Clinical trials: Endometrial Sampling
Endometrial Biopsy
COL-1077 (Lidocaine Bioadhesive Gel, 10%) in Women Undergoing Transvaginal Pipelle-Directed Endometrial Biopsy
The purpose of this study is to determine if COL-1077 (10% lidocaine vaginal bioadhesive gel) will be effective as an acute-use anesthetic and can decrease the pain intensity associated with gynecologic procedures using…
- Trial name
- NCT02465320
- Testing
- COL-1077
- Where
- 23 sites in United States
- Volunteers
- 187 people
- Sponsor
- Juniper Pharmaceuticals, Inc.
Endometriosis, Endometrioma
Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
- Trial name
- NCT06847685
- Where
- 3 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Infertility, Clinical Pregnancy Rate
Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination
Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles
- Trial name
- NCT00737984
- Testing
- Endometrial sampling
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Endometrial Diseases
Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases
The postmenopausal women with vaginal bleeding were selected in this cross-sectional study. The basic characteristics information and endometrial blood flow energy index of endometrium were detected by color power Doppler…
- Trial name
- NCT03289468
- Testing
- Voluson E8 (GE Medical Systems, USA), Minimally Invasive Endometrium Sampler
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Infertility
Endometrial Sampling (Pipelle)in IVF Patients
A prospective cross-over randomized study aimed to test the hypothesis that local injury of the endometrium increases the implantation rate in the successive cycle.
- Trial name
- NCT00411021
- Testing
- Pipelle (Endometrial Sampling)
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Menorrhagia, Endometrial Biopsy
Vaginal Misoprostol for Cervical Ripening Prior to Endometrial Biopsy
The purpose of this study is to determine whether using Misoprostol vaginally before an office endometrial biopsy is performed, will make it easier, more successful and less painful to do the procedure.
- Conditions
- Menorrhagia, Endometrial Biopsy, Cervical Ripening
- Trial name
- NCT00953641
- Testing
- Misoprostol
- Where
- Canada
- Sponsor
- University of Saskatchewan
Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Efficacy of Diclofenac on Pain During Endometrial Sampling
Abnormal uterine bleeding is common in Thai women. Traditionally, because of a larger number of patients, the diagnosis of its cause is performed via fractional curettage under local anesthesia such as paracervical nerve block or…
- Trial name
- NCT01762306
- Testing
- Diclofenac Potassium, Folic Acid
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Mahidol University
Pain
Effect of Lidocaine Spray for Pain Relief During Endometrial Biopsy: a Randomized, Double-blind, Placebo-controlled Clinical Trial
The effect of lidocaine spray on pain relief during endometrial sampling.
- Trial name
- NCT02039661
- Testing
- Lidocaine Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kayseri Education and Research Hospital
Endometrial Hyperplasia
Comparison of Dilatation & Curettage and Endometrial Aspiration Biopsy Accuracy in Patients Treated With Progestin for Endometrial Hyperplasia: A Korean Gynecologic Oncology Group Study
A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with D\&C in patients treated with progestin for endometrial hyperplasia (EH).
- Trial name
- NCT02412072
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Korean Gynecologic Oncology Group
Postmenopause
Observational Study Analyzing RNA Expression Of Endometrial Biopsy Samples From Placebo, Bazedoxifene/Conjugated Estrogens And Raloxifene
This study is an observational study analyzing the biopsy samples collected from subjects that participated in Study 3115A1-303 (NCT00675688).
- Trial name
- NCT00847821
- Testing
- Bazedoxifene 10 mg/CE 0.625 mg, Bazedoxifene 20 mg/CE 0.625 mg, Bazedoxifene 40 mg/CE 0.625 mg
- Where
- 22 sites in United States
- Volunteers
- 185 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Ovarian Cancer, Endometrial Cancer
Advanced Methods for Cancer Detection by Vaginal Screening
This pilot study is the first step in the development of an new assay that may be further tested as a screening method for ovarian and endometrial cancers.
- Trial name
- ADVISE (NCT02622776)
- Testing
- Vaginal DNA Collection
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Anna Tinker
Abnormal Uterine Bleeding (AUB)
Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding
women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively…
- Trial name
- NCT07731581
- Testing
- Manual Vacuum Aspiration (MVA) Cannula, Pipelle Endometrial Suction Curette
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Chronic Anovulation
Hysteroscopy in Chronic Anovulation
Patients with chronic anovulation presenting to the IVF clinic for subfertility treatment are at increased risk of endometrial hyperplasia and carcinoma.They are often subjected to endometrial biopsy to rule out any underlying…
- Trial name
- NCT03545945
- Testing
- Additional office hysteroscopy, Endometrial biopsy
- Where
- United States
- Sponsor
- University of South Florida
Infertility, Pregnancy
Effect of Endometrial Biopsy on in Vitro Fertilization Pregnancy Rates - a Multicenter Study
Animal and clinical studies have suggested that local tissue trauma can promote the process of an embryo implanting in the uterine cavity.
- Trial name
- EndoBx-IVF (NCT01983423)
- Testing
- Endometrial Biopsy
- Where
- 2 sites in Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jon Havelock
Contraception
Endometrial Biopsy in Progestin Contraceptive Users
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first…
- Trial name
- NCT05760144
- Testing
- DMPA, Etonogestrel implant
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Endometrial Biopsy
Pipelle vs the Curved Aspirator Device
The primary aim of this study is to rigorously compare the efficacy of two commonly used endometrial sampling devices, the Pipelle and the Miltex, these devices are standard of care at Maimonides.
- Trial name
- NCT07513493
- Testing
- Curved Tip Aspirator, Pipelle
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Jefferson Drapkin
Histopathology, Screening Tool
Improving Outpatient Endometrial Biopsy Results
Pipelle is the most commonly used outpatient endometrial biopsy device. Pipelle endometrial biopsy can diagnose 90% of endometrial cancer cases.
- Conditions
- Histopathology, Screening Tool, Techniques
- Trial name
- NCT06694246
- Testing
- Improving technique, Using hysteroscopy in candidate patients, Analgesia
- Where
- Kuwait
- Volunteers
- 400 people
- Sponsor
- Cairo University
Endometrial Biopsy
The Effect of Virtual Reality on Anxiety and Pain During Endometrial Biopsy
The aim of this study was to reduce the anxiety and pain felt during endometrial biopsy procedure.
- Trial name
- NCT06180317
- Testing
- Virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Post-Menopausal Bleeding, Post-Menopausal Endometrial Thickness
Evaluation of a New Hysteroscopic Grasper for Endometrial Biopsy in Post-menopausal Patients
Hysteroscopic endometrial biopsy is usually performed through the classic spoon grasper. Recently, a new hysteroscopic grasper with knurled terminal end and cutting jaws was designed, in order to improve feasibility of the…
- Trial name
- NCT03427957
- Testing
- Endometrial biopsy with the new hysteroscopic grasper with knurled terminal end and cutting jaws, Endometrial biopsy with the hysteroscopic spoon grasper, Endometrial biopsy with the hysteroscopic alligator grasper
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- Università degli Studi dell'Insubria
Sterility
Embryo Implantation After Induced Endometrial Injury
Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.
- Trial name
- NCT01955356
- Testing
- Scratching
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA