Clinical trials: Endoscopic Mucosal Resection
Esophageal Neoplasms, Endoscopic Mucosal Resection
Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
This is a randomized, single-center clinical trial that will compare the efficacy of two substances used in the submucosal cushion formation stage of endoscopic submucosal resections of early esophageal malignant neoplasms.
- Conditions
- Esophageal Neoplasms, Endoscopic Mucosal Resection, Hyaluronic Acid
- Trial name
- NCT06077981
- Testing
- Submucous Endoscopic Dissection with hydroxyethylamide, Submucous Endoscopic Dissection with Hyaluronic acid (TS-905 Blue Eye)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Stomach Neuroendocrine Neoplasm
Safety and Efficacy of Underwater Endoscopic Mucosal Resection for Type I Gastric Neuroendocrine Tumors Measuring 5-9 mm
Study objectives: Primary objective: 1.To determine the histologic R0 resection rate of UEMR for type I gastric NETs measuring 5-9 mm. Secondary objectives: To evaluate: 1. En bloc resection rate 2.
- Trial name
- POEM (NCT07728292)
- Testing
- Endoscopic mucosal resection under water
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asian Institute of Gastroenterology, India
Endoscopic Hemostasis, Colonic Polyps
EndoClot for Preventing Rebleeding After Endoscopic Mucosal Resection (EMR)
Endoscopic mucosal resection (EMR) has been widely used as a diagnostic and treatment techniques of gastrointestinal small lesions. Postoperative rebleeding is one of the common complication following EMR.
- Trial name
- NCT01735786
- Testing
- EndoClot
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Barrett Syndrome, Barrett's Syndrome
CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia
This study focuses on demonstrating the value of probe-based Confocal Laser Endomicroscopy (pCLE) in guiding endoscopic therapeutic procedures in Barrett's Esophagus (BE).
- Conditions
- Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus
- Trial name
- CLEAN-MARGIN (NCT01032044)
- Testing
- Standard endoscopic evaluation, pCLE guided evaluation
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 164 people
- Sponsor
- Mauna Kea Technologies
Colon Cancer, Colon Polyp
Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)
The study will compare the use of cold snare, hot snare, cold EMR, and hot EMR for polyp resection. Although previous studies have compared two of the potential resection methods, no previous study has evaluated all four of the…
- Conditions
- Colon Cancer, Colon Polyp, Colon Adenoma
- Trial name
- NCT03462706
- Testing
- Cold Snare, Hot Snare, Cold EMR
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection
Endoscopic Resection of Gastrointestinal Neoplasms
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare…
- Conditions
- Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms
- Trial name
- NCT04780256
- Testing
- Endoscopic resection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Colonic Polyp, Colonoscopy
Cold Snare Endoscopic Mucosal Resection Trial
This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design.
- Conditions
- Colonic Polyp, Colonoscopy, Complication, Recurrence
- Trial name
- LPS-II (NCT03865537)
- Testing
- Cold snare EMR, Hot snare EMR, Eleview injection
- Where
- United States
- Volunteers
- 990 people
- Sponsor
- White River Junction Veterans Affairs Medical Center
Colon Polyp, Adenoma Colon
Underwater Endoscopic Mucosal Resection
The global aim of this multi-centric study is to assess the learning curve of U-EMR by an endoscopist skilled in C-EMR aiming to assess the application in real world and check the rate of complete EMR and adverse events related…
- Trial name
- NCT06073561
- Testing
- learning curve of Underwater mucosectomy
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Instituto Portugues Oncologia de Lisboa Francisco Gentil
Large Polyps in the Gastrointestinal Tract
Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection
For removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall.
- Trial name
- NCT00583466
- Testing
- Autologous blood injection, Normal saline, HPMC
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Colorectal Polyp
Cyanoacrylate to Stop Bleeding After EMR for Large Polyps
Endoscopic resection of large non-pedunculated adenomas is most often performed using the 'lift-and-cut' endoscopic mucosal resection (EMR) technique.
- Trial name
- NCT04308824
- Testing
- clipping, nebulization of glue
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Colonic Polyp
A Technique Using EBL for Removal of Pedunculated Colon Polyps
Bleeding is the most common complication associated with polypectomy of large pedunculated colonic polyp. Although several techniques have been developed to minimize bleeding, none of these methods has become the gold standard.
- Trial name
- NCT04123080
- Testing
- Endoscopic band ligation assisted polypectomy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uijeongbu St. Mary Hospital
Neoplasms, Gastric Cancer
Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia
The investigators seek to compare two techniques of removing pre-cancerous lesions from the colon. The investigators also will compare two solutions used during the procedure to determine if either solution allows for an improved…
- Trial name
- NCT01471756
- Testing
- Standard of Care Procedure as described in ARM
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Mayo Clinic
Post-endoscopic Mucosal Resection of Colon Polyps
Assessing a Endoscopic Mucosal Resection Site Using Different Endoscopic Imaging Methods
The purpose of this study is to compare the accuracy of using different endoscopic imaging technique (white light, white light with near focus, narrow band imaging (NBI), NBI with near focus) for detection of residual neoplastic…
- Trial name
- NCT02668198
- Testing
- Olympus CF190 Colonoscope High definition white light, Olympus CF190 Colonoscope White light with near focus, Olympus CF190 Colonoscope Narrow band imaging
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Michael Wallace
Neoplasms, Colorectal
Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Lesions.
EMR and ESD are both effective and safe and are associated with a very low risk of procedure related mortality when performed for colorectal laterally spreading lesions (LSL).
- Trial name
- intERsection (NCT04593407)
- Testing
- Endoscopic mucosal resection (EMR), Endoscopic submucosal dissection (ESD)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- José Carlos Marín Gabriel
Polyp Colorectal, Endoscopic Mucosal Resection
Structured TXI-RDI Integration for Endoscopic Resection
The goal of this clinical research study is to learn whether two advanced imaging tools, called Texture and Color Enhancement Imaging (TXI) and Red Dichromatic Imaging (RDI), can make the removal of large colon polyps safer…
- Trial name
- STRIkER (NCT07474844)
- Testing
- Texture and Color Enhancement Imaging (TXI) and Red Dichromatic Imaging (RDI), High Definition White Light Endosocopy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Polyp, Colorectal
Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project
Colorectal cancer is the second most common cancer in Canada. Colonoscopy and removal of precancerous polyps (polypectomy) reduces the incidence and mortality associated with colorectal cancer.
- Trial name
- NCT04559880
- Testing
- Tranexamic Acid Injection [Cyklokapron]
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Lawrence Charles Hookey
Endoscopic Resection, Clip
Clip Closure of Mucosal Defects After Endoscopic Mucosal Resection.
An simple-blind, randomized study, to evaluate the efficacy and safety of complete closure with clips of mucosal defects after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal lesions (≥ 2 cm) as…
- Conditions
- Endoscopic Resection, Clip, Haemorrhage, Non-pedunculated Lesions
- Trial name
- NCT02765022
- Testing
- Clip closure, No clip closure
- Where
- Spain
- Volunteers
- 235 people
- Sponsor
- Fundacion Miguel Servet
Adenoma Colon, Serrated Polyp
Cold EMR Vs Standard EMR for the Treatment of Large Nonpedunculated Homogeneous Colorectal Lesions
This study compares the effectiveness in complete resection (absence of recurrence at 6 months) the two different techniques for performing endoscopic mucosal resection (EMR) of nonpedunculated homogeneous colorectal lesions >20mm
- Conditions
- Adenoma Colon, Serrated Polyp, Serrated Adenoma, Colorectal Neoplasms
- Trial name
- NCT04418843
- Testing
- Standard Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Spain
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Oscar Nogales
Endoscopic Mucosal Resection
EMR-C VS EMR-S in Colonic Lateral Spreading Tumors Treatment (LST)
"Lateral Spreading Tumors" (LSTs) are dysplastic lesions whose protrusion within the lumens the colon is not more than twice as compared to the surrounding non-dysplastic mucosa.
- Trial name
- LST (NCT03498664)
- Testing
- cap for mucosectomy, standard snare for polypectomy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Endoscopic Hemostasis, Colonic Polyps
EndoClot for Hemostasis and Preventing Post-procedure Bleeding After Endoscopic Mucosal Resection
Endoscopic mucosal resection (EMR) has been widely used as a diagnostic and treatment techniques of gastrointestinal small lesions. Para-procedure bleeding is one of the common complication following EMR.
- Trial name
- EMR (NCT01496781)
- Testing
- Hemoclip, EndoClot
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xijing Hospital of Digestive Diseases