Clinical trials: Endometrial Sampling
Infertility
Autologous Endometrial Coculture (AECCT)
The purpose of this study is to determine if the use of Autologous Endometrial Coculture (AECC) in young in vitro fertilization (IVF) patients with poor ovarian reserve improves pregnancy outcome.
- Trial name
- AECCT (NCT01472861)
- Testing
- AECC (Autologous endometrial coculture), no endometrial biopsy or Autologous endometrial coculture (AECC) performed
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Repeated Implantation Failures
Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles
The iatrogenic induction of local endometrial injury caused through hysteroscopy or pipelle sampling in the preceding non- transfer cycle improves the IVF outcome parameters in patients with previous IVF failures.
- Trial name
- NCT01798862
- Testing
- Endometrial injury by hysteroscopy or pipelle sampling, Proceed to COH directly
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Endometrial Cancer
Lymph Node Counts in Endometrial Cancer Staging
The purposes of this study are to determine whether total lymph node count or the percentage of identified nodes with metastatic disease are influenced by (1) the method of categorizing tissue specimens or (2) the techniques of…
- Trial name
- NCT02335775
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Infertility, Endometrium
Therapeutic Endometrial Biopsy
The aim of this study is to evaluate the potential benefits in implantation, clinical pregnancy and live birth rates by an endometrial biopsy prior to an IVF/ICSI treatment.
- Conditions
- Infertility, Endometrium, ART, Endometrial Biopsy
- Trial name
- NCT01963819
- Testing
- Endometrial biopsy
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Endometrial Flora Characterization in Infertile Women
Endometrial Flora in Women Undergoing IVF Treatments
Characterization of the female genital tract microbiome in women undergoing IVF treatment
- Trial name
- NCT03208595
- Testing
- Endometrial sampling of a Typical Embryo transfer catheter
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Anxiety, Pain
Investigating Pre-Procedural Anxiety and Effect of Analgesia on Intrauterine Device Placement and Endometrial Biopsy
The purpose of this study is to evaluate pre-procedural anxiety and patient pain perception with IUD insertion/ EMB procedure when using analgesia versus no analgesia by the end of the study and to evaluate the effect of age…
- Trial name
- NCT07031206
- Testing
- Paracervical block- Lidocaine without epinephrine, Benzocaine Gel applied to the cervix, Hydroxyzine Hydrochloride
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The University of Texas Health Science Center, Houston
Abnormal Uterine Bleeding
Studies on the H Pipelle, a New Device for Endometrial Sampling at Hysteroscopy
The investigators have developed a novel instrument for taking endometrial biopsies at no touch (vaginoscopic) hysterectomy which avoids the need to instrument the vagina with speculums and tenaculums, and also avoids the…
- Trial name
- NCT00755651
- Testing
- Endometrial biopsy
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Royal Free Hampstead NHS Trust
Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding Using Sublingual Misoprostol
Abnormal uterine bleeding is common in Thai women. Fractional curettage is an diagnostic procedure of this condition. Traditionally, fractional curettage is performed under local anesthesia such as paracervical nerve block or…
- Trial name
- NCT01762319
- Testing
- Misoprostol, Vitamin B6
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Women With Suspected or Confirmed Gynecological Disease
DOvEEgene Fleur: New Uterine Sampling Tool
This study is related to a previous study from the same group which started in 2014 (NTC02288676, McGill REB A08-M79-13B, MUHC REB 2020-5945) to develop a clinically implementable screening test -DovEEgene: developing and…
- Trial name
- NCT04258449
- Testing
- DOvEEgene Fleur Sampling
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University
Endometrial Biopsy
1% Lidocaine Paracervical Block for Endometrial Biopsy
The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention.
- Trial name
- NCT06546254
- Testing
- Lidocaine 1% Injectable Solution, Capped needle
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Endometrial Cancer, Post-Menopausal Bleeding
Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding.
TITLE Pipelle® under Ultrasound Guidance (PUG) to investigate post-menopausal bleeding: Randomised Controlled Trial BACKGROUND Women who are suspected of having endometrial cancer (cancer of the inner lining of the womb) due to…
- Conditions
- Endometrial Cancer, Post-Menopausal Bleeding, Endometrial Hyperplasia
- Trial name
- PUG (NCT06501846)
- Testing
- Pipelle® endometrial biopsy performed under transabdominal ultrasound guidance, Pipelle® endometrial biopsy performed without ultrasound guidance
- Where
- United Kingdom
- Volunteers
- 92 people
- Sponsor
- Imperial College Healthcare NHS Trust
Endometrial Neoplasms
The Feasibility Study of the Li Brush for the Screening of Endometrial Cancer in the Postmenopausal Period
Investigators aim to collect endometrial sampling with Li Brush among target population who have risks for endometrial neoplasm, then Fractional curettage should performed with these participants, investigators intend to compare…
- Trial name
- NCT02512848
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Endometrial Biopsy, Abnormal Uterine Bleeding
Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy
The purpose of this study to determine effectiveness of paracervical block, lidocaine spray and only oral analgesic drugs for pain relief during endometrial biopsy.
- Trial name
- NCT01908738
- Testing
- paracervical block with 1%lidocaine, 10%lidocaine spray
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Biopsy
Hysteroscopic Guided Endometrial Sampling: Prospective Comparison Between 5Fr and 7Fr Biopsy Forceps (HYSTEROBIO)
Indication for hysteroscopic guided biopsy compared to blind biopsy have been little evaluated. However, this kind of biopsy is usually performed in many centre.
- Trial name
- HYSTEROBIO (NCT04519554)
- Testing
- Endometrial sampling
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endometrial Cancer, Endometrial Cancer Precursors
The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer in Tampons
BACKGROUND: Endometrial cancer is a common and deadly cancer for women. It is getting more common and deadly because risk factors like age and obesity are increasing.
- Conditions
- Endometrial Cancer, Endometrial Cancer Precursors, Ovarian Cancer, Complex Atypical Endometrial Hyperplasia
- Trial name
- DETECT (NCT03538665)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Endometrial Adenocarcinoma, Stage I Uterine Corpus Cancer
Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus
This randomized phase III trial is studying laparoscopic surgery to see how well it works compared to standard surgery in treating patients with endometrial cancer or cancer of the uterus.
- Conditions
- Endometrial Adenocarcinoma, Stage I Uterine Corpus Cancer, Stage I Uterine Sarcoma, Stage II Uterine Corpus Cancer
- Trial name
- NCT00002706
- Testing
- Laparoscopic Surgery, Quality-of-Life Assessment, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 2,616 people
- Sponsor
- Gynecologic Oncology Group
Cancer Screening
Endometrial Cancer Screening in High-risk Populations
Endometrial cancer is one of the most common malignancies of the reproductive system. The incidence of endometrial cancer has increased in recent years. No effective, low-cost screening method for populations at high risk exists.
- Trial name
- NCT06125886
- Testing
- transvaginal ultrasound and microscale endometrial sampling biopsy
- Volunteers
- 22,000 people
- Sponsor
- Peking University People's Hospital
Office Hysteroscopy and Endometrial Biopsy
Misoprostol in Office Hysteroscopy and Endometrial Biopsy
We hypothesize that use of vaginal misoprostol will help in reducing the pain scores when used prior to concurrent office hysteroscopy and endometrial biopsy in a particular subgroup of women who are anticipated to require…
- Trial name
- NCT03547778
- Testing
- Misoprostol 50 mcg pesssary
- Where
- United States
- Sponsor
- University of South Florida
Endometrial Biopsy, Intrauterine Devices
Methoxyflurane for IUD Insertion and Endometrial Biopsy
The aim of this study is to determine if 3ml of inhaled Methoxyflurane, in the form of a Penthrox inhaler, reduces pain during IUD insertion and/or endometrial biopsy. The proposed study is a double-blind, placebo-controlled RCT.
- Trial name
- NCT07046572
- Testing
- Methoxyflurane - Penthrox
- Where
- Canada
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Endometrial Cancer
MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging.
- Trial name
- NCT06677112
- Testing
- Selective surgical staging, REFLEX
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Rachel Miller