Clinical trials: Endovascular Thrombectomy, open to volunteers
Acute Ischemic Stroke (AIS)
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide.
- Trial name
- TOPAZ (NCT07734792)
- Testing
- Tirzepatide, Standard Medical Care (SMC)
- Where
- China
- Volunteers
- 726 people
- Sponsor
- yifang zhu
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Stroke, Acute Ischemic, Endovascular Thrombectomy
ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
Study Design and Duration: This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of REACT.
- Conditions
- Stroke, Acute Ischemic, Endovascular Thrombectomy, Acute Ischemic Stroke AIS
- Trial name
- ACT-REACT (NCT07687056)
- Testing
- Tenecteplase or Alteplase- depending upon availability at each treating centre, Control
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke AIS, Stroke Acute
ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain has a prospective, randomized, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design.
- Conditions
- Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
- Trial name
- ACT-WHEN (NCT06320431)
- Testing
- Tenecteplase
- Where
- 24 sites in Australia, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy
Acute ischemic stroke caused by blockage of a large brain artery can lead to severe disability. Endovascular thrombectomy is a catheter-based procedure used to remove the blood clot and restore blood flow.
- Trial name
- CARE-EVT (NCT06339411)
- Testing
- Cerebrolysin
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Periprocedural Vessel Perforation, Acute Ischemic Stroke
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke
A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1.
- Trial name
- PREVENT (NCT06394180)
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Lower Limb Arterial Occlusion
The ArtixASCEND Study
This study is a post-market, prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the Artix Thrombectomy System in patients with acute lower extremity arterial occlusions.
- Trial name
- NCT07135895
- Testing
- Artix Thrombectomy System
- Where
- 23 sites in United States
- Volunteers
- 250 people
- Sponsor
- Inari Medical
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Ischemic Stroke
Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy
Endovascular thrombectomy (EVT) is a procedure that improves recovery for people who suffer from a stroke by removing blood clots from large blood vessels in the brain.
- Trial name
- LEAST (NCT07511543)
- Testing
- Semaglutide
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease
This study will explore the safety and efficacy of BASIS technology in ICAS-LVO lesions through a multicenter, prospective, registry, observational single-arm study.By registering intraoperative recanalization using this…
- Trial name
- NCT06881420
- Testing
- BASIS technique
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Medical University Union Hospital
Acute Ischemic Stroke
Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial
The trial will be a randomized, double-blind, controlled, single-center trial. The purpose of this trial is to determine the efficacy and safety of semaglutide in improving neurological outcomes after endovascular thrombectomy…
- Trial name
- STARS (NCT07030621)
- Testing
- Semaglutide 0.5 mg, Normal Saline
- Where
- China
- Volunteers
- 436 people
- Sponsor
- RenJi Hospital
Acute Ischemic Stroke
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel…
- Trial name
- SUPERSTAR (NCT07555977)
- Testing
- Super Large Bore Catheter, Stent Retriever Thrombectomy
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke
Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke
It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core.
- Trial name
- MATCH (NCT06870448)
- Testing
- Methyprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ichemic Stroke
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
The ELATE study is a prospective, observational study designed to evaluate the clinical outcomes and safety profile of endovascular thrombectomy compared with best medical treatment alone in patients presenting with acute…
- Trial name
- ELATE (NCT07922317)
- Testing
- Endovascular treatment
- Where
- Vietnam
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Endovascular Thrombectomy, Large Vessel Occlusion
Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)
The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each…
- Conditions
- Endovascular Thrombectomy, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- TRACK-LVO Late (NCT06200753)
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital
Stroke, Ischemic, Stroke, Acute
Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke
A phase III randomized, multi-center, double-blinded, placebo-controlled clinical trial that will examine two strategies for the treatment of acute ischemic stroke associated with a large vessel anterior occlusion within 4.5…
- Trial name
- DIRECT-TNK (NCT05199194)
- Testing
- Tenecteplase
- Where
- 13 sites in Brazil
- Volunteers
- 398 people
- Sponsor
- Hospital Moinhos de Vento
Acute Ischemic Stroke
Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke
The purpose of this study is to determine the safety and feasibility of using intra-arterial Tenecteplase in patients undergoing blood clot extraction for treatment of acute ischemic (non-bleeding) stroke.
- Trial name
- TNK-FLOW (NCT06781385)
- Testing
- Intra-arterial Tenecteplase, Intra-arterial Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Stroke, Acute Ischemic
Role of Hypothermia in Endovascular Stroke Thrombectomy
Reducing or suspending the increase of the infarcted core, i.e., "freezing" the ischemic penumbra, may help improve the efficacy of mechanical thrombectomy.
- Trial name
- COOLING (NCT06109376)
- Testing
- hypothermia, thrombectomy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Xinqiao Hospital of Chongqing
Stroke, Acute Ischemic
Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke
Stroke is a leading cause of disability and mortality worldwide. Despite the clinical benefit of mechanical thrombectomy, 1 out of 2 patients treated are functionally independent at 90 days.
- Trial name
- IA-SUCCESS (NCT06768138)
- Testing
- Intra-arterial infusion of Alteplase
- Where
- France
- Volunteers
- 626 people
- Sponsor
- Central Hospital, Nancy, France
Acute Ischemic Stroke
Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well
SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterior circulation between 24 and…
- Trial name
- SELECT LATE (NCT07115940)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 6 sites in United States
- Volunteers
- 408 people
- Sponsor
- Amrou Sarraj