Clinical trials: Endometriosis
Endometrioma
Hemostatic Measures During Laparoscopic Cystectomy for Endometrioma
laparoscopic excision of ovarian endometriotic cysts is generally recommended because it has been associated with a higher spontaneous conception rate, residual ovarian function after the procedure may be affected
- Trial name
- NCT06421857
- Testing
- suturing, bipolar electrocoagulation
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ain Shams Maternity Hospital
Endometriosis, Endometriosis Ovary
Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis
Background: Endometriosis is a chronic gynecological disease with the growth of endometrial tissue outside the endometrium. In all its properties, this tissue is similar to the mucous membrane of the uterus.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Externa, Endometriosis, Rectum
- Trial name
- ELTA (NCT03481842)
- Testing
- Linifanib, BIBW2992, Axitinib
- Where
- Switzerland
- Sponsor
- BioGene Pharmaceutical Ltd.
Pelvic Pain Associated With Endometriosis or Adenomyosis, Pelvic Pain Associated With Refractory Endometriosis
Efficacy and Tolerability of TENS in Endometriosis-related Pain
ELECTRE is a single-center, randomized, prospective, longitudinal, controlled, two-arm, single-blind study lasting 4 weeks (P1 investigation phase) after a 4-week run-in period.
- Conditions
- Pelvic Pain Associated With Endometriosis or Adenomyosis, Pelvic Pain Associated With Refractory Endometriosis, Endometriosis
- Trial name
- ELECTRE (NCT07393295)
- Testing
- Conventional TENS, Microstimulation TENS
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Monath Electronic
Endometriosis, Endometriosis; Bowel
Intraoperative Intraabdominal Ultrasound for Endometriosis
The diagnosis of bowel endometriosis lesions is in most cases a combination of anamnesis, clinical exam, transvaginal ultrasound (and/or MRI and/or endorectal sonography) and laparoscopy.
- Conditions
- Endometriosis, Endometriosis; Bowel, Ultrasound Therapy; Complications
- Trial name
- NCT05812937
- Testing
- Intraabdominal ultrasound
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University of Palermo
Endometriosis
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on…
- Trial name
- NCT07090096
- Testing
- A whole food plant based diet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Endometriosis, Microbiome Dysbiosis
Trial Evaluating Nutritional Fiber in Digestive Symptoms of Endometriosis
This study is a double-blind, randomized, placebo-controlled study that evaluates the safety and tolerability of a fiber-based dietary supplement and the mechanistic and structure-function effects of that supplement on the gut…
- Conditions
- Endometriosis, Microbiome Dysbiosis, Gastrointestinal Symptoms
- Trial name
- TEND (NCT07875062)
- Testing
- Fiber
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Endometriosis
Effect of FODMAP Diet on Pain, Quality of Life, and Sexual Function in Women With Pelvic Endometriosis and Gastrointestinal Symptoms
The main objective of the study is to assess whether a dietary regimen based on the principles of the FODMAP diet, compared with the current treatment programme which does not include specific dietary recommendations, can improve…
- Trial name
- FODMAPendo (NCT07590895)
- Testing
- FODMAP diet
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Endometriosis
Superficial and Deep Endometriosis: Role of Systemic Inflammation as a Marker of Clinical, Surgical, and Reproductive Outcomes
Primary aim of this study is to evaluate the change in systemic inflammation parameters after surgery for superficial, ovarian or deep endometriosis.
- Trial name
- ESPRIMO-CCR (NCT06470594)
- Where
- Italy
- Volunteers
- 138 people
- Sponsor
- University of Campania Luigi Vanvitelli
Bowel Endometriosis
Conservative Treatment of Rectosigmoid Endometriosis Monitored by Transvaginal Ultrasound
Background: Endometriosis is a disease affecting 8-15 % of fertile women and is a cause of abdominal pain and suffering during women's menstrual periods.
