Clinical trials: Endoscopic Sinus Surgery
Endoscopic Frontal Sinus Surgery, Chronic Rhinosinusitis With Nasal Polyps
Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyps
The aim of this study is to evaluate the effect of the primary endoscopic frontal sinus surgery on the clinical outcome in patients having moderate to severe eosinophilic chronic rhinosinusitis with polyps with primary outcome…
- Conditions
- Endoscopic Frontal Sinus Surgery, Chronic Rhinosinusitis With Nasal Polyps, Draf III, Draf I or IIa
- Trial name
- NCT05979662
- Testing
- Endoscopic frontal sinus surgery grade 6(Draf III)., Endoscopic frontal sinus surgery grade 1-3(Draf I or IIa)
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Ibrahim Talal Elshamy
Chronic Rhinosinusitis (CRS)
Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) is commonly performed in patients with chronic rhinosinusitis (CRS) to improve sinus drainage and allow better delivery of topical therapies after surgery.
- Trial name
- PVP-I (NCT07383402)
- Testing
- Povidone-Iodine and Budesonide Gel-Forming Suspension
- Volunteers
- 180 people
- Sponsor
- Amin Javer
Hypotension Drug-Induced, Cerebral Oxygen Saturation
Effect of Controlled Hypotension on Cerebral Oxygen Saturation
For a successful functional endoscopic sinus surgery (FESS), it is crucial to provide effective controlled hypotension to reduce blood loss and provide a relatively blood-free surgical environment to facilitate surgery.
- Trial name
- NCT02967029
- Testing
- Esmolol Hydrochloride, Remifentanil Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS)
Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
This proposed study will assess the hemodynamic effects and measure the systemic absorption of topically applied oxymetazoline in patients undergoing functional endoscopic sinus surgery, turbinate surgery, or adenoidectomy.
- Conditions
- Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS), Turbinate Surgery
- Trial name
- NCT02453841
- Testing
- Oxymetazoline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Richard Cartabuke
Chronic Rhinosinusitis With Nasal Polyps
Efficacy of Long-Term Low Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps After Endoscopic Sinus Surgery
This randomized controlled trial evaluated the effectiveness of long-term, low-dose clarithromycin (250 mg/day) in reducing symptoms, improving endoscopic and radiologic scores, and preventing early recurrence of nasal polyps…
- Trial name
- NCT07316959
- Testing
- clarithromycin 250 mg
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Jinnah Medical University
Pain Management, Dexmedetomidine
Dexmedetomidine Different Doses as Adjuvant to Entropy-assisted General Anesthesia During Functional Endoscopy Sinus Surgery.
The aim of work to assess the effect of different doses of Dexmedetomidine when used as an adjuvant to entropy-guided general anesthesia on the intraoperative surgical field quality, inhaled anesthesia consumption and…
- Conditions
- Pain Management, Dexmedetomidine, Anesthesia
- Trial name
- NCT05226325
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Cairo University
Surgical Hemostasis
Comparative Study Between the Effect of Dexmedetomidine ,Midazolam or Bupivacaine Packing During FESS on Surgical Field Visualization
The goal of this interventional study is to compare the nasal packing with dexmedetomidine .midazolam or bupivacaine on surgical field visualization during FESS .
- Trial name
- FESS (Function (NCT07013955)
- Testing
- Saline, Dexmedetomidine, Midazolam
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Minia University
Endoscopic Sinus Surgery
PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Pupillary Dilatation Reflex (PRD) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using…
- Trial name
- FESSPRD (NCT03417206)
- Testing
- Remifentanil, pupillary dilatation reflex
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Chronic Rhinosinusitis (Diagnosis)
Debridement and Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is the gold standard surgical intervention for management of patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT04093193
- Testing
- Debridement
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- St. Paul's Hospital, Canada
Functional Endoscopic Sinus Surgery, Vagal Nerve Stimulation
Auricular Neuromodulation for FESS
In this blinded prospective randomized control trial the researchers will investigate the impact of cutaneous vagal nerve stimulation on surgical conditions in patients undergoing functional and ascorbic sinus surgery (FESS).
- Conditions
- Functional Endoscopic Sinus Surgery, Vagal Nerve Stimulation, Platelet Activation
- Trial name
- NCT06662422
- Testing
- Spark Biomedical Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN) System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Endoscopic Sinus Surgery
Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery
Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.
- Trial name
- NCT04078659
- Testing
- Propofol infusion, Magnesium Sulfate infusion, Lidocaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Chronic Sinus Infection
Use of Perioperative Antibiotics in Endoscopic Sinus Surgery
The objective of this study is to determine whether the use of postoperative antibiotics following endoscopic sinus surgery (ESS) decreases postoperative infection rates.
- Trial name
- NCT03369717
- Testing
- Amoxi Clavulanate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Sinusitis
Medicated Punctured-Glove-Finger Spacer Study
All adult patients undergoing sinus surgery for chronic rhinosinusitis (CRS) that satisfy the inclusion/exclusion criteria will be included in the study.
- Trial name
- FISHNET (NCT01420471)
- Testing
- Triamcinolone, Saline-impregnated spacer
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Paul's Hospital, Canada
Blood Loss
Intraoperative Bleeding During Endoscopic Sinus Surgery
The purpose of this study is to compare the blood loss during sinus surgery looking at two different types of anesthesia: either intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane.
- Trial name
- NCT01014728
- Testing
- propofol, sevoflurane
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Chronic Frontal Rhinosinusitis, Vertex to Floor Position
Effectiveness of Budesonide Nasal Instillation in a Vertex-to-floor Position
o Chronic rhinosinusitis is one of the most common health issue affected American population. Surgery plays an important role in the patients who failed the medical treatment.
- Trial name
- NCT02862509
- Testing
- Budesonide nasal instillation, Normal saline nasal instillation
- Where
- 2 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Chronic Rhinosinusitis With Nasal Polyps, Obstructive Sleep Apnea
Polysomnographic Findings in Nasal Polyposis
Nasal polyposis (NP) is a chronic inflammatory disease of the nasal and sinus mucosa leading to protrusion of edematous polyps in the nasal cavity. Prevalence of NP among the chronic rhinosinusitis patients is 25-30 %.
- Trial name
- POLYSOMNO (NCT03725956)
- Testing
- Endoscopic sinus surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Nasal Polyps, Anesthesia
Auriculotherapy for Intraoperative Blood Pressure Control
The endoscopic surgery of the paranasal sinuses (FESS) requires careful control of arterial pressure to prevent bleeding of the nasal mucosa that may lead to a reduction in the visual field.
- Conditions
- Nasal Polyps, Anesthesia, Sinusitis, ENT Surgical Result - Nose Nasal Congestion
- Trial name
- AuriFESS (NCT06182982)
- Testing
- auricolotherapy
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pain, Postoperative
Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery
The aim of the study is to quantify postoperative pain after functional endoscopic sinus surgery (FESS) and investigate whether preemptive analgesia may positively impact intraoperative anesthetic management, decrease patient…
- Trial name
- NCT00927888
- Testing
- Bupivacaine Block
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Stanford University
Sphenoid Sinus, Endoscopic Sinus Surgery
Different Endoscopic Approaches for Sphenoid Sinus
Identification of the most effective approach for different lesion types Correlation between approach and complication rates
- Trial name
- NCT07702188
- Testing
- endoscopic sinus surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University