Clinical trials: Energy Expenditure
Cerebral Palsy
Effect of Dysport Injections on Energy Expenditure and Walking Efficiency in Children With Cerebral Palsy
This study aims to evaluate the efficacy of single event multi level chemoneurolysis with the abobotulinumtoxin A drug, Dysport®, on walking energy expenditure and gait in children with spastic diplegia cerebral palsy.
- Trial name
- NCT03469999
- Testing
- Dysport Injectable Product
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Alzheimer's Disease (AD)
Trial of Oxaloacetate in Alzheimer's Disease (TOAD)
The purpose of this study is to determine if oxaloacetate (OAA) is safe and tolerable at doses of up to 2 grams per day in people with Alzheimer's disease (AD).
- Trial name
- TOAD (NCT02593318)
- Testing
- Oxaloacetate (OAA) 1g, Oxaloacetate (OAA) 2g
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Russell Swerdlow
Bipolar Depression
Lamotrigine Therapy in Geriatric Bipolar Depression
We propose to study the efficacy and tolerability of lamotrigine in the treatment of older adults with bipolar depression and to compare measures of brain energy metabolism between older subjects with bipolar depression and…
- Trial name
- NCT00720473
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Obesity, Diabetes
Framingham State Food Study
This study will evaluate the effects of dietary composition on energy expenditure and chronic disease risk factors, while also exploring physiological mechanisms underlying these effects.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- (FS)2 (NCT02068885)
- Testing
- Feeding study
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Child, Critical Illness
Measuring the Metabolic Cost of Fever
Fever is part of the body's immune response, often triggered by infection. Fever is commonly treated with medicines such as paracetamol, mainly because people feel unwell with fever.
- Conditions
- Child, Critical Illness, Fever
- Trial name
- IGUANA (NCT02939781)
- Testing
- Indirect calorimetry
- Volunteers
- 12 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Obesity
A Study to Measure Energy Expenditure and Food Intake in Participants With Obesity Using Tirzepatide
This is a study of tirzepatide in participants with obesity. The main purpose is to learn more about how tirzepatide affects the number of calories participants burn and the amount of food they eat.
- Trial name
- NCT04081337
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Eli Lilly and Company
Transtibial Amputation
Evaluation of a Modified Running-specific Prosthetic Foot
The goal of this study is to evaluate endurance, walking performance, mobility, and perceived exertion of transtibial prosthesis users (i.e., study participants) walking with a conventional energy storing prosthetic foot (ESF)…
- Trial name
- NCT02440711
- Testing
- Energy storing foot (ESF), Modified running specific foot (mRSF)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Resting Energy Expenditure, Thermogenesis
MIrabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT05990387
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Heart Failure, Diabetes
Thiamine and Acute Decompensated Heart Failure: Pilot Study
Heart failure remains an increasing cause of morbidity and mortality in the United States even in the face of recent advances in the treatment of cardiovascular disease.
- Trial name
- NCT00680706
- Testing
- Thiamine
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Baystate Medical Center
Abdominal Obesity
Multi-component Workplace Energy Balance Intervention
The purpose of the WorkACTIVE-P study is to assess the outcome of an innovative multi-component intervention focused on increasing energy expenditure and re-balancing the disrupted energy balance equation of sedentary workplaces…
- Trial name
- WorkACTIVE-P (NCT02561611)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pennington Biomedical Research Center
Obesity, Healthy Volunteers
Brain Dopamine Function in Human Obesity
Background: Dopamine is a natural chemical in the brain that may influence eating behavior and physical activity. Researchers want to measure the brain s dopamine activity and understand how it differs in people with obesity.
- Conditions
- Obesity, Healthy Volunteers, Overweight
- Trial name
- NCT03648892
- Testing
- [c11] raclopride, [18F]fallypride
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Caloric Intake and Energy Metabolism
Assessment of Energy Balance
The primary purpose of this study is to test different methods of measuring energy balance, including food intake and energy expenditure.
- Trial name
- EnergyBalanc (NCT01678885)
- Testing
- Digital Photography of Foods, doubly labeled water, IDEEA
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Pennington Biomedical Research Center
Obesity, Impaired Glucose Tolerance
The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women
This study will look at the effect of exenatide, a drug which has been approved for the treatment of type 2 diabetes, on body weight, appetite and energy expenditure among moderately obese women without diabetes.
- Trial name
- NCT00456885
- Testing
- exenatide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Metabolic Syndrome
Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
There is an ongoing and worsening problem with obesity in the developed, and much of the developing world. Although it has long been realized that Western diets that are rich in sugar and fat play an important role in this, it…
- Trial name
- NCT03138382
- Testing
- Vestibular Nerve Stimulator
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Lipodystrophy
Short-term Effects of Leptin in People With Lipodystrophy
Background: Lipodystrophy is a condition where people do not have enough fat in the body. People with lipodystrophy can have problems such as diabetes or an enlarged liver.
- Trial name
- NCT01778556
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypothalamic Obesity
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
The proposed multicenter study will test the effect of glucagon-like peptide (GLP)-1 agonist exenatide once weekly extended-release (ExQW, Bydureon®) on clinical outcomes and metabolic parameters in a double-blind…
- Trial name
- ECHO (NCT02664441)
- Testing
- Exenatide
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Seattle Children's Hospital
Healthy Young Adults
An Evaluation of the Energy Expenditure From Wii Fit Games
The purpose of this study is to provide energy expenditure data on Wii Fit / Wii Fit Plus games as compared with resting and treadmill walking/running.
- Trial name
- NCT01561716
- Testing
- Wii Fit
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Obesity, Diabetes
Modeling the Epidemiologic Transition Study
This project examines whether individuals' amount of activity energy expenditure (AEE) is related to adiposity and adiposity/diabetes-related hormones in a diverse sample of 2500, and to test the ecological hypothesis that a…
- Trial name
- METS (NCT02925156)
- Where
- United States
- Volunteers
- 2,506 people, healthy volunteers welcome
- Sponsor
- Loyola University
Whole Body Energy Metabolism
Effects of 12 Weeks of Omega 3 Supplementation on Resting Metabolic Rate
Fatty acids are the main components of the cell membranes. It has been demonstrated that diet can alter the characteristics and function of many membranes in the body, which has an effect on cardiovascular and metabolic health.
- Trial name
- NCT02092649
- Testing
- Omega-3 Complete
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Guelph