- Trial name
- NCT02100345
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- University of Aarhus
Endometriosis
Barbed Sutures Versus Conventional Sutures in Laparoscopic Excision of Endometrioma
The aim of this randomized controlled trial is to compare operative data and early postoperative outcomes of laparoscopic excision of endometrioma using barbed sutures with those of laparoscopic excision of endometrioma using…
- Trial name
- NCT02308995
- Testing
- Cystectomy using barbed sutures, Cystectomy using conventional sutures, V-Loc (Covidien, Mansfield, MA)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Aljazeera Hospital
Ovarian Reserve, Endometrioma, PTEN-AKT-FOXO3 Gene Expression
PTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in Endometriomas
In this study, we aimed to investigate the relationship between PTEN-AKT-FOXO3 gene expression and decrease in ovarian reserve in the presence of endometrioma and other benign ovarian pathologies.
- Trial name
- NCT04058912
- Testing
- PTEN-AKT-FOXO3 Gene Expression
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uludag University
Menorrhagia, Dysfunctional Uterine Bleeding
Study of Conventional Laparoscopic Hysterectomy Versus Robot-Assisted Laparoscopic Hysterectomy at a Teaching Institution
Approximately 600,000 women undergo hysterectomy each year in the United States, of which 12% are laparoscopic. The most common indications for hysterectomy are: symptomatic uterine leiomyomas (40.7%), endometriosis (17.7%), and…
- Conditions
- Menorrhagia, Dysfunctional Uterine Bleeding, Leiomyoma, Pelvic Pain
- Trial name
- NCT01581905
- Testing
- Conventional Laparoscopic Hysterectomy (LH), Robot Assisted Hysterectomy
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dysmenorrhea, Endometriosis
Effect of Melatonin on Reduction of Pelvic Pain
In two double blinded randomized controlled trials (RCT) we will study the effect of pain reduction of melatonin vs placebo in women with severe dysmenorrhea and women with endometriosis.The aim is to find an effective method for…
- Trial name
- NCT03782740
- Testing
- Melatonin 10 mg, Melatonin 20 mg
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Endometriosis, Rectum, Endometriosis of Vagina
Rectal Water-contrast Transvaginal Ultrasonography Versus Sonovaginography for the Diagnosis of Posterior Deep Pelvic Endometriosis
As the surgical treatment of posterior deep endometriosis may be challenging for surgeons and carry significant risks for patients, preoperative assessment of the location, characteristics and presence of nodules of posterior…
- Conditions
- Endometriosis, Rectum, Endometriosis of Vagina, Endometriosis Rectovaginal Septum, Endometriosis Pelvic
- Trial name
- NCT04296760
- Testing
- Rectal water-contrast transvaginal ultrasonography, Sonovaginography
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fabio Barra
Endometriosis
Endometrioma Related Reduced Ovarian Reserve
Prior studies have shown surgical excision of endometriomas are associated with a decline in ovarian reserve as assessed by serum anti-Mullerian Hormone (AMH) levels.
- Trial name
- ERROR (NCT02438735)
- Testing
- laparoscopic endometrioma excision, Conservative follow up
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Uludag University
Endometriosis
Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity
Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of endometriotic patients.The aim of this study…
- Trial name
- NCT04091997
- Testing
- serum Eliza assay
- Volunteers
- 300 people
- Sponsor
- Fayoum University Hospital
Endometriosis
Musculo-scrawny Manifestation Associated With the Endometriosis
The endometriosis is defined by the presence of endometriosic tissue outside of the womb and the prevalence is estimated to be 10% of women.Here is a project aimed to compare musculo-scrawny pains between patients with…
- Trial name
- NCT03305120
- Testing
- pain VAS evaluation
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Endometriosis
The Role of FAPI PET-CT in Diagnosing Endometriosis
Patients with suspected endometriosis scheduled for surgery will be identified. They will be asked to participate in a study evaluating the feasibility of FAPI PET-CT in diagnosing endometriosis.
- Trial name
- NCT06792318
- Testing
- FAPI PET-CT
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Ziv Hospital
Endometriosis, Pain
Feasibility of a Mindfulness Intervention for Endometriosis Surgery
Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session…
- Conditions
- Endometriosis, Pain, Mindfulness
- Trial name
- NCT06141720
- Testing
- pain education, mindfulness of pain introduction and intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center