Clinical trials: Endothelial Function
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Sickle Cell Anemia
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to…
- Trial name
- NCT00937144
- Testing
- Viagra (Sildenafil)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Obese, Endothelial Function
Arginase Inhibition in Humans With Obesity
To evaluate the efficacy of arginase inhibition on endothelial function in humans with obesity.
- Trial name
- NCT05536934
- Testing
- Nω-hydroxy-nor-arginine
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska Institutet
Coronary Artery Disease
Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in CAD
The main purposes of this study is to analyze, in a randomized controlled trial, the effects of an exercise-based cardiac rehabilitation program (i) on biomarkers of endothelial function, (ii) on biomarkers of inflammation, (iii)…
- Trial name
- NCT01432639
- Testing
- Exercise-based cardiac rehabilitation program
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Universidade do Porto
Congenital Disorders
Spironolactone in Patients With Single Ventricle Heart
Ultrasound is a technique that can provide images of the blood vessels such as arteries. The size of the arteries, such as the main blood vessel in the arm, can change under different conditions.
- Trial name
- NCT00211081
- Testing
- Spironolactone (drug)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Cardiovascular Disease
Acute Heart Health Benefits of Whole Grain Barley and Oats in Healthy Men and Women
The objectives of this study are the following: 1) to determine the acute effect of whole grain barley on risk factors of cardiovascular disease compared to a diet low in whole grain, and 2) to compare the effects of whole grain…
- Trial name
- NCT01283672
- Testing
- Controlled diet with whole grain barley, whole grain oats, or low grain diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Cardiovascular
The Role of EDHFs on Blood Pressure Following a Bout of Prolonged Sitting
Canadians spend most of their day in sedentary postures (i.e., sitting, lying, reclining). While the beneficial impacts of physical activity on the heart are well-established, less is known about the consequences during time…
- Trial name
- NCT07396857
- Testing
- Fluconazole 150 mg
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Type 1 Diabetes
EFFECT OF HYBRID CLOSED-LOOP SYSTEMS ON CARDIOVASCULAR MARKERS IN TYPE 1 DIABETES.
This is a prospective, non-randomized, observational cohort study conducted in adult patients with type 1 diabetes.Participants with poorly controlled T1D under multiple daily injection (MDI) treatment will be assigned to one of…
- Trial name
- NCT07241702
- Testing
- HCLS, SGLT2 inhibitor, MDI
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Hyperlipidemia
Endothelial Hyperpolarization in Humans
The purpose of this study is to elucidate the role Endothelium-Derived Hyperpolarizing Factor (EDHF) plays in dilating blood vessels and whether it differs between healthy people and those with high cholesterol.
- Trial name
- NCT00166166
- Testing
- Tetraethylammonium (TEA), L-NG-monomethyl Arginine (L-NMMA), Bradykinin
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Emory University
Cardiovascular Diseases
Anticoagulation, Vitamins, and Endothelial Function
Determine whether low or high dose B vitamin therapy will lower homocysteine and thrombomodulin in patients anticoagulated with warfarin.
- Trial name
- NCT00018460
- Testing
- Vitamin B
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Primary Aldosteronism
The Effect of SAAE on Vascular Endothelial Function in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
- Trial name
- NCT05561361
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Heart Failure, Heart Failure With Reduced Ejection Fraction
Pilot Study Lp299v Supplementation in Chronic Heart Failure
The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05752760
- Testing
- Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical College of Wisconsin
Type 2 Diabetes Mellitus, Peripheral Microvascular Symptoms
The Effect of Prostaglandin I2 on the Endothelial Cell Function Disorder in Type 2 Diabetes Mellitus Patients
This study attempts to examine the effect of oral prostaglandin I2 (Beraprost Na), administered for eight weeks, on the endothelial cell functional disorder among asymptomatic high risk diabetes mellitus patients.
- Trial name
- NCT01061060
- Testing
- Prostaglandin I2
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Yonsei University
SDF-1 is an Important Cytokine for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors
Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM).
SDF-1, an important cytokine for neovascularisation is cleaved by (dipeptidyl peptidase IV) DPPIV. The aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin (Galvus®) on endothelial…
- Trial name
- FINNjA-DM (NCT00936234)
- Testing
- Vildagliptin
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Atherosclerosis, Coronary
Study of Intracoronary CD34+ Cell Administration in Patients With Early Coronary Atherosclerosis
How safe and effective are CD34+ cell intracoronary injections for treating coronary endothelial dysfunction (CED)?
- Trial name
- NCT03471611
- Testing
- Autologous CD34+ Cells, Granulocyte Colony-Stimulating Factor (G-CSF)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Evaluation of CTCA in Assessing Plaque Pathology and Physiology
Computed tomographic coronary angiography (CTCA) has been recently introduced to non-invasively evaluate coronary artery pathology.
- Trial name
- NCT03556644
- Testing
- CTCA imaging
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Type 2 Diabetes, Chronic Kidney Disease
Effect Of Paricalcitol (Zemplar) On Endothelial Function And Inflammation In Type 2 Diabetes And Chronic Kidney Disease
The purpose of this research study is to study the effects of paricalcitol on endothelial function and inflammation, cardiovascular risk factors which are associated with patient populations that have Type 2 diabetes and Stage 3…
- Trial name
- NCT01792206
- Testing
- Zemplar
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Scott and White Hospital & Clinic
Coronary Disease, Hypolipoproteinemia
Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)
The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on lipid profile…
- Trial name
- NCT00298909
- Testing
- physical exercise, niaspan (extended-release niacin), niacin
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Leipzig
Endothelial Dysfunction, Vascular Stiffness
Sodium Lowering Vascular Effects Trial
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension.
- Conditions
- Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction
- Trial name
- SOLVE (NCT05388032)
- Testing
- Sodium Reduction Intervention
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Tulane University
Living Kidney Donation
Vascular Remodeling After Living Kidney Donation Study
Vascular evaluation of candidates to living kidney donation is important because there is an increased risk of end stage renal disease and cardiovascular disease after donation.
- Trial name
- EUGENIA (NCT05073913)
- Testing
- Vascular remodeling characterization
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris