery-Associated Acute Kidney Injury
Venous pressure is often overlooked as an important hemodynamic parameter. Elevated venous pressure and blood stasis in organ tissues can lead to interstitial edema.
- Conditions
- Intraoperative, Venous Congestion, Cardiac Surgery-associated Acute Kidney Injury
- Trial name
- NCT07232277
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters and kidney function assessments, collection of biological (laboratory) parameters
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Zhuan Zhang
Breast Engorgement
Acupuncture for Breast Engorgement During Lactation
Breast engorgement which may manifest swell, throb, and cause mild to extreme pain is the common difficulty for breast feeding woman.
- Trial name
- NCT03230760
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
POAG, Primary Open Angle Glaucoma
A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma
The purpose of the study is to provide evidence that the efficacy of Xalatan will be superior to Apo-latanoprost and Co-latanoprost in the reduction of intraocular pressure in patients with primary open angle glaucoma.
- Conditions
- POAG, Primary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT02792803
- Testing
- Xalatan, Apo-Latanoprost, Co-Latanoprost
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. David Yan
Cardiac and Aortic Surgery, Cardiac Anaesthesia
Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients
The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients.
- Conditions
- Cardiac and Aortic Surgery, Cardiac Anaesthesia, Venous Congestion, Fluid Resuscitation
- Trial name
- VExUS-CS (NCT07183397)
- Testing
- VExUS & Cardiac Ultrasound
- Volunteers
- 250 people
- Sponsor
- Medical University of Vienna
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function
- Trial name
- NCT06867198
- Testing
- Peanuts
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Georgia State University
Coronary Artery Disease
Regadenoson and Adenosine
The aim of the study is to test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve.
- Trial name
- NCT01809743
- Testing
- Regadenoson central -central, Regadenoson peripheral - peripheral, Regadenoson central - peripheral
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Lokien van Nunen
Cardiovascular Risk Factor, Endothelial Dysfunction
Interrupting Sitting With High Intensity Exercise on Vascular Function in Adolescents Before and After a Mixed Meal
This study aims to investigate the effect of interrupting a three hour bout of prolonged sitting with high intensity interval exercise on lower limb blood vessel function in adolescents before and after a mixed meal challenge.
- Trial name
- NCT04337385
- Testing
- Interrupting 3 hours of prolonged sitting with high intensity interval exercise, 3 hours of prolonged sitting
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Coronary Artery Disease
Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia
The purpose of this study is to determine if regadenoson is as safe and effective as adenosine when used in the cardiac catheterization lab during measurement of coronary flow reserve and fractional flow reserve.
- Trial name
- NCT01161121
- Testing
- adenosine, regadenoson
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- St. Louis University
Cardiogenic Pulmonary Edema
Helmet CPAP Versus HFNC in Acute Cardiogenic Pulmonary Edema
This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Oedema (ACPE) patients in the Emergency Department (ED) delivered by Helmet CPAP (hCPAP) and…
- Trial name
- HCPAPvsHFNC (NCT04005092)
- Testing
- hCPAP versus HFNC
- Where
- Malaysia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Hospital Raja Permaisuri Bainun
Chronic Kidney Diseases, Blood Pressure
Curcumin and Exercise in Chronic Kidney Disease
Chronic kidney disease (CKD) is associated with a pro-oxidative and pro-inflammatory state, and this is thought to contribute to a decrease in vascular function leading to greater cardiovascular disease (CVD) risk.
- Conditions
- Chronic Kidney Diseases, Blood Pressure, Hyperemia, Vasoconstriction
- Trial name
- NCT04132648
- Testing
- Curcumin
- Sponsor
- University of Iowa
Raynaud Disease, Hyperemia
PORH and Response to Cold in Raynaud's Phenomenon.
The main objective of the study is to determine if implication of epoxy-eicosatriénoïc acids (EETs) and NO during cutaneous post-occlusive hyperemia differs between patients with Raynaud phenomena and healthy volunteers, by…
- Conditions
- Raynaud Disease, Hyperemia, Cold
- Trial name
- REFRAIN (NCT02183779)
- Testing
- post-occlusive hyperemia, cooling box, L-NMMA and Fluconazole dermic injection
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Coronary Artery Stenosis of Unclear Hemodynamic Relevance
Determination of Coronarphysiological Parameters With the Method of Thermodillution
The gold standard to induce coronary hyperemia for measurement of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) is adenosine, but it exerts several side effects due to…
- Trial name
- NCT03101696
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cardiac Surgical Procedures, Hemodynamics
Structured Hemodynamic Assessment to Guide Care After Cardiac Surgery
This multicenter pilot randomized controlled trial will evaluate whether providing treating physicians with a structured hemodynamic assessment influences care after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures, Hemodynamics, Fluid Therapy, Acute Kidney Injury
- Trial name
- UTF-in-CVICU (NCT07792707)
- Testing
- Expert Report of a Structured Hemodynamic Assessment, Standard Care (in control arm)
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Venous Congestion, Heart Failure Acute
Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart Failure
This study evaluates whether natriuresis-guided diuretic therapy improves outcomes in patients with acute heart failure (AHF) and severe congestion.
- Conditions
- Venous Congestion, Heart Failure Acute, VExUS, Diuretics
- Trial name
- VANTAGE-HF (NCT07558798)
- Testing
- Natriuresis-guided escalation of loop diuretics
- Where
- 2 sites in Norway
- Volunteers
- 270 people
- Sponsor
- University Hospital, Akershus
Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Incorporating the Venous Excess Ultrasound Score (VExUS Score) Into Contemporary Haemodynamic Risk Assessment in Pulmonary Arterial Hypertension: The INVEXUS-PAH Study
This prospective observational study aims to evaluate the relationship between the Venous Excess Ultrasound Score (VEXUS) and the ESC/ERS 2022 simplified four-strata risk assessment model in adult patients with World Health…
- Trial name
- INVEXUS-PAH (NCT07266012)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Istanbul University - Cerrahpasa
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern