Clinical trials: Endovascular Thrombectomy
Acute Ischemic Stroke
Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)
Stroke is a common cause of disability. The most common type of stroke, an ischemic stroke, is caused by a blood vessel in the brain getting blocked by a clot.
- Trial name
- CoPrime (NCT06638151)
- Testing
- aspirin + clopidogrel, Aspirin
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Ischemic Stroke, Acute, Endovascular Thrombectomy
Effects of Transcranial Magnetic Stimulation After Endovascular Treatment for Acute Ischemic Stroke
This is a multicenter, randomized, double-blind, sham-controlled trial, to determine the efficacy and safety of cTBS in treating patients with acute ischemic stroke after endovascular treatment.
- Trial name
- NCT06639360
- Testing
- Transcranial Magnetic Stimulation Active
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
Kanagawa Intravenous and Endvascular Treatment Registry
The K-NET registry is a prospective, multicenter, observational registry study for all consecutive patients who received intravenous tPA therapy and/or endovascular treatment for acute ischemic stroke.
- Trial name
- K-NET (NCT05213533)
- Where
- Japan
- Volunteers
- 4,000 people
- Sponsor
- St. Marianna University Toyoko Hospital
Mechanical Thrombectomy, Large Ischemic Core
Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core
RESCUE-Japan LIMIT(Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Large IscheMIc core Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market…
- Trial name
- NCT03702413
- Testing
- Endovascular treatment
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Hyogo Medical University
Ischemic Stroke, Anterior Cerebral Circulation
Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
- Conditions
- Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation
- Trial name
- AMETIS 2 (NCT07235514)
- Testing
- General Anesthesia, Procedural sedation
- Where
- 16 sites in France
- Volunteers
- 958 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ischemic Stroke
Reperfusion Injury After Endovascular Stroke Treatment
Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO).
- Trial name
- DYNASTROKE (NCT05273216)
- Testing
- Transcranial Duplex Sonography, Brain MRI, Blood biomarkers
- Where
- 3 sites in Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Ischemic Stroke, Stroke
Australasian Nanoparticle-mediated Magnetically Enhanced Diffusion for Ischemic Stroke
Rapidly restoring blood flow to the brain in patients with stroke caused by a blocked blood vessel in the brain is the key to reducing disability.
- Trial name
- AusNanoMED (NCT06495671)
- Testing
- Magnetically enhanced diffusion
- Where
- 7 sites in Australia
- Volunteers
- 30 people
- Sponsor
- University of Melbourne
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Stroke, Ischemic
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke is a multi-centers registration. It starts in Jan 2019. The key items in the registration form include basic demographic profiles, past medical history, time…
- Trial name
- TREAT-AIS (NCT05281055)
- Testing
- Endovascular thrombectomy
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- National Taiwan University Hospital
Acute Stroke
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel…
- Trial name
- SEACOAST (NCT03737786)
- Testing
- Tight control of end-tidal CO2 levels
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Stroke, Vascular Occlusion
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from…
- Conditions
- Stroke, Vascular Occlusion, Endovascular Treatment, Mechanical Thrombectomy
- Trial name
- RESTORE (NCT05311605)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke
Stroke Research Consortium in Northern Bavaria (STAMINA)
Each year, approximately 15 million people suffer a stroke worldwide of which 80% are due to ischemic cerebral infarction. Based on the results of randomized controlled trials, treatment options and patient outcomes in acute…
- Trial name
- STAMINA (NCT04357899)
- Testing
- thrombolysis therapy, endovascular therapy, decompressive surgery
- Where
- 2 sites in Germany
- Volunteers
- 3,769 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Ischemic Stroke, Artificial Intelligence (AI)
AI-Driven CTA Reconstruction for Intracranial LVO
Acute ischemic stroke (AIS) caused by intracranial large vessel occlusion (LVO) in the anterior circulation significantly contributes to stroke-related disability and mortality.
- Conditions
- Acute Ischemic Stroke, Artificial Intelligence (AI), Endovascular Thrombectomy, CT Angiography
- Trial name
- SMART-AI (NCT06645405)
- Testing
- AI algorithm
- Where
- 2 sites in China
- Volunteers
- 174 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke
A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
A phase IIb clinical study to evaluate the safety and efficacy of single or multiple doses of LT3001 drug product in subjects with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
- Trial name
- NCT05198323
- Testing
- LT3001 Drug Product
- Where
- 2 sites in United States, Taiwan
- Volunteers
- 66 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Acute Ischemic Stroke, Endovascular Thrombectomy
Evaluation of Endovascular Treatment in Acute Intracranial Distal Medium Vessel Occlusion Stroke
Rationale: Distal Medium Vessel Occlusion (MeVO) are thought to cause as many as 25% to 40% of all acute ischemic strokes (AIS).
- Trial name
- NCT06146790
- Testing
- endovascular treatment, Standard medical management
- Where
- China
- Volunteers
- 564 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Pulmonary Embolism
Evaluation of the Safety and Performance of Magneto PE Kit
This study is designed as a prospective, multi-center, multinational open labeled, single armed study to evaluate the safety and performance of the Magneto PE Kit.
- Trial name
- NCT04949048
- Testing
- Magneto PE Kit
- Where
- 5 sites in Denmark, Israel and 1 more
- Volunteers
- 15 people
- Sponsor
- Magneto Thrombectomy Solutions
Stroke, Acute Ischemic
Endovascular Treatment for eXtra-Large Ischemic Stroke
The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute…
- Trial name
- XL STROKE-2 (NCT06388148)
- Testing
- Medical management, Endovascular thrombectomy
- Where
- 2 sites in China
- Volunteers
- 286 people
- Sponsor
- Zhongming Qiu
Acute Ischemic Stroke, Large Vessel Occlusion
Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as a standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Neutrophil Extracellular Trap Formation
- Trial name
- NCT07552610
- Testing
- Sivelestat sodium, Endovascular Thrombectomy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute, Vessels; Occlusion
Blood Pressure Management in Stroke Following Endovascular Treatment
The aim of DETECT is to prove the feasibility of a multicenter phase III trial testing the hypothesis that intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient…
- Conditions
- Stroke, Acute, Vessels; Occlusion, Blood Pressure, Endovascular Thrombectomy
- Trial name
- DETECT (NCT04484350)
- Testing
- Labetalol, Hydralazine, Enalapril
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Stroke Thrombectomy
Mode of Sedation During Endovascular Treatment of Vertebrobasilar Stroke
Optimal anesthetic mode is not established for patients with vertebrobasilar stroke undergoing endovascular treatment. We want to investigate whether a procedural sedation mode approach is feasible compared to general anesthesia
- Trial name
- MOONRISE (NCT05525325)
- Testing
- General Anesthesia
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- University Hospital Heidelberg