Clinical trials: Endodontics
Endodontic Disease
Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles
Successful endodontic treatment depends primarily on the elimination of infecting microorganisms. This is done by chemo-mechanical preparation of root canals, which is not enough and microorganisms might still survive.
- Trial name
- NCT04481945
- Testing
- bioceramic sealer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
Endodontics, Regenerative Endodontic Procedures
The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
- Conditions
- Endodontics, Regenerative Endodontic Procedures, PRF, i-PRF
- Trial name
- NCT07721051
- Volunteers
- 60 people
- Sponsor
- Kırıkkale University
Nonvital Tooth
Clinical & Radiographic Evaluation of Neo MTA Versus White MTA in Revascularization of Non-Vital Immature Permanent Teeth
To evaluate and compare the degree of tooth discoloration in tooth crowns induced by Neo MTA versus white MTA over time. Evaluation of the effectiveness of Neo MTA as coronal plug in revascularization of immature teeth with…
- Trial name
- NCT03545139
- Testing
- NeoMTA nusmile, White MTA
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cryotherapy Effect, Irreversible Pulpitis
Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children
The aim of the study is to assess the efficacy of cryotherapy application on the success of inferior alveolar nerve block (IANB) in reducing pain during pulp therapy of the mandibular first permanent molars with irreversible…
- Conditions
- Cryotherapy Effect, Irreversible Pulpitis, Pain
- Trial name
- NCT05441995
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Minia University
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Teeth, Endodontically-Treated
Safety and Efficacy of Using the Endodontic Self Adjusting File - SAF for Root Canal Treatment
The study's primary goal is to assess the safety of the SAF (Self Adjusting File) device for root canal treatments. The study's secondary goal is to evaluate the effectiveness of the SAF device for root canal treatments
- Trial name
- NCT00497042
- Testing
- Self Adjusting File
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ReDent Nova
Apexification, Root Canal Therapy
Antimicrobial Pastes and Clinical Cases of Apexogenesis
The aim of this study was to perform a clinical and microbiological evaluation of teeth with incomplete apexogenesis and traumatic necrosis that were treated with a revascularization technique, evaluating the microbial reduction…
- Conditions
- Apexification, Root Canal Therapy, Dental Trauma
- Trial name
- NCT03112291
- Testing
- Apexification
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Adriana Kelly de Sousa Santiago Barbosa
Apical Periodontitis
Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontitis
Background Root canal therapy is the primary treatment of choice for necrotic mature teeth with periapical lesions (PRLs), which does not restore the tooth's vitality.
- Trial name
- NCT06179433
- Testing
- Root canal treatment, Regenerative endodontic procedure
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Treatment, Apical Periodontitis
The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature.
Each year, nearly 200,000 teeth undergo root canal treatment in Sweden, most of them within general dental care. However, studies that evaluate the outcomes of root canal treatments have almost exclusively been conducted at…
- Conditions
- Endodontic Treatment, Apical Periodontitis, Quality
- Trial name
- NCT07244250
- Volunteers
- 1,500 people
- Sponsor
- Region Jönköping County
Periapical Diseases
Efficiency of Diode Laser in Control of Post-endodontic Pain
Study is a Randomized clinical trial conducted at Endodontic department- Ain Shams university Cairo. Egypt. 180 eligible patients were selected and included in the study to assess the post-endodontic pain of diode laser activated…
- Trial name
- NCT04315259
- Testing
- Diode laser
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Effectiveness of Microscope During Apical Surgery in Endodontic Treated Teeth.
RCT: Effectiveness of a Microscope During Dental Root Apical Surgery
An endodontic treatment is the standard therapy for teeth with periapical periodontitis. The overall success rate for this treatment is high; 97% of the treated teeth are retained in the oral cavity after 8 years (Salehrabi \&…
- Trial name
- NCT01759069
- Testing
- Surgical treatment with microscope
- Where
- Netherlands
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pulp and Periapical Tissue Disease
Regenerative Endodontics for Non-vital Primary Molars
Non-vital primary molars will be treated with regenerative endodontic idea using different capping materials aiming to replace the necrotic pulp tissue with biological one and to provide perfect seal over the scaffold
- Trial name
- NCT05098483
- Testing
- Regeneration in primary molars by using MTA, Regeneration in primary molars by using biodentine, Conventional Root canal treatment in primary molars
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endodontic Disease, Pulp Disease, Dental
Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication
The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.
- Trial name
- NCT06196515
- Testing
- Calcium hydroxide, nano calcium hydroxide
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Root Canal Treatment
Retrospective Database Study: Influence of Post-endodontic Restoration Placement on Survival of Root Canal-treated Teeth
The aim of this study is to assess the influence (i.e. type and timing) of post-endodontic restorations on the survival of root canal-treated teeth and to determine the influence of patient-, tooth-, treatment-, and…
- Trial name
- NCT06441058
- Testing
- No patient treatment is associated with the study
- Where
- Germany
- Volunteers
- 541 people
- Sponsor
- University of Göttingen
Chronic Apical Periodontitis
Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth
The goal of this clinical trial is to learn whether regenerative endodontic treatment (RET) should be performed in one visit or two visits in people with mature permanent teeth with chronic apical periodontitis.
- Trial name
- NCT07480226
- Testing
- Single-Visit Regenerative Endodontic Treatment, Multiple-Visit Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Marmara University
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Post Operative Pain
Postoperative Pain After the Use of Different Last Irrigation Method During Root Canal Treatment in Primary Teeth
This study was to evaluate and compare the postoperative pain levels after using EndoActivator and conventional endodontic syringe irrigation in root canal therapy of primary molars.
- Trial name
- NCT04197531
- Testing
- Irrigation Method
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Regenerative Endodontics
Clinical and Radiographic Outcomes of PRF, Chitosan, and Blood Clot in Regenerative Endodontics of Molars
This clinical trial aimed to evaluate the long-term effects of using chitosan, blood clots, and platelet-rich fibrin as scaffolds in regenerative endodontics on tooth development.
- Trial name
- NCT07119619
- Testing
- Regenerative Endodontic Treatment Using a Blood Clot as a Scaffold, Regenerative Endodontic Treatment Using a Chitosan as a Scaffold, Regenerative Endodontic Treatment Using a Platelet Rich Fibrin as a Scaffold
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pulpal Inflammation
Assessment of Pain Using Two Different Irrigation Systems After Root Canal Treatment
assessment of pain using two different irrigation systems after root canal treatment
- Trial name
- NCT07108842
- Testing
- Conventional Needle Irrigation, Conventional Needle Irrigation (Control Group), endoactivator
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- HITEC-Institute of Medical Sciences
Irreversible Pulpitis
Evaluation of Bacterial Reduction After Pulpectomy in Primary Molars
The primary aim of the study is to compare the bacterial reduction in pulpectomy of primary molars using a single rotary file system versus conventional manual instrumentation.
- Trial name
- NCT07472751
- Testing
- Rotary Instrumentation, Manual Instrumentation
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